Changes in zinc status and zinc transporters expression in whole blood of patients with Systemic Inflammatory Response Syndrome (SIRS)

Florea, Daniela; Molina-López, Jorge; Högstrand, Christer; Lengyel, Imre; Cruz, A. Pérez de la; Rodrı́guez-Elvira, Manuel; Planells, Elena

doi:10.1016/j.jtemb.2017.11.013

Cited by 20 publications

(16 citation statements)

References 29 publications

(45 reference statements)

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“…Zinc serves as an important structural element for many proteins and is required by enzymes involved in transcription and translation. Therefore, the higher synthesis rate of APP in the liver could cause an increased requirement for zinc during APR [ 56 , 57 , 58 ]. With respect to cytokine production a knockout (k.o.)…”

Section: Zinc Homeostasis During Sepsismentioning

confidence: 99%

“…In this context it is of interest to mention that several studies have shown a correlation between a patient’s serum zinc concentration and the severity of the inflammatory response or sepsis. In critically ill patients, those with a high SOFA score showed a significantly lower serum zinc concentration than patients with a low SOFA score, whereby a higher SOFA score was associated with higher mortality [ 2 , 58 ]. In line with these results serum zinc concentrations were found to be inversely correlated with the SOFA score in other studies, as well [ 39 , 77 ].…”

Section: Zinc Homeostasis During Sepsismentioning

confidence: 99%

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Zinc and Sepsis

Alker

Haase

2018

Nutrients

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Sepsis, defined as a “life-threatening organ dysfunction caused by a dysregulated host-response to infection” is a major health issue worldwide and still lacks a fully elucidated pathobiology and uniform diagnostic tests. The trace element zinc is known to be crucial to ensure an appropriate immune response. During sepsis a redistribution of zinc from serum into the liver has been observed and several studies imply a correlation between zinc and sepsis outcome. Therefore the alterations of zinc concentrations in different tissues might serve as one part of the host’s defense mechanism against pathogens during sepsis by diverse mechanisms. It has been suggested that zinc is involved in nutritional immunity, acts as a hepatoprotective agent, or a differentiation signal for innate immune cells, or supports the synthesis of acute phase proteins. Further knowledge about these events could help in the evaluation of how zinc could be optimally applied to improve treatment of septic patients. Moreover, the changes in zinc homeostasis are substantial and correlate with the severity of the disease, suggesting that zinc might also be useful as a diagnostic marker for evaluating the severity and predicting the outcome of sepsis.

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Section: Zinc Homeostasis During Sepsismentioning

confidence: 99%

Section: Zinc Homeostasis During Sepsismentioning

confidence: 99%

Zinc and Sepsis

Alker

Haase

2018

Nutrients

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“…Die Serum-Zink-Konzentration ist kein zuverlässiger Indikator für den individuellen Zinkstatus [18]. Sie kann insbesondere bei Entzündungen oft zu niedrig sein [40].…”

Section: Bestimmung Von Zink Im Plasma Oder Serumunclassified

“…Sie kann insbesondere bei Entzündungen oft zu niedrig sein [40]. Ursache dafür ist vermutlich eine verminderte Produktion von Zinktransportern im Rahmen von Entzündungsreaktionen [18], die u. a. durch proinflammatorische Zytokine wie In-terleukin-6 vermittelt wird [26]. Eine andere denkbare Erklärung könnte eine entzündungsbedingte Verlagerung des Zinks vom Blut in die Leber sein [40].…”

Section: Bestimmung Von Zink Im Plasma Oder Serumunclassified

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Zinkmangel im Fokus: Ursachen, Symptome, Diagnose und Therapie

Gröber¹,

Kisters²,

Classen³

2019

EHK

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Association Between Low Zinc Levels and Severity of Acute Respiratory Distress Syndrome by New Coronavirus SARS‐CoV‐2

Gonçalves¹,

Gonçalves²,

Guarnieri³

et al. 2020

Nut in Clin Prac

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Background We verify the prevalence of low zinc levels among critically ill patients infected by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) in the intensive care unit (ICU) who required invasive mechanical ventilation, as well as its association with severity of acute respiratory distress syndrome (ARDS). Methods This is an observational study composed of patients admitted to the ICU. Demographics, anthropometric data for calculating body mass index (BMI), and laboratory data were obtained at admission: blood count, ferritin, arterial blood gas, serum zinc levels, and C‐reactive protein. Also, arterial oxygen tension (PaO2) divided by fractional inspired oxygen (FiO2) was calculated by the first arterial blood gas after intubation. A diagnosis of severe ARDS was determined if the PaO2/FiO2 ratio was ≤100 mm Hg. Low zinc levels were established if zinc levels were <70 μg/dL. Results A total of 269 patients met inclusion criteria; 51.3% were men; median age was 74 (66–81) years; 91.1% (245 of 269) were elderly. The median BMI was 30.1 (24.7–32.1) kg/m2, with 59.9% (161 of 269) of patients having overweight and obesity. The prevalence of low zinc levels was 79.6% (214 of 269) and severe ARDS was 56.5% (152 of 269). There was an association of low zinc levels and severe ARDS (odds ratio [OR], 14.4; 95% CI, 6.2–33.5; P < .001), even after adjusting for baseline variables (OR, 15.4; 95% CI, 6.5–36.3; P < .001). Conclusion Critically ill patients infected by SARS‐CoV‐2 with severe ARDS have a high prevalence of low serum zinc levels.

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Changes in zinc status and zinc transporters expression in whole blood of patients with Systemic Inflammatory Response Syndrome (SIRS)

Cited by 20 publications

References 29 publications

Zinc and Sepsis

Zinc and Sepsis

Zinkmangel im Fokus: Ursachen, Symptome, Diagnose und Therapie

Association Between Low Zinc Levels and Severity of Acute Respiratory Distress Syndrome by New Coronavirus SARS‐CoV‐2

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