The management and control of food waste is currently seen as a growing concern, anaerobic digestion is a promising alternative for the valorization of food waste. This study evaluates the effect of the application of three pretreatments (grinding, pH control, thermal treatment) and organic load control, employing a high alkalinity inoculum for methane production through BMP tests, using a Taguchi L8 experimental design of 4 factors and 2 levels, resulting in the best performance (65.91 NmL •g -1 TVS) with pretreatment conditions of grinding with fine particle size, pH 11, thermal pretreatment at 60 °C and a concentration of 14 g TVS •L -1 ,w h i c h represents an improvement of 34.66% in comparation with the food waste without pretreatments.