Changes of Bone Mineral Content During Pregnancy and Lactation

Lamke, Bertil; Brundin, Jan; Moberg, Peter

doi:10.3109/00016347709162123

Cited by 148 publications

(59 citation statements)

References 6 publications

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“…Although there have been some reports on the effects of pregnancy on bone mass (1-6), since the measurement sites and techniques of bone mass measurement were different in each study, it is still con troversial whether bone mass decreases during preg nancy. However, it has been suggested in both the human and the rat studies that the axial bone mass might decrease during pregnancy (2)(3)(4), and that the appendicular bone mass does not decrease (2,5,6). In the present study, the BMD of the axial bone, which was lumbar spine, decreased during pregnancy.…”

Section: Discussioncontrasting

confidence: 55%

Change in Calcium Balance and Bone Mineral Density during Pregnancy in Female Rats.

Omi

Ezawa

2001

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThis study investigated changes in Ca balance and BMD during pregnancy in female rats. During pregnancy, the intestinal Ca absorption increased significantly, and Ca accumulation was also markedly elevated. However, BMD values for the lumbar spine de creased significantly during pregnancy. Twenty female SD rats, 10 weeks of age (Japan SLC Co., Shizuoka, Japan) were acclimated for 2 weeks. Then, the rats were divided into two groups; the control (no pregnancy) group (n=10) and the pregnant group (n=10). The rats in the pregnant group were kept in a cage with a male rat for 5 days at 12 weeks of age, and all 10 were successfully impregnated. During the pregnancy period, the values for intestinal Ca absorption and the rate of the intestinal Ca absorption in the pregnant group were signif icantly greater than those of the control group. In addition, in spite of the significant in crease in urinary Ca excretion in the pregnant group, the Ca accumulation was markedly elevated during the latter half of pregnancy. On the other hand, the BMD value in the lum bar spine for the pregnant group significantly decreased during pregnancy. These findings suggest that pregnancy accelerated intestinal Ca absorption and Ca accumulation in female rats, while the lumbar spine BMD decreased during pregnancy.

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Section: Discussioncontrasting

confidence: 55%

Change in Calcium Balance and Bone Mineral Density during Pregnancy in Female Rats.

Omi

Ezawa

2001

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Several investigators, including ourselves, have reported that bone mineral density decreases during pregnancy or puerperium [1,[14][15][16][17][18][19]. As we mentioned previously [1], the reason for increased bone turnover during pregnancy despite a hyperestrogenic environment is unclear.…”

Section: Assay For Ctx Ntx and Other Markers In Urinementioning

confidence: 76%

Changes in Urinary Excretions of C-Telopeptide and Cross-Linked N-Telopeptide of Type I Collagen during Pregnancy and Puerperium.

1997

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increased in the 3rd trimester of pregnancy and at 1 month of puerperium compared with that in the early stage of pregnancy (P<0.05). These results further confirm our previous evidence that bone resorption is enhanced during the 3rd trimester of gestation and puerperium and suggest that urinary CTX and NTX measured by ELISA, which is more convenient than HPLC, are useful markers to assess bone resorption during peripuerperal periods.

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“…This reduction during lactation is seen in most of the reports that have studied this subject. 19,22,24,25 Sowers et al 26 verified a reduction in bone mineral density among women that suckled for more than 6 months, with the return to the basal level of bone mineral density occurring 12 months after childbirth. The reduction in bone mineral density during lactation is explained by the decrease in estrogen levels due to the decrease in follicle-stimulating hormone (FSH), caused by the increase of prolactin.…”

Section: Discussionmentioning

confidence: 99%

Osteoporotic fractures of proximal femur: clinical and epidemiological features in a population of the city of São Paulo

et al. 2001

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CONTEXT: It is believed that about 25% of menopausal women in the USA will exhibit some kind of fracture as a consequence of osteoporosis. Fractures of the proximal femur are associated with a greater number of deaths and disabilities and higher medical expenses than all the other osteoporotic fractures together. OBJECTIVE: To study the clinical and epidemiological features of patients with proximal femur fracture in hospitals in São Paulo. DESIGN: Transversal and retrospective study. LOCAL: Hospital São Paulo and Hospital Servidor Público Estadual "Francisco Morato Oliveira". PARTICIPANTS: Patients aged sixty-five years or more hospitalized because of proximal femur fracture, from March to November 1996 (N = 73). This group was compared to patients of the same age without fracture of the proximal femur. INTERVENTION: Evaluation of weight, height, body mass index; lifestyle habits (physical activity at home, ingestion of dairy calcium, drinking of coffee, smoking habit), gynecological history (ages at menarche and menopause, number of pregnancies and lactations), previous morbidity, use of medications, history of previous fractures, family history of osteoporosis. MEASUREMENT: The comparison of the different data regarding lifestyle habits between the two groups was made using the chi-squared test. Other data were analyzed using the Mann -- Whitney test. P £ 0.05 was considered significant. RESULTS: We noted a predominance of proximal femur fracture among females in relation to males (a female/male ratio of 3.3:1) with a progressive increase in the frequency of proximal femur fracture with age in both sexes. The group with proximal femur fracture, in comparison with the control group, showed a lower body mass index, less physical activity, and a greater number of pregnancies and lactations. Other data were not different. CONCLUSION: In accordance with the literature, we found a predomination of proximal femur fracture in women in relation to men, and a favorable effect of higher body mass index and physical activity for decreasing the frequency of proximal femur fracture. We also discuss the role of pregnancies and lactation on the frequency of proximal femur fracture.

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Changes of Bone Mineral Content During Pregnancy and Lactation

Cited by 148 publications

References 6 publications

Change in Calcium Balance and Bone Mineral Density during Pregnancy in Female Rats.

Change in Calcium Balance and Bone Mineral Density during Pregnancy in Female Rats.

Changes in Urinary Excretions of C-Telopeptide and Cross-Linked N-Telopeptide of Type I Collagen during Pregnancy and Puerperium.

Osteoporotic fractures of proximal femur: clinical and epidemiological features in a population of the city of São Paulo

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