Changes of Dental Status in Patients With Malignant Tumor of Oropharyngeal Region During Antitumor Treatment

Валерьевна, Ижнина Екатерина; Кочурова, Е.В.; Сеферян, К Г

doi:10.25207/1608-6228-2017-24-5-111-119

Kuban. nauсh. med. vestnik

2017

DOI: 10.25207/1608-6228-2017-24-5-111-119

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Changes of Dental Status in Patients With Malignant Tumor of Oropharyngeal Region During Antitumor Treatment

Ижнина Екатерина Валерьевна¹,

Е.В. Кочурова²,

К Г Сеферян³

Abstract: Результаты. Состояние органов и тканей ОФЗ у пациентов со ЗНО на этапах противоопухолевого лечения ха-рактеризуется взаимосвязью между применяемой терапией и общесоматическим состоянием организма.Заключение. Комбинированное лечение ЗНО ОФЗ проявляется рядом непосредственных, ранних и отсрочен-ных реакций и повреждений, что необходимо контролировать на каждом этапе противоопухолевого лечения для повышения качества последующей стоматологической реабилитации данной категории пациентов. Results. The condition of … Show more

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Cited by 2 publications

References 13 publications

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Low level of the dental health as an indicator of malignant of the oral mucosa

Kochurova,

Nikolenko,

Kudasova

et al. 2024

Opuholi golovy i šei

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Introduction. The manifestation of oncological alertness during dispensary observation by a dentist is very important. The most accessible options for preventing malignancy of the oral mucosa are sanitation, regular professional oral hygiene, as well as educational work among doctors and the population. However, despite the visual accessibility of tissues and organs of the oral cavity, there is an annual increase in malignant neoplasms in this area. In this case, most patients are diagnosed with a tumor process of the last stage. malignant neoplasms of the head and neck organs require special attention due to high risk of disability even at an early stage. Aim. To evaluate a correlation between malignancy of the oral mucosa and the burdened dental status of patients. Materials and methods. A controlled study was conducted which included 142 patients with cancer of the oral mucosa without sequential or parallel inclusion of patients in groups. Dental status was assessed at help-seeking stage or during clinical examination, as planned, by evaluation of main dental indices. The morphological diagnosis was established using histological verification. Results. The majority of patients with oral tumors had hard dental plaque (81.7 % of cases). The condition of the soft tissues, in addition to presence of the mucous membrane lesion, was characterized by bleeding (69 % of cases). moderate periodontal pathology was detected (19 % of cases). patients with the cavity tumors had an acute traumatic edge of hard tissues (70 % of cases), extensive caries (26 % of cases) and the presence of removable dentures (82 % of cases). Conclusion. The values of parameters evaluated in patients in the study with squamous cell carcinoma of the oral mucosa show its relation to aggravation of general somatic status. All patients in the study required dental treatment and training in oral hygiene care.

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Low level of the dental health as an indicator of malignant of the oral mucosa

Kochurova,

Nikolenko,

Kudasova

et al. 2024

Opuholi golovy i šei

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View full text Add to dashboard Cite

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Expression of saliva biomarkers in patients with squamous cell carcinoma in various regions of the oral mucosa

Кочурова

Nikolenko

Panferova

et al. 2021

Russian Journal of Dentistry

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BACKGROUND: Oral fluid as a means for early detection and differential diagnosis of diseases of the oral mucosa and for assessing the overall somatic status of the body attracts the attention of researchers due to the non-invasiveness of material sampling and the exclusion of risks possible during blood analysis, as well as a simpler, compared with blood samples, material storage regime. AIM: The study aimed to evaluate the levels of oral fluid biomarkers of 170 patients with squamous cell carcinoma of the oral mucosa (RCC-MOP) depending on the localization of the oncopathology. MATERIALS AND METHODS: This study analyzed the levels of oral fluid biomarkers of 170 patients with RCC-MOP depending on the localization of oncopathology. Matrix metalloproteinases (MMPs) 2, 8, and 9, as well as their tissue inhibitors (TIMPs) 1 and 2, were chosen as biomarkers. For a comparative analysis, lesions of the tongue, cheek, floor of the oral cavity, alveolar ridge of the jaw, and oropharynx were selected. RESULTS: The study showed significant differences in the biomarker levels in the localization of squamous cell carcinoma in different parts of the oral mucosa. CONCLUSIONS: Analysis of the expression of oral fluid biomarkers with RCC-MOP revealed a link between the localization of the oncopathology and the level of synthesized biomarkers. The peak values of MMPs in the lesions of the tongue and floor of the oral cavity may be associated with the high number of salivary glands in these anatomical areas. The expression level is influenced by a number of factors, such as the localization of the pathological process, dental status, age, gender, and general condition of the patient.

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Changes of Dental Status in Patients With Malignant Tumor of Oropharyngeal Region During Antitumor Treatment

Cited by 2 publications

References 13 publications

Low level of the dental health as an indicator of malignant of the oral mucosa

Low level of the dental health as an indicator of malignant of the oral mucosa

Expression of saliva biomarkers in patients with squamous cell carcinoma in various regions of the oral mucosa

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