2001
DOI: 10.1097/00024382-200116050-00012
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Changes in Vascular Responsiveness to a Thromboxane Mimetic in Endotoxin Tolerance

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Cited by 3 publications
(2 citation statements)
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“…In rats rendered tolerant to lethal doses of endotoxin by repeated sublethal doses of endotoxin, the pressor response to phenylephrine was attenuated, but a higher peak response to U46619 was observed compared with controls (Coffee et al, 1991), although in the same model, the sensitivity of the response to U46619 in isolated aortic rings was reduced (Temple et al, 2001). The reason for these differences between the contractile agents is unclear, but one possibility is differences between their signaling pathways.…”
Section: Downloaded Frommentioning
confidence: 97%
“…In rats rendered tolerant to lethal doses of endotoxin by repeated sublethal doses of endotoxin, the pressor response to phenylephrine was attenuated, but a higher peak response to U46619 was observed compared with controls (Coffee et al, 1991), although in the same model, the sensitivity of the response to U46619 in isolated aortic rings was reduced (Temple et al, 2001). The reason for these differences between the contractile agents is unclear, but one possibility is differences between their signaling pathways.…”
Section: Downloaded Frommentioning
confidence: 97%
“…Our previous studies demonstrated that in peritoneal macrophages from LPS-tolerant rat, GTPase activity, GTP g S binding, and protein content of G i3a and G i2a were significantly decreased. [61][62][63] In the same model, it was found that G i3a mRNA expression was also decreased. 64 Thus decreases of G i protein content and function in LPS-tolerant rat may be another manifestation of LPS tolerance.…”
Section: Proximal Post-receptor Signaling Protein Alterations In Endotoxin Tolerancementioning
confidence: 99%