Changes in urinary titin N-terminal fragments as a biomarker of exercise-induced muscle damage in the repeated bout effect

Yamaguchi, Sachi; Suzuki, Katsuhiko; Kanda, Koji; Inami, Takayuki; Okada, Junichi

doi:10.1016/j.jsams.2019.12.023

Cited by 13 publications

(20 citation statements)

References 27 publications

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“…Because muscle damage is inevitable after eccentric exercises, it became necessary to assess eccentric exercise-induced muscle damage for managing proper intensity of eccentric exercise training. A growing body of evidence has demonstrated that the urinary titin level is a non-invasive biomarker for muscle damage [10,12,20]. We also reported the changes in the urinary titin fragment levels in response to two dynamic eccentric exercises in this study.…”

Section: Drop Jumpsupporting

confidence: 58%

“…In this study, we found that changes in plasma CK, Mb, and the urinary titin fragment showed a similar pattern in response to both drop jump and eccentric ergometer exercise. Several recent stud-ies have also reported similar changes in circulating biomarkers for muscle damage and the urinary titin fragment in response to eccentric calf-raise [12] and elbow flexion [20][21][22] exercises, both of which are single-jointed eccentric movements. Kanda et al report- ed that the urinary titin fragment levels were increased after an acute bout of eccentric calf-raises exercise and the changes in the titin fragment were correlated with the changes of intramuscular proteins including serum CK, Mb, and lactate dehydrogenase [12].…”

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 82%

“…The changes of urinary titin fragment were correlated with that of serum CK, range of elbow flexor movement, muscle soreness, and maximum voluntary isometric contraction [22]. It has also been revealed that the urinary titin fragment sensitively reflected repeated bout effects [20]. On the other hand, we conducted two lower-limb dynamic eccentric exercises: the drop jump and eccentric ergometer exercise on the Cyclus2.…”

Section: Discussionmentioning

confidence: 94%

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Changes in Urinary Titin Fragment in Response to Different Types of Dynamic Eccentric Exercises

et al. 2020

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The urinary level of the titin fragment has been considered a non-invasive and sensitive biomarker for muscle damage in clinical cases. However, there is little evidence regarding changes in the urinary titin fragment in response to exercise-induced muscle damage. In this study, we aimed to investigate whether the urinary titin fragment reflects the magnitude of muscle damage induced by two lower-limb eccentric exercises. In this study, healthy young male subjects performed drop jump (n=9) and eccentric ergometer exercise (n=9). Blood and urine samples were collected at various time points before and after the exercises. Although perceived muscle soreness assessed by sit-to-stand tasks was increased at 24 h and 48 h after both drop jump and the eccentric ergometer exercise groups, the pressure pain threshold was not changed. Changes of the urinary titin fragment, plasma myomesin 3 fragments, creatine kinase (CK), and myoglobin (Mb) after the eccentric exercises were increased but not statistically significant. Meanwhile, we found that the changes in the urinary titin fragment levels in response to both drop jump and the eccentric ergometer exercise were correlated with those of plasma CK and Mb levels. These results provide evidence that the urinary titin fragment level is a non-invasive biomarker reflecting the magnitude of eccentric exercise-induced muscle damage.

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Section: Drop Jumpsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 94%

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Changes in Urinary Titin Fragment in Response to Different Types of Dynamic Eccentric Exercises

et al. 2020

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“…In another study, urinary titin N-fragment was correlated with age (r = 0.11, p = 0.04) [101]. Fourth, active exercise should be refrained from before the measurement of urinary titin N-fragment, because exercise increases the urinary titin N-fragment [105,106]. Due to the elastic property of titin, eccentric exercises are more injurious to the titin of muscles than concentric exercise [107].…”

Section: Picsmentioning

confidence: 99%

Urinary Titin N-Fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome

Nakanishi

Tsutsumi

Hara

et al. 2021

JCM

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Titin is a giant protein that functions as a molecular spring in sarcomeres. Titin interconnects the contraction of actin-containing thin filaments and myosin-containing thick filaments. Titin breaks down to form urinary titin N-fragments, which are measurable in urine. Urinary titin N-fragment was originally reported to be a useful biomarker in the diagnosis of muscle dystrophy. Recently, the urinary titin N-fragment has been increasingly gaining attention as a novel biomarker of muscle atrophy and intensive care unit-acquired weakness in critically ill patients, in whom titin loss is a possible pathophysiology. Furthermore, several studies have reported that the urinary titin N-fragment also reflected muscle atrophy and weakness in patients with chronic illnesses. It may be used to predict the risk of post-intensive care syndrome or to monitor patients’ condition after hospital discharge for better nutritional and rehabilitation management. We provide several tips on the use of this promising biomarker in post-intensive care syndrome.

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Urinary titin in myotonic dystrophy type 1

et al. 2023

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Introduction/Aims Urinary titin, an easy‐to‐obtain marker, has been investigated in muscular dystrophies, but not in myotonic dystrophy type 1 (DM1). We investigated the role of titin as a biomarker of muscle injury in DM1. Methods We compared the urinary titin N‐fragment/creatinine ratio in 29 patients with DM1 vs. 30 healthy controls. We also recorded clinical data such as muscle strength, serum creatine kinase, DM1‐related outcome measures, and the 20‐item DM1‐activ questionnaire. The severity of the disease was graded using the Muscular Impairment Rating Scale (MIRS). Results The titin/creatinine ratio was significantly higher in the urine samples of DM1 patients than of healthy controls (median ± mean absolute deviation [MAD]: 39.313 ± 26.546 vs. 6.768 ± 5.245 pmol/mg creatinine; P < .001), and was related to muscle impairment graded by MIRS (τ = 0.503, P = .038). Discussion Urinary titin may be a biomarker for DM1. Long‐term follow‐up of DM1 patients is needed to investigate the potential role of titin as a biomarker for disease activity and progression.

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Changes in urinary titin N-terminal fragments as a biomarker of exercise-induced muscle damage in the repeated bout effect

Cited by 13 publications

References 27 publications

Changes in Urinary Titin Fragment in Response to Different Types of Dynamic Eccentric Exercises

Changes in Urinary Titin Fragment in Response to Different Types of Dynamic Eccentric Exercises

Urinary Titin N-Fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome

Urinary titin in myotonic dystrophy type 1

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