Changes in Tumor Blood Flow Produced by Microwave Induced Hyperthermia (Abstract)

Sutton, Carl H.; Carroll, F.B.

doi:10.1109/mwsym.1977.1124426

Cited by 2 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Song et al [2 11 and Emami et al [22] presented data from animal studies that implied no such response. However, Bicher et a1 [4], Sutton [23], Tanaka [24], and Johnson [25] demonstrated a heat-induced response in superficial human tumors as well as in animal tumors. Such a response implies that some tumors have preserved a thermoregulatory capability and cannot exhibit a significant temperature differential compared to normal tissues [l].…”

Section: Resultsmentioning

confidence: 99%

Blood flow in human tumors during hyperthermia therapy: Demonstration of vasoregulation and an applicable physiological model

Olch¹,

Kaiser²,

Silberman³

et al. 1983

Journal of Surgical Oncology

View full text Add to dashboard Cite

A quantitative assessment of the effect of localized magnetic-loop hyperthermia on blood flow was performed in 12 human tumors using the 133Xe clearance method. Because blood flow in these tumors changed in response to needle injection, a physiologically based, one-compartment model was developed that included both a hyperemic and a steady-state component. In six tumors, changes in blood flow induced by heat were also observed. The ability of tumor vessels to respond dynamically to stress and the degree of response may be predictive of tumor heating capacity and subsequent therapeutic response.

show abstract

Section: Resultsmentioning

confidence: 99%

Blood flow in human tumors during hyperthermia therapy: Demonstration of vasoregulation and an applicable physiological model

Olch¹,

Kaiser²,

Silberman³

et al. 1983

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

“…Tumor-bearing mice were put into methacrylate cages [Dietzel, 1975a;Szmigielski et al, 1976b] and in vivo [Dietzel, 1975, Sutton, 1976 ials [Coley, 1893;Okamoto et al, 1966Okamoto et al, , 1972Okamoto et al, , 1976]. Hahn, E. W., A.…”

Section: Microwave [Mw] Hyperthermiamentioning

confidence: 99%

“…Neoplastic cells aroe more sensitive to temperatures in the range 40 to 45 C than are normal cells [Cavaliere et al, 1967;Dickson and Shah, 1972]. Hyperthermia, both general [Ardenne, 1971] and local [Dietzel, 1975a;Dietzel et al, 1973;Overgaard and Overgaard, 1972] inhibits growth of tumors or produces necrosis of tumorous tissues, depending on intensity and duration of heating, therapeutic schedule and whether there is adjuvant treatment with other antineoplastic agents [Dietzel, 1975a;Leveen et al, 1976;Sutton, 1976]. Microwave irradiation offers a unique source of thermal energy for general or local hyperthermia of living organisms due to deeper penetration into tissues [Guy et al, 1974;Justesen and King, 1970].…”

Section: Introductionmentioning

confidence: 99%

“…Microwave irradiation offers a unique source of thermal energy for general or local hyperthermia of living organisms due to deeper penetration into tissues [Guy et al, 1974;Justesen and King, 1970]. Microwave energy has recently been used to inhibit growth of tumors both in experimental animals [Dietzel et al, 1973;Overgaard and Overgaard, 1972;Sutton, 1976;Szmigielski, 1977;Szmigielski et al, 1976a] and, under less-controlled conditions, in patients suffering from neoplasms [Bull and Chretien, 1976;Hymen and Wieland, 1976;Leveen et al, 1976].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inhibition of tumor growth in mice by microwave hyperthermia, Streptolysin S and Colcemide

Szmigielski¹,

Pulverer²,

Hryniewicz³

et al. 1977

Radio Science

View full text Add to dashboard Cite

Mice with transplanted Sarcoma 180 were irradiated 2 hours daily; 1st through 14th day after transplantation with 3‐GHz microwaves at a power density of 40 mW/cm2. The irradiation resulted in an increase of rectal temperature by 3 to 4 °C. Some animals that were exposed to radiation received daily an IP injection of 1 mg/kg of Colcemide (synthetic Colchicine) or of 0.5 mG/kg of purified Streptolysin S or of both compounds. On the 14th day after transplantation half of each group of mice received 1 μCi/g IP 3H‐thymidine; the other halves 3H‐uridine, 1 μCi/g IP. Three hours later all of the mice were killed; the tumors were dissected, then measured for mass and radioactivity. Mean tumor mass, number of regressed tumors and averaged counts of radioactivity were calculated for each group. Microwave hyperthermia resulted in reduction of tumor mass by about 40%; the reduction was enhanced when microwave hyperthermia was combined with Colcemide and/or Streptolysin S. In the combined treatment with all three factors the tumor mass was reduced by about 70%. Inhibition of the tumor's growth was accompanied by reduced uptake of 3H‐thymidine and 3H‐uridine into the tumorous tissues.

show abstract

Changes in Tumor Blood Flow Produced by Microwave Induced Hyperthermia (Abstract)

Cited by 2 publications

References 0 publications

Blood flow in human tumors during hyperthermia therapy: Demonstration of vasoregulation and an applicable physiological model

Blood flow in human tumors during hyperthermia therapy: Demonstration of vasoregulation and an applicable physiological model

Inhibition of tumor growth in mice by microwave hyperthermia, Streptolysin S and Colcemide

Contact Info

Product

Resources

About