Changes of functional connectivity of the subgenual anterior cingulate cortex and precuneus after cognitive behavioral therapy combined with fluoxetine in young depressed patients with suicide attempt

Shu, Yanping; Wu, Gang; Bi, Bin; Liu, Jiaoying; Xiong, Jie; Kuang, Li

doi:10.1016/j.bbr.2021.113612

Cited by 5 publications

(5 citation statements)

References 43 publications

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“…Besides, Shu et al . indicated the decreased FC between bilateral sgACC in young depressed patients with suicide attempts after treatment than pretreatment, indicating that the bilateral sgACC was relatively susceptible to treatment (Shu et al ., 2022 ), which is also supported by the evidence from Yoshimura (Yoshimura et al ., 2017 ). Taking all these findings together with our results, we speculate that the impaired function and reduced connections of the sgACC may be associated with a disregulate negative emotional expression and experience, and might be more sensitive in MDD than PDD.…”

Section: Discussionsupporting

confidence: 81%

Postpartum depression and major depressive disorder: the same or not? Evidence from resting-state functional MRI

et al. 2022

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Background Although postpartum depression (PPD) and non-peripartum major depressive disorder (MDD) occurring within and outside the postpartum period share many clinical characteristics, whether PPD and MDD are the same or not remains controversial. Methods The current study was devoted to identify the shared and different neural circuits between PPD and MDD by resting-state functional magnetic resonance imaging data from 77 participants (22 first-episodic drug-naïve MDD, 26 drug-naïve PPD, and 29 healthy controls (HC)). Results Both the PPD and MDD groups exhibited higher fractional amplitude of low-frequency fluctuation (fALFF) in left temporal pole relative to the HC group; the MDD group showed specifically increased degree centrality in the right cerebellum while PPD showed specifically decreased fALFF in the left supplementary motor area and posterior middle temporal gyrus (pMTG_L), and specifically decreased functional connectivities between pMTG and precuneus and between left subgeneual anterior cingulate cortex (sgACC_L) and right sgACC. Moreover, sgACC and left thalamus showed abnormal regional homogeneity of functional activities between any pair of HC, MDD, and PPD. Conclusions These results provide initial evidence that PPD and MDD have common and distinct neural circuits, which may facilitate understanding the neurophysiological basis and precision treatment for PPD.

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Section: Discussionsupporting

confidence: 81%

Postpartum depression and major depressive disorder: the same or not? Evidence from resting-state functional MRI

et al. 2022

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“…Consistently, other studies have proposed the application of ALFF as a diagnostic neuroimaging biomarker of MDD in both adolescent and adult populations (Gong et al, 2014;Li et al, 2018;Gong et al, 2020). Patients with depression accompanied by suicidal tendencies also exhibit reductions in right precuneus FC compared with controls (Shu et al, 2022). Consistent with these findings, the present study found that adolescent MDD patients with a history of SA showed lower ALFF values in the precuneus relative to healthy controls, and negative correlations were observed between the precuneus ALFF values and both CDI and SIQ-JR scores.…”

Section: An Association Betweensupporting

confidence: 89%

Abnormal amplitude of low-frequency fluctuation values as a neuroimaging biomarker for major depressive disorder with suicidal attempts in adolescents: A resting-state fMRI and support vector machine analysis

Zhou¹,

Song

Chen³

et al. 2023

Front. Psychol.

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ObjectiveMajor depressive disorder (MDD) is associated with suicidal attempts (SAs) among adolescents, with suicide being the most common cause of mortality in this age group. This study explored the predictive utility of support vector machine (SVM)-based analyses of amplitude of low-frequency fluctuation (ALFF) results as a neuroimaging biomarker for aiding the diagnosis of MDD with SA in adolescents.MethodsResting-state functional magnetic resonance imaging (rs-fMRI) analyses of 71 first-episode, drug-naive adolescent MDD patients with SA and 54 healthy control individuals were conducted. ALFF and SVM methods were used to analyze the imaging data.ResultsRelative to healthy control individuals, adolescent MDD patients with a history of SAs showed reduced ALFF values in the bilateral medial superior frontal gyrus (mSFG) and bilateral precuneus. These lower ALFF values were also negatively correlated with child depression inventory (CDI) scores while reduced bilateral precuneus ALFF values were negatively correlated with Suicidal Ideation Questionnaire Junior (SIQ-JR) scores. SVM analyses showed that reduced ALFF values in the bilateral mSFG and bilateral precuneus had diagnostic accuracy levels of 76.8% (96/125) and 82.4% (103/125), respectively.ConclusionAdolescent MDD patients with a history of SA exhibited abnormal ALFF. The identified abnormalities in specific brain regions may be involved in the pathogenesis of this condition and may help identify at-risk adolescents. Specifically, reductions in the ALFF in the bilateral mSFG and bilateral precuneus may be indicative of MDD and SA in adolescent patients.

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“…Because it is one of the areas involved in the higher functional activities of the human brain, influencing social behavior, planning, language formation, working memory, language search, extraction, naming and other functional activities, it is closely related to many mental diseases. In addition, a study by Liu et al also suggested that spontaneous brain activity in the right MFG of patients with depression is significantly correlated with depressive symptoms (61). One of our previous studies also indicated that the changed of the FC between right praecuneus and MFG was related to improvement of depressive symptoms after cognitive-behavioral therapy combined with drugs (62).…”

Section: Discussionmentioning

confidence: 78%

“…In addition, a study by Liu et al also suggested that spontaneous brain activity in the right MFG of patients with depression is significantly correlated with depressive symptoms ( 61 ). One of our previous studies also indicated that the changed of the FC between right praecuneus and MFG was related to improvement of depressive symptoms after cognitive-behavioral therapy combined with drugs ( 62 ). The MFG is a core area of the DLPFC, which plays a key role in emotional supervision and cognitive processing ( 63 ).…”

Section: Discussionmentioning

confidence: 87%

A neuroimaging study of brain activity alterations in treatment-resistant depression after a dual target accelerated transcranial magnetic stimulation

Liu,

Shu,

et al. 2024

Front. Psychiatry

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In this study, we designed a new transcranial magnetic stimulation (TMS) protocol using a dual-target accelerated transcranial magnetic stimulation (aTMS) for patients with treatment resistant depression (TRD). There are 58 TRD patients were recruited from the Second People’s Hospital of Guizhou Province, who were, respectively, received dual-target (real continuous theta burst stimulation (cTBS) at right orbitofrontal cortex (OFC) and real repetitive transcranial magnetic stimulation (rTMS) at left dorsolateral prefrontal cortex (DLPFC)), single- target (sham cTBS at right OFC and real rTMS at left DLPFC), and sham stimulation (sham cTBS at right OFC and sham rTMS at left DLPFC). Resting-state functional magnetic resonance imaging (rs-fMRI) was acquired before and after aTMS treatment to compare characteristics of brain activities by use of amplitude of low-frequency fluctuations (ALFF), fractional low-frequency fluctuations (fALFF) and functional connectivity (FC). At the same time, Hamilton Depression Scale-24 (HAMD24) were conducted to assess the effect. HAMD24 scores reduced significantly in dual group comparing to the single and sham group. Dual-target stimulation decreased not only the ALFF values of right fusiform gyrus (FG) and fALFF values of the left superior temporal gyrus (STG), but also the FC between the right FG and the bilateral middle frontal gyrus (MFG), left triangular part of inferior frontal gyrus (IFG). Higher fALFF value in left STG at baseline may predict better reaction for bilateral arTMS. Dual-targe stimulation can significantly change resting-state brain activities and help to improve depressive symptoms.

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Changes of functional connectivity of the subgenual anterior cingulate cortex and precuneus after cognitive behavioral therapy combined with fluoxetine in young depressed patients with suicide attempt

Cited by 5 publications

References 43 publications

Postpartum depression and major depressive disorder: the same or not? Evidence from resting-state functional MRI

Postpartum depression and major depressive disorder: the same or not? Evidence from resting-state functional MRI

Abnormal amplitude of low-frequency fluctuation values as a neuroimaging biomarker for major depressive disorder with suicidal attempts in adolescents: A resting-state fMRI and support vector machine analysis

A neuroimaging study of brain activity alterations in treatment-resistant depression after a dual target accelerated transcranial magnetic stimulation

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