Changes of biochemical parameters in blood serum rats under chronic light desynchronosis

Батоцыренова, Е. Г.; Zolotoverkhaja, E A; Kashuro, V. A.; Шарабанов, А. В.

doi:10.18097/pbmc20206606450

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…В целях моделирования десинхроноза с изменённым световым режимом проводили опыты на белых беспородных крысах-самцах (возраст -2 мес., масса -160-200 г) [10]. Одновременно включённым в контрольную и опытную группы крысам вводили депримирующий яд -тиопентал натрия в дозе ЛД 50 (85 мг/кг массы животного, в/б).…”

Section: материал и методыunclassified

The Eﬃcacy of a Peptide Product from the Pituitary Gland of <i>Rangifer tarandus</i> as an Antioxidant Agent Under the Combined Eﬀects of Light Desynchronosis and Depriming Toxicant

Батоцыренова

Kashuro

Шарабанов

et al. 2021

A&Ch

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The possibility of using methods for determining the oxidative status of an organism (enzymatic and non-enzymatic links of the cellular antioxidant system) to assess the antioxidant properties of peptides of the pituitary gland of the reindeer (Rangifer tarandus) were investigated in an experimental study conducted with a combined eﬀect of factors of diﬀerent nature on rats: a physical factor — prolonged light desynchronosis (diﬀerent light modes) and a chemical factor - acute severe poisoning with depriving toxicant (sodium thiopental, LD50). The pharmacological correction of the oxidative status of cells in the animals of the experimental subgroups was carried out with the peptide product of the pituitary gland, intranasally injecting the surviving rats with the bioproduct at a dose of 100 µg/kg, once in the ﬁrst half of the objective day for 14 days after poisoning with sodium thiopental. The surviving animals of the control groups were similarly injected with saline. The eﬀectiveness of the correction of the disruptions of the cellular oxidative status with the peptide product of the pituitary gland was tested 30 days after the onset of the combined eﬀect of stress factors on rats. It was found that the use of this bioactive peptide product in experimental animals exposed to diﬀerent light modes and a chemical factor contributed to a decrease in the initially increased indicators of lipid peroxidation in rat erythrocytes and an increase in the initially reduced indicators of the enzymatic link of antioxidant protection. The activity of superoxide dismutase, glutathione peroxidase, glutathione transferase, as well as glucose-6-phosphate dehydrogenase increased after pharmacological correction. The concentration of reduced glutathione also increased in erythrocytes. The maximum changes were observed in the experimental subgroup of rats exposed to the combined eﬀects of constant illumination and depriming toxicant. It was also found that the revealed positive changes in the indicators of the enzymatic link of antioxidant protection in animals of the experimental subgroups are associated with the maintenance of a suﬃcient concentration of reduced glutathione in red blood cells, which contributed to the maintenance of the cellular redox balance, when the conditions of the external lighting regime are violated.

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Section: материал и методыunclassified

The Eﬃcacy of a Peptide Product from the Pituitary Gland of <i>Rangifer tarandus</i> as an Antioxidant Agent Under the Combined Eﬀects of Light Desynchronosis and Depriming Toxicant

Батоцыренова

Kashuro

Шарабанов

et al. 2021

A&Ch

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Pharmacological Correction of Long-Term Effects of Acute Severe Poisoning with Sodium Thiopental under Chronic Light Desynchronosis

2021

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We experimentally studied the possibility of using a peptide extract from the pituitary gland of a reindeer (Rangifer tarandus) to correct the functional state of the body under the combined effect of acute severe poisoning with sodium thiopental in rats, at a dose of LD50 under long-term light desynchronosis. The research was conducted using the statistical method of two-factor analysis of variance. It was found that, under constant light, a peptide extract from the pituitary gland of a reindeer affects such parameters as diene conjugates concentration, the activity of glutathione-S-transferase and glucose-6-phosphate dehydrogenase. Under prolonged darkness, the extract under study affected the activity of glutathione-S-transferase, glutathione peroxidase and glucose-6-phosphate dehydrogenase.

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Antioxidant Effects of Modified-Release Peptide Extracts in Correcting Light Desynchronosis

et al. 2022

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This research was aimed at creating novel domestic medical preparations with a modified release of active peptide substances obtained from renewable sources of biological materials. These preparations can be used for the purposes of pharmacological correction of desynchronosis by the action of biologically active substances on the processes of lipid peroxidation and antioxidant protection of cells in order to increase the body's resistance to the negative effects of various stress factors. The conducted studies have confirmed the efficacy of modified-release peptide extracts when correcting the body's oxidative status in various types of desynchronosis.

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Changes of biochemical parameters in blood serum rats under chronic light desynchronosis

Cited by 3 publications

References 4 publications

The Eﬃcacy of a Peptide Product from the Pituitary Gland of <i>Rangifer tarandus</i> as an Antioxidant Agent Under the Combined Eﬀects of Light Desynchronosis and Depriming Toxicant

The Eﬃcacy of a Peptide Product from the Pituitary Gland of <i>Rangifer tarandus</i> as an Antioxidant Agent Under the Combined Eﬀects of Light Desynchronosis and Depriming Toxicant

Pharmacological Correction of Long-Term Effects of Acute Severe Poisoning with Sodium Thiopental under Chronic Light Desynchronosis

Antioxidant Effects of Modified-Release Peptide Extracts in Correcting Light Desynchronosis

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