Changes in Urinary 17-Hydroxycorticosteroid Excretion During Stressful Life Experiences in Man*

1 Introduction: Psychosocial Stimuli, Psychophysiological Reactions, and Disease

“…Increased adrenal cortical activity has been noted in response to hospitalization , anticipation of laboratory procedures (Mason, 1959;Persky et al, 1959), thoracic surgery (Price et al,, medical exams (Bliss et al, 1956), psychiatric interviews (Hetzel et al, 1955;Oken et al, 1960;Persky et al, 1958), pursuit-meter operation and psychological tests (Freeman et al, 1944;Korchin and Herz, 1960), motor-car driving (Frost et al, 1951;Hill et al, 1956), participation in flying activities (Craven and Smith, 1955;Male et al, 1958;Colehour, 1964), or in intense combat action (Elmadjian, 1955;Pace et al, 19-56), whereas viewing Disney nature-study films actually lowered the 17-hydroxycorticosteroids in plasma (Handlon et al, 1962).…”

The challenge of public health in Australia and the region

“…I was assigned to study the endocrine (adrenal, thyroid) and metabolic systems. I believe I was the first to report an increase in cortisone secretion in humans associated with emotional states such as apprehension and exhilaration 3 . These changes were accompanied by an increase in metabolic rate and other changes similar to those observed in physical trauma 4 …”

Urinary 17-Hydroxycorticoid and Uropepsin Levels with Psychological Data

“…[1][2][3][4][5][6] There have been few reports, however, concerning the physiological fluctuation of these substances over a relatively prolonged period of time in persons who have no clinically demonstrable endocrine abnormalities.…”