Changes of ghrelin following oral glucose tolerance test in obese children with insulin resistance

Wang, Xiumin; Jiang, Yinlai; Liang, Li; Du, Lizhong

doi:10.3748/wjg.14.1919

Cited by 16 publications

(4 citation statements)

References 31 publications

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“…In a study it was reported that ghrelin levels decreased with the advancing pubertal stage in obese children with insulin resistance. This study also showed that suppression of ghrelin secretion following oral glucose tolerance test was influenced by the pubertal stage (23). Another study demonstrated the ghrelin levels inversely correlated with luteinizing hormone and testosterone levels (24).…”

Section: Ghrelinsupporting

confidence: 54%

Hormones and cytokines in childhood obesity

2010

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Section: Ghrelinsupporting

confidence: 54%

Hormones and cytokines in childhood obesity

2010

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“…Human studies suggest that insulin exerts an inhibitory effect on ghrelin secretion since plasma ghrelin and insulin levels show an inverse relationship at the time of food intake and during an euglycemia clamp [29]. Another human study showed a lack of significant correlation of systemic ghrelin with insulin changes in response to an OGTT in obese children with insulin resistance [30]. Additionally, in rats with streptozotocin-induced diabetes, plasma ghrelin levels decreased following a meal in spite of a blunted rise in systemic insulin levels [31].…”

Section: Discussionmentioning

confidence: 99%

Influence of a long-term high-fat diet on ghrelin secretion and ghrelin-induced food intake in rats

Gómez

Han

Englander

et al. 2012

Regulatory Peptides

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The aims of this study were: (1) to define the extent to which a high-fat (HF) diet given on a long-term basis reduces resting plasma ghrelin (total [acyl + des-acyl]) levels and the plasma ghrelin (total) response to fasting, (2) to determine whether a chronic HF diet modifies the orexigenic activity of acyl-ghrelin, (3) whether insulin pretreatment inhibits the plasma ghrelin (total) response to fasting, and (4) the extent to which pioglitazone (PIO) treatment will increase stomach and plasma ghrelin (total) levels in rats fed a HF diet. PIO is a drug given to diabetics which improves insulin resistance. Our findings show that a chronic HF diet given for either 10 or 60 weeks exerts a persistent inhibitory effect on resting plasma ghrelin (total) levels. Additionally, the plasma ghrelin (total) elevation to overnight fasting is not altered in rats fed a HF diet on a long-term basis. A HF diet does not impair the ingestive response to acyl-ghrelin. Together, these results suggest that acyl-ghrelin serves as an important orexigenic factor. Results show that insulin pretreatment does not inhibit the plasma ghrelin (total) response to fasting suggesting that meal-induced insulin secretion does not have a role in reducing ghrelin (total) secretion. In rats fed a HF diet, PIO administration increases stomach ghrelin (total) levels. Because PIO can reduce systemic glucose and lipid levels, our findings suggest that elevated glucose and lipid levels are part of the inhibitory mechanism behind reduced ghrelin (total) secretion in rats fed a HF diet.

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“…In a number of studies, plasma levels of ghrelin in obese children were compared with those of normal weight controls. Generally, the plasma ghrelin concentration of obese children is lower in fasting condition [ 6 – 10 ], whereas the decline in response to glucose ingestion varies as a function of insulin sensitivity; the decline appears to be less profound in insulin resistant obese children [ 6 , 11 ], although the data are equivocal [ 12 ]. Weight loss tends to normalize circulating ghrelin levels [ 8 , 10 , 13 ], although this is still a subject for debate [ 5 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Multidisciplinary Lifestyle Intervention on the Pre- and Postprandial Plasma Gut Peptide Concentrations in Children with Obesity

et al. 2011

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Objective. This study aims to evaluate the effect of a multidisciplinary treatment of obesity on plasma concentrations of several gut hormones in fasting condition and in response to a mixed meal in children. Methods. Complete data were available from 36 obese children (age 13.3 ± 2.0 yr). At baseline and after the 3-month multidisciplinary treatment, fasting and postprandial blood samples were taken for glucose, insulin, ghrelin, peptide YY (PYY), and glucagon-like peptide 1 (GLP-1). Results. BMI-SDS was significantly reduced by multidisciplinary treatment (from 4.2 ± 0.7 to 4.0 ± 0.9, P < .01). The intervention significantly increased the area under the curve (AUC) of ghrelin (from 92.3 ± 18.3 to 97.9 ± 18.2 pg/L, P < .01), but no significant changes were found for PYY or GLP-1 concentrations (in fasting or postprandial condition). The insulin resistance index (HOMA-IR) remained unchanged as well. Conclusion. Intensive multidisciplinary treatment induced moderate weight loss and increased ghrelin secretion, but serum PYY and GLP-1 concentrations and insulin sensitivity remained unchanged.

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Changes of ghrelin following oral glucose tolerance test in obese children with insulin resistance

Cited by 16 publications

References 31 publications

Hormones and cytokines in childhood obesity

Hormones and cytokines in childhood obesity

Influence of a long-term high-fat diet on ghrelin secretion and ghrelin-induced food intake in rats

The Effect of Multidisciplinary Lifestyle Intervention on the Pre- and Postprandial Plasma Gut Peptide Concentrations in Children with Obesity

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