Changes in the Temperament and Character Inventory dimensions after paroxetine treatment in patients with major depressive disorder

Abstract

Previous studies have reported changes in the dimensions of the Temperament and Character Inventory (TCI) after patients with major depressive disorder are treated. We aimed to investigate the changes in the TCI dimensions after paroxetine treatment in patients with major depressive disorder. Forty-eight patients were enrolled in this study and were treated with 10-40 mg/day of paroxetine for 6 weeks. The TCI was completed twice, at weeks 0 and 6. We used the Montgomery-Asberg Depression Rating Scale (MADRS) to evaluate patients. The participants were divided into three groups (responders, non-responders, and early responders) based on treatment response. The scores of each dimension of the TCI were compared before and after treatment using repeated-measures two-way analyses of variance. In the responders group (n = 24), no TCI dimension scores changed significantly during treatment, but the interaction between sex and MADRS score change was significantly associated with the results. In the non-responders group (n = 15), the self-directedness score increased significantly during the treatment period (p = 0.000), and the change in MADRS score significantly affected the results. In the early responders group (n = 9), no TCI dimension scores changed significantly during treatment. The results of the present study may reveal a possible correlation between paroxetine treatment and changes in personality traits.

Effects of personality on the association between paroxetine plasma concentration and response

“…It is unclear why patients with high HA or low SD scores exhibited a negative association between paroxetine plasma concentration and MADRS improvement rate. In a previous study investigating changes of TCI traits pre- and posttreatment for patients with depression using paroxetine, only SD scores of nonresponders increased significantly, and others did not show significant change 34. Although we did not find a reason for the results in this previous study, the mechanisms might have been similar to the negative associations in the present study.…”

Temperament and character influence on depression treatment outcome

“…The compliance in long term therapies as well, generally required to achieve and maintain the remission state, could be impaired by low P scores (Li et al, 2018), particularly when more than one treatment was prescribed, especially in case of TRD. Indeed, high P scores were related to response to rTMS in TRD-MDD patients (Siddiqi et al, 2016), while most studies focusing on non response reported negative results (Tomita et al, 2015, Takahashi et al, 2013a, Kampman and Poutanen, 2011.…”

“…Positive results were also reported for Persistence (P), Reward Dependence (RD), Cooperativeness (C) and Self Transcendence (ST), where the association with depression outcome mainly resulted from changes in trait scores after AD treatment and specifically in responder subjects (Paavonen et al, 2018, Takahashi et al, 2013a, Corruble et al, 2002, Sato et al, 1999. However, most part of studies investigating such personality traits in the prediction of response failed to confirm these findings (Tomita et al, 2015, Kampman and Poutanen, 2011, Mulder, 2002. Interestingly, low P was found to predict, even if minimally, poor response to Cognitive Behavioural Therapy (CBT), while high HA and low RD and SD seemed to predict negative response to Interpersonal Therapy (IPT) (Joyce et al, 2007).…”

Correlations between Personality Traits, Patient-Reported Outcome, and Chronic Prostatitis Symptoms in Men with Different Premature Ejaculation Syndromes

“…As the internal organization of affective, emotional, cognitive, and conceptual systems, personality could determine human unique repose to the environment. Temperament and Character Inventory (TCI) scale is widely used to measure personality [13][14][15]. It has provided a comprehensive biopsychosocial model of personality and divided personality into seven dimensions that vary widely in the general population [16].…”