Changes of cardiovascular risk factors and their implications in subsequent birth cohorts of older adults in Germany: a life course approach

Raum, Elke; Rothenbacher, Dietrich; Löw, Michael; Stegmaier, Christa; Ziegler, H; Brenner, Hermann

doi:10.1097/hjr.0b013e3282eeb308

Cited by 64 publications

(62 citation statements)

References 23 publications

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“…A further strength of the ESTHER study is its representativeness of a population that attends screenings. Nevertheless, the distribution of sociodemographic baseline characteristics and common prevalent chronic diseases in our study were similar to the distribution in the respective age categories in the German National Health Survey, which is a representative sample of the German population [21,22], a fact supporting the external validity of our study. FPG screening has been performed under conditions of routine medical practice.…”

Section: Risk For Incident Cardiovascular Eventssupporting

confidence: 81%

“…Study design This investigation is based on the 'Epidemiologische Studie zu Chancen der Verhütung, Früherkennung und optimierten Therapie chronischer Erkrankungen in der älteren Bevölkerung' [Epidemiological investigations of the chances of preventing, recognising early and optimally treating chronic diseases in an elderly population] (ESTHER) study, an ongoing cohort study, details of which have been reported elsewhere [21,22]. Briefly, 9,949 individuals, aged 50-74 years at baseline, were recruited by their general practitioners during a routine health check-up between 2000 and 2002 in the German federal state of Saarland.…”

Section: Methodsmentioning

confidence: 99%

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Fasting plasma glucose and HbA1c in cardiovascular risk prediction: a sex-specific comparison in individuals without diabetes mellitus

et al. 2012

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Section: Risk For Incident Cardiovascular Eventssupporting

confidence: 81%

Section: Methodsmentioning

confidence: 99%

Fasting plasma glucose and HbA1c in cardiovascular risk prediction: a sex-specific comparison in individuals without diabetes mellitus

et al. 2012

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“…In total, 9,949 participants, ages 50 to 74 years at baseline, were enrolled during a routine physician health checkup between 2000 and 2002. The distribution of sociodemographic characteristics, prevalent diseases, and major risk factors in the ESTHER study are comparable with those in the German National Health Survey which was conducted in a representative sample of the German population in 1998 (30). Blood samples were drawn during the health checkup, centrifuged, sent to the study center, and finally stored at À80 C until measurement.…”

Section: Study Design and Study Populationmentioning

confidence: 75%

Serum 25-Hydroxyvitamin D and Cancer Risk in Older Adults: Results from a Large German Prospective Cohort Study

Ordóñez‐Mena

Schöttker

Haug

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Several observational studies assessed the relationship between serum 25-hydroxyvitamin D [25(OH)D] concentrations and the risk of cancer but results were inconclusive.Methods: We measured 25(OH)D concentrations in a population-based cohort study of 9,949 men and women ages 50 to 74 years in Saarland, Germany. Comprehensively adjusted Cox regression models were applied to estimate HRs and 95% confidence intervals (CI) for the association between season-standardized 25 (OH)D concentrations and total and site-specific cancer incidence.Results: Overall, during a median of 8 years of follow-up, 873 subjects developed cancer; the most common being prostate (171), breast (137), lung (136), and colorectal (136) cancer. Low season-standardized 25(OH)D (<30, 35, 40, or 36 nmol/L in winter, spring, summer, and autumn, respectively) was neither significantly associated with total cancer incidence (HR, 1.10; 95% CI, 0.93-1.30) nor with site-specific cancer incidence. However, a significantly increased overall cancer risk was observed for low 25(OH)D among men, nonobese subjects and subjects reporting low fish consumption and for high 25(OH)D in nonsmokers and nonobese subjects. Accordingly, restricted cubic splines to investigate dose-response relationships curves showed an inverse association of 25(OH)D levels and total cancer risk in men but not in women.Conclusions: 25(OH)D concentrations were significantly associated with overall cancer incidence in subgroups of this large cohort from Germany. No significant association was observed with site-specific cancers but this could be due to a limited statistical power for these endpoints.Impact: Further research should clarify whether and to what extent specific risk groups might profit from vitamin D supplementation. Cancer Epidemiol Biomarkers Prev; 22(5); 905-16. Ó2013 AACR.

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“…Detailed information on the study design and the study population has been reported elsewhere [13,14]. Briefly, baseline assessment was conducted between July 2000 and December 2002 and included 9,949 participants aged 50-75 years, recruited by their general practitioner.…”

Section: Methodsmentioning

confidence: 99%

Association between Oxidative Stress and Frailty in an Elderly German Population: Results from the ESTHER Cohort Study

et al. 2015

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Background: Oxidative stress (OS) and inflammatory biomarkers have been postulated to be important factors in the development of age-related diseases. While causes of frailty are complex and multidimensional based on the interaction of genetic, biological, physical, and environmental factors, the biological basis of frailty has been difficult to establish. Objective: In this study, we aimed to assess the possible association between different OS and inflammatory biomarkers and frailty. Methods: This cross-sectional analysis was performed among 2,518 subjects participating in a large population-based cohort study on aging conducted in Germany. Frailty was assessed as proposed by Fried et al. [J Gerontol A Biol Sci Med Sci 2001;56:M146-M156]. OS biomarkers, biological antioxidant potential (BAP), derivate of reactive oxygen metabolites (d-ROM) and total thiol levels (TTL), and an established biomarker of inflammation C-reactive protein (CRP) were measured by spectrophotometry and immunoturbidimetry. Logistic regression models were performed to assess the relationship between the OS biomarkers and frailty status. Odds ratios (OR) and 95% confidence intervals (CI) were calculated to quantify the associations. Results: Mean levels of d-ROM, TTL, and CRP differed between frail and non-frail participants (p values <0.0001). Comparing highest and lowest quartiles of the biomarkers, statistically significant positive associations with frailty were observed for d-ROM (OR: 2.02, 95% CI: 1.25-3.25) and CRP (OR: 3.15, 95% CI: 2.00-4.96), respectively, after controlling for age and sex. An inverse statistically significant association with frailty was observed for TTL (OR: 0.42, 95% CI: 0.25-0.69). Conclusion: The strong associations with OS biomarkers and CRP support a major role of OS and inflammation in the development of frailty, which should be followed up in further longitudinal studies on frailty.

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Changes of cardiovascular risk factors and their implications in subsequent birth cohorts of older adults in Germany: a life course approach

Abstract: Women and men reaching old age in the forthcoming years have more unfavourable lifetime risk factor profiles than earlier birth cohorts. These patterns might have substantial implications for the future burden of chronic disease.

Cited by 64 publications

References 23 publications

Fasting plasma glucose and HbA1c in cardiovascular risk prediction: a sex-specific comparison in individuals without diabetes mellitus

Fasting plasma glucose and HbA1c in cardiovascular risk prediction: a sex-specific comparison in individuals without diabetes mellitus

Serum 25-Hydroxyvitamin D and Cancer Risk in Older Adults: Results from a Large German Prospective Cohort Study

Association between Oxidative Stress and Frailty in an Elderly German Population: Results from the ESTHER Cohort Study

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