Changes in vitamin a status following prolonged immobilization (simulated weightlessness)

Takase, Sachiko; Goda, Toshinao; Yokogoshi, Hidehiko; Hoshi, Takeshi

doi:10.1016/0024-3205(92)90541-v

Cited by 13 publications

(4 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most marked differences in the retinol peak occurred in the largest droplets (AEM livers with the largest droplets had the most retinol signal) and livers of AEM mice had more HSCs containing membrane-free lipid droplets, again supporting the potential for early-stage HSC activation. Remarkably, altered retinol levels and concomitant fatty liver was observed in rats subjected to 14 days of hindlimb suspension, the “gold standard” ground-based spaceflight analog for microgravity [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Spaceflight Activates Lipotoxic Pathways in Mouse Liver

et al. 2016

View full text Add to dashboard Cite

Spaceflight affects numerous organ systems in the body, leading to metabolic dysfunction that may have long-term consequences. Microgravity-induced alterations in liver metabolism, particularly with respect to lipids, remain largely unexplored. Here we utilize a novel systems biology approach, combining metabolomics and transcriptomics with advanced Raman microscopy, to investigate altered hepatic lipid metabolism in mice following short duration spaceflight. Mice flown aboard Space Transportation System -135, the last Shuttle mission, lose weight but redistribute lipids, particularly to the liver. Intriguingly, spaceflight mice lose retinol from lipid droplets. Both mRNA and metabolite changes suggest the retinol loss is linked to activation of PPARα-mediated pathways and potentially to hepatic stellate cell activation, both of which may be coincident with increased bile acids and early signs of liver injury. Although the 13-day flight duration is too short for frank fibrosis to develop, the retinol loss plus changes in markers of extracellular matrix remodeling raise the concern that longer duration exposure to the space environment may result in progressive liver damage, increasing the risk for nonalcoholic fatty liver disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Spaceflight Activates Lipotoxic Pathways in Mouse Liver

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Nevertheless, they had a decline in body weight gain which was proportional to the decrease in food intake. These alterations, however, seems to be of minor significance in comparison with other experimental models of stress (Takase, Goda, Yokogoshi & Hoshi, 1992;Marti et al 1993). The reduction in body weight gain that accompanies chronic immobilization is usually more pronounced in stressed than in pair-fed rats (Marti et al 1993) and has been attributed to the metabolic activity of high corticosterone secretion (Alario, Gamallo, Beato & Trancho, 1987), although the thermogenic effect of noradrenaline (norepinephrine) (Rothwell & Stock, 1982) should be also considered.…”

Section: Discussionmentioning

confidence: 70%

Chronic intermittent immobilization of male rats throughout sexual development: a stress protocol

Almeida¹,

Anselmo-Franci²,

Silva³

et al. 1998

Experimental Physiology

View full text Add to dashboard Cite

SUMMARYA stress protocol -6 h of daily immobilization -was applied throughout male rat sexual development. Immobilization caused a small reduction in food intake and body weight gain whereas pair-fed animals had a marginal decrease only in body weight gain. Stress, confirmed by increased plasma adrenocorticotrophic hormone (ACTH) and corticosterone, caused a decrease in plasma luteinizing hormone (LH) after 15 and 60 days of immobilization and in plasma testosterone after 60 days, but produced an opposite androgenic response in pubertal animals (15 days of immobilization). A presumed sympathetic over-stimulation is suggested to account for increased testosterone levels in pubertal stressed rats.

show abstract

“…Organs were weighed to assess any systemic effects of the different implant sizes. For example, animals enduring chronic pain or distress may have smaller thymus glands and spleens and larger adrenal glands (1,11,24,29). Organ weights from phase 1 were similar among all groups.…”

Section: Discussionmentioning

confidence: 96%

Size constraints of telemeters in rats

Moran¹,

Roy

Wade

et al. 1998

Journal of Applied Physiology

View full text Add to dashboard Cite

This study was designed to determine the maximum-size subcutaneous telemeter that would enable long-term and multichannel data collection in a 170-g rat for 90 days. In phase 1, rats with implants weighing 5 (2.5 cm3), 15 (7.5 cm3), 25 (12.5 cm3), 35 (17.5 cm3), or 45 (22.5 cm3) g were compared with sham-operated (SOC) and nonoperated (NOC) control animals. Severe skin lesions, seromas, and lower growth rates were observed in rats having implants >/=35 g. Thus, in phase 2, rats implanted with 23.5 g (17.5 cm3; 11-g active telemeter and 12.5-g implant) were compared with rats implanted with 11 g (6 cm3; telemeter only) and with the SOC and NOC groups. No differences were found among implanted groups in mean arterial pressure (MAP), heart rate (HR), subcutaneous temperature, or spontaneous activity under standard housing conditions. All groups were more active and had a higher MAP during the dark than the light phase of the daily cycle. During 2 h of cold exposure (3 degreesC), both telemetered groups exhibited similar changes in HR, MAP, temperature, and activity levels. Adrenal glands were larger in the 23.5-g group (51 +/- 1.6 mg) than in the SOC (46 +/- 1.0 mg) and the NOC groups (41 +/- 2.0 mg). No other significant differences were found in organ, muscle, or bone weights. These data verify the feasibility of using 23.5-g (17.5 cm3) subcutaneous telemeters for chronic recordings in young adult rats.

show abstract

Changes in vitamin a status following prolonged immobilization (simulated weightlessness)

Cited by 13 publications

References 24 publications

Spaceflight Activates Lipotoxic Pathways in Mouse Liver

Spaceflight Activates Lipotoxic Pathways in Mouse Liver

Chronic intermittent immobilization of male rats throughout sexual development: a stress protocol

Size constraints of telemeters in rats

Contact Info

Product

Resources

About