Changes in visibility of intracranial arteries on MRA with normal ageing

Kusunoki, Katsusuke; Oka, Yoshihisa; Saito, M.; Sadamoto, Kazuhiko; Sakaki, Saburo; Miki, Hitoshi; Nagasawa, Kiyoshi

doi:10.1007/s002340050847

Cited by 18 publications

(12 citation statements)

References 13 publications

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“…16,17 A mild increase in vessel diameter with age could also explain, at least in part, the lower velocities observed in adults when compared with children with SCD. 18 We found an overall prevalence of 16% of intracranial stenoses detectable by MRA. In neurologically asymptomatic children with SCD, the frequency of stenoses detected by MRA is similar to our findings.…”

Section: Discussionmentioning

confidence: 63%

Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease

Silva

Vicari

Figueiredo

et al. 2009

Stroke

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Background and Purpose-Brain imaging abnormalities were reported in up to 44% of children with sickle cell disease (SCD). The prevalence of neuroimaging abnormalities in adult patients with SCD and their relationship to transcranial Doppler is still unclear. Our objectives were to study the frequency of MRI and MR angiography abnormalities in adults with SCD and to define what transcranial Doppler velocities are associated with intracranial stenoses detected by MR angiography. Methods-We examined all adult patients (Ͼ16 years) with SCD followed in the hematology outpatient clinic at our university hospital with MRI, MR angiography, and transcranial Doppler. Results-We evaluated 50 patients. The overall prevalence of MRI abnormalities was 60%. Abnormal MRI findings were more frequent when vessel tortuosity or stenoses were present on MR angiography (PϽ0.01). Patients with intracranial stenoses had significantly higher time-averaged maximum mean velocities (Pϭ0.01). A time-averaged maximum mean velocity of 123.5 cm/s allowed the diagnosis of middle cerebral artery or internal carotid artery intracranial stenosis with sensitivity of 100% and specificity of 73% with an area under the receiver operator characteristic curve of 0.91 (CI, 0.79 to 1.00). Conclusions-The frequency of brain imaging abnormalities detected by MRI/MR angiography in adults with SCD was higher than that described for children. Transcranial Doppler velocities in adult patients with intracranial stenoses were lower than those described for the pediatric population with SCD.

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Section: Discussionmentioning

confidence: 63%

Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease

Silva

Vicari

Figueiredo

et al. 2009

Stroke

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“…The decline in cerebral blood fl ow with advancing age may be associated with certain changes in cerebrovascular hemodynamics such as decreased metabolic demands, higher hematocrit and lower partial pressure of carbon dioxide levels (Melamed et al 1980), vessel-size changes (Kusunoki et al 1999), and lower cardiac output (Safar 1990). Several investigations demonstrated the importance of age on the TCD velocities (Arnolds and von Reutern 1986;Brouwers et al 1990).…”

Section: Discussionmentioning

confidence: 99%

Normal Blood Flow Velocities of Basal Cerebral Arteries Decrease with Advancing Age: A Transcranial Doppler Sonography Study

Demirkaya

Uluç

Bek

et al. 2008

Tohoku J. Exp. Med.

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Transcranial Doppler sonography (TCD) is a non-invasive diagnostic tool enabling evaluation of blood fl ow characteristics of basal intracerebral vessels via thin calvarian regions. Several factors may affect the normal values of cerebral hemodynamic parameters, and standard reference values for each laboratory are needed for precise interpretation of the results. The aims of this study were to determine normal values of fl ow velocities of basal cerebral arteries of our TCD laboratory, and to study the infl uence of age and gender on normal values. We studied 63 healthy volunteers (30 male and 33 females; age range, 5 -69 years old) with TCD with a 2-MHz transcranial probe. The subjects were divided into 7 age groups: 5-10 years, 11-20 years, 21-30 years, 31-40 years, 41-50 years, 51-60 years and > 60 years. Mean velocity (V mean), peak systolic velocity (PSV), and end-diastolic velocities (EDV) were determined in middle, anterior and posterior cerebral arteries. No signifi cant gender difference was found. However, there was a decrease in blood fl ow velocities in all vessels with advancing age, which was signifi cant when subjects older than 40 years and 40 years old were compared. V mean, PSV and EDV values were highest in the age group of 5 -10 years old and lowest in volunteers older than the age of 60 ( p < 0.05). As a conclusion, fl ow velocities in basal cerebral arteries range widely and are signifi cantly age-related. Age matching of TCD data is a requirement for clinically relevant conclusions.transcranial Doppler sonography; basal; cerebral arteries; normal values; healthy subjects. Tohoku

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“…The decline in CBFV with age may be associated with certain changes in cerebrovascular hemodynamics such as (1) decreased CBF or metabolic demands, 25,26 (2) vessel-size changes, 27 and (3) lower cardiac output. 28,29 Aging is associated with a 20% to 30% decrease in CBF in healthy individuals between the ages of 20 and 80 years.…”

Section: Effect Of Age On Cbfv and Pimentioning

confidence: 99%

“…30 Aging is also associated with dilatation of major extracranial arteries and reduction of flow within parenchymal vessels. 27 Kusunoki et al 27 demonstrated poor visibility of the intracerebral ICA and M1 segment of the MCA on magnetic resonance angiography secondary to progressive kinking, elongation, and stenosis with advancing age.…”

Section: Effect Of Age On Cbfv and Pimentioning

confidence: 99%

Effect of Age on Cerebral Blood Flow Velocity and Incidence of Vasospasm After Aneurysmal Subarachnoid Hemorrhage

Torbey

Hauser

Bhardwaj

et al. 2001

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Background and Purpose-Current transcranial Doppler criteria for vasospasm after aneurysmal subarachnoid hemorrhage are not age specific. We analyzed the effect of age on cerebral blood flow velocity changes after subarachnoid hemorrhage and constructed an age-adjusted predictive model of cerebral blood flow velocity in subarachnoid hemorrhage patients. Methods-We identified patients with aneurysmal subarachnoid hemorrhage admitted between 1991 and 1999 with a prospective transcranial Doppler database. Eighty-one patients, with complete medical records and transcranial Doppler examinations of the vessels of interest, were included. Patients were subdivided into 2 groups by age: younger, Ͻ68 years of age (nϭ47) and older, Ն68 years of age (nϭ34). Maximum mean flow velocity and incidence of symptomatic vasospasm were reported. Linear and nonlinear regression analyses were performed. Results-Middle cerebral artery and internal carotid artery mean flow velocity were lower in older patients (

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Changes in visibility of intracranial arteries on MRA with normal ageing

Cited by 18 publications

References 13 publications

Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease

Brain Magnetic Resonance Imaging Abnormalities in Adult Patients With Sickle Cell Disease

Normal Blood Flow Velocities of Basal Cerebral Arteries Decrease with Advancing Age: A Transcranial Doppler Sonography Study

Effect of Age on Cerebral Blood Flow Velocity and Incidence of Vasospasm After Aneurysmal Subarachnoid Hemorrhage

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