Changes in Urinary Bone Resorption Markers (Pyridinoline, Deoxypyridinoline) Resulting from Experimentally-Induced Osteoarthritis in the Temporomandibular Joint of Rats

Imada, M.; Tanimoto, Kotaro; Ohno, Shigeru; Sasaki, Akira; Sugiyama, Hiroki; Tanne, Kazuo

doi:10.1080/08869634.2003.11746230

Cited by 13 publications

(8 citation statements)

References 28 publications

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“…However, it has been reported that a significant increase of Pyr was observed in urine of beagle dogs with aggressive local periodontitis induced by ligature of the gingival sulcus (34). Our previous studies have shown that the urinary Pyr/Dpyr ratio increases in collagenase‐induced experimental TMJ OA in the rat (35). Furthermore, a recent study demonstrated that urinary Pyr and Dpyr levels exhibited metabolic changes in mandibular growth (36).…”

Section: Discussionmentioning

confidence: 99%

Utility of urinary pyridinoline and deoxypyridinoline ratio for diagnosis of osteoarthritis at temporomandibular joint

Tanimoto

Ohno

Imada

et al. 2004

J Oral Pathology Medicine

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Section: Discussionmentioning

confidence: 99%

Utility of urinary pyridinoline and deoxypyridinoline ratio for diagnosis of osteoarthritis at temporomandibular joint

Tanimoto

Ohno

Imada

et al. 2004

J Oral Pathology Medicine

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“…The authors found that PD and PD to DPD ratio were significantly higher in the experimental group than control group. These findings showed that the markers would be available for the detection of degenerative changes in especially temporomandibular osteoarthritis [27]. Evalution of biochemical markers for monitoring the drug effects was also done.…”

Section: Clinical Usage Of Biochemical Markers In Oamentioning

confidence: 98%

Assessment of Disease Activity and Progression of Osteoarthritis With Using Molecular Markers of Cartilage and Synovium Turnover

Ofluoğlu¹,

Ofluoğlu²

2005

CRR

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Osteoarthritis (OA) is the most common joint disease, which is characterized by cartilage loss and concomitant alteration of synovium and subchondral bone metabolism. Pain and stiffness in the affected joints are the main complains. It also causes physical functional impairment. The measurement of joint space width by plain radiography is currently established method for assessing the progression of the disease. This method however has some limitations. The most important issue is to determine early OA before significant joint damage has occurred. When there is radiological evidence of OA, significant joint damage has often already occurred. Therefore, there is need for noninvasive methods that can be repeated and have better sensitivity than plain radiography to identify patients at high risk for destructive OA and monitoring drug efficacy.Molecular markers are released into biological fluids during tissue biosynthesis and turnover. They can be measured by immunoassay. Several molecular markers of bone, cartilage and synovium have been described such as crosslinking telopeptide of collagen type II (CTX II), Glc-Gal-PYD, hyaluronic acid, type I collagen.In conclusion, using a newly developed molecular marker, early OA can be properly detected before significant joint destruction has occurred.

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“…In addition to the conventional examinations, a highly advanced biochemical examination of urinary bone resorption markers (pyridinoline and deoxypyridinoline) has recently been used for the detection of bone or cartilage destruction in TMJ-OA [93,94]. During a series of treatment after differential diagnosis, we have to achieve TMJ unloading or the biomechanical equilibrium by means of condylar repositioning, if indicated, and the subsequent occlusal reconstruction without producing adverse influences on TMJ structures and functions [2,95].…”

Section: Clinical Implication and Concluding Remarksmentioning

confidence: 99%

Changes in Urinary Bone Resorption Markers (Pyridinoline, Deoxypyridinoline) Resulting from Experimentally-Induced Osteoarthritis in the Temporomandibular Joint of Rats

Cited by 13 publications

References 28 publications

Utility of urinary pyridinoline and deoxypyridinoline ratio for diagnosis of osteoarthritis at temporomandibular joint

Utility of urinary pyridinoline and deoxypyridinoline ratio for diagnosis of osteoarthritis at temporomandibular joint

Assessment of Disease Activity and Progression of Osteoarthritis With Using Molecular Markers of Cartilage and Synovium Turnover

Degenerative changes of articular cartilage in association with mechanical stimuli

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