2013
DOI: 10.4238/2013.november.26.4
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Changes of gene expression profiles across different phases of vascular calcification in rats

Abstract: ABSTRACT. This study investigated the alteration of gene expression profiles in order to gain a deeper understanding into the molecular mechanism involved in different processes of vascular calcification (VC). Sprague Dawley (SD) rats were injected with 300,000 μg/kg vitamin D 3 and gavaged with 25 mg/kg nicotine for 8 or 16 weeks to create 8-and 16-week VC calcification groups. Histological analysis and quantification of aortic calcium content were used to determine the severity of vascular calcification. The… Show more

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Cited by 7 publications
(1 citation statement)
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“…However, VC is an active process which the mechanisms of bone formation, inhibitors of mineralization and local alterations of the vessel wall take part in [1]. One pivotal point of VC is probably the vascular smooth muscle cell (VSMC) with its phenotype changes ending in vessel mineralization [2]. The phenotype shift of VSMC seems to be induced by a variety of conditions such as inflammation [3], reactive oxygen species (ROS) [4,5] and senescence [6].…”
Section: Introductionmentioning
confidence: 99%
“…However, VC is an active process which the mechanisms of bone formation, inhibitors of mineralization and local alterations of the vessel wall take part in [1]. One pivotal point of VC is probably the vascular smooth muscle cell (VSMC) with its phenotype changes ending in vessel mineralization [2]. The phenotype shift of VSMC seems to be induced by a variety of conditions such as inflammation [3], reactive oxygen species (ROS) [4,5] and senescence [6].…”
Section: Introductionmentioning
confidence: 99%