Changes in the ST waveform of the fetal lamb electrocardiogram with hypoxemia

Greene, Kate; Dawes, G. S.; Lilja, Håkan; Rosén, Karl G.

doi:10.1016/0002-9378(82)90190-9

Cited by 97 publications

(65 citation statements)

References 17 publications

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“…Finally, earlier studies from our group have revealed ST waveform changes with increasing T wave amplitude related to anaerobic glycogenolysis in the myocardium, an effect of betaadrenoceptor stimulation [12,13], a pattern otherwise seen during fetal asphyxia [7]. A strong correlation between T wave amplitude and circulating adrenaline has also been found [26].…”

Section: Discussionsupporting

confidence: 55%

“…Both groups also noticed, in single animals, that decreasing FHRV again were seen in connection with severe hypoxemia. Waveform changes in the ST segment of the fetal electrocardiogram (FECG) constitute another sensitive parameter of hypoxic stress, where the dominant reaction is a progressive increase in the T wave amplitude, and where the changes can be quantified as the T/QRS ratio [7]. In the fetal lamb the FECG alterations have been correlated to the depletion of myocardial glycogen stores, thus reflecting anaerobic myocardial glycolysis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Heart rate variability and electrocardiogram changes in the fetal lamb during hypoxia and beta-adrenoceptor stimulation

Lilja¹,

Karlsson²,

Kjellmer³

et al. 1984

Journal of Perinatal Medicine

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Heart rate variability and electrocardiogram changes in the fetal lamb during hypoxia and beta-adrenoceptor stimulation

Lilja¹,

Karlsson²,

Kjellmer³

et al. 1984

Journal of Perinatal Medicine

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“…In studies by Rosen et al as well as Greene et al, changes in the ST segment and shape of the T wave during acute hypoxia were described jointly with a drop in the amount of glycogen and ATP in the myocardium and a rise of potassium and lactate in the plasma [21,22]. An inverse relationship was observed between T/QRS values and the pH of umbilical cord blood sampled during labor [22]. Currently, in many health care centers attempts to use fetal ECG in combination with CTG during labor have been undertaken.…”

Section: Discussionmentioning

confidence: 98%

“…Similar symptoms were observed also in the state of acute hypoxia in sheep fetuses exposed to a chronic reduced supply of oxygen and nutrients. In studies by Rosen et al as well as Greene et al, changes in the ST segment and shape of the T wave during acute hypoxia were described jointly with a drop in the amount of glycogen and ATP in the myocardium and a rise of potassium and lactate in the plasma [21,22]. An inverse relationship was observed between T/QRS values and the pH of umbilical cord blood sampled during labor [22].…”

Section: Discussionmentioning

confidence: 99%

Fetal Heart Rate Monitoring Using Maternal Abdominal Surface Electrodes in Third Trimester: Can We Obtain Additional Information Other than CTG Trace?

et al. 2016

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Cardiotocography (CTG) is the most widely used method of monitoring fetal heart rate despite its low specificity for fetal acidosis and poor perinatal outcome [1]. It is derived from simple auscultation of the fetal heart, but currently Doppler ultrasound CTG is used for monitoring. Fetal electrocardiography has a greater potential for detecting impairment of fetal circulation; however, it is technically more difficult to perform than CTG.Methods of monitoring fetal well-being, both in the antepartum period and during labor, are constantly developed as they assist in identifying fetal hypoxia and reducing perinatal mortality and morbidity. From the first attempts of monitoring fetal heart rate and registering electrical activity of the fetal heart, researchers sought out a precise description of intrauterine fetal condition and an accurate assessment of the risk of fetal hypoxia. AbstractBackground. Cardiotocography (CTG) is the most widely used procedure despite its low specificity for fetal acidosis and poor perinatal outcome. Fetal electrocardiography (fECG) with transabdominal electrodes is a new, non--invasive and promising method with greater potential for detecting impairment of fetal circulation. This study is the first that attempts to assess the usefulness of fECG in comparison to CTG during antepartum period. Objectives. To determine if a single fECG examination along with CTG tracing and Doppler flow measurement in the fetal vessels has any additional clinical value in normal and intrauterine growth restricted (IUGR) fetuses. Material and Methods. The study included 93 pregnancies with IUGR, 37 pregnancies with IUGR and brain sparing effect, and 324 healthy pregnant women. The T/QRS ratio, cerebro-placental ratio (CRP), and CTG tracings were analyzed. One-way analysis of variance and Spearman's rank correlation coefficient were applied. The relationship between results of the T/QRS ratio and CTG examination among the study groups was analyzed. Results. The highest average mean value of the T/QRS ratio was recorded in the IUGR group with a normal CPR and a pathologic CTG (0.235 ± 0.014). The highest average maximum values were observed in the groups of IUGR pregnancies with a reduced CPR with normal (0.309 ± 0.100), suspicious (0.330 ± 0.102) and pathologic (0.319 ± 0.056) CTGs. Analysis of variance revealed differences between study groups regarding maximum values and the difference between maximum and minimal values of T/QRS. Correlations between groups were insignificant. Conclusions. Higher values of T/QRS ratio in IUGR pregnancies with normal and reduced CPR than in control group regardless of the result of CTG examination may indicate minimal worsening of intrauterine fetal well-being in growth retarded fetuses. No relationship between fECG examination and CTG tracings suggests that a single fECG does not provide any additional clinically significant information determining the condition of the fetus; however, further studies are required (Adv Clin Exp Med 2016, 25, 2, 309-316).

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“…The fHR variability provides physicians with information on the ability of the fetus to adapt to temporal oxygen deficiency and increments in the intra-uterine pressure. Moreover, the temporal and morphological parameters of the fECG provide additional information on fetal growth and its physiological condition [1].…”

Section: Introductionmentioning

confidence: 99%

Artifact reduction in maternal abdominal ECG recordings for fetal ECG estimation

Vullings

Peters

Mischi

et al. 2007

2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Abstract-Monitoring the fetal electrocardiogram (fECG) is currently one of the most promising methods to assess fetal health. However, the main problem associated with this method is that the signals recorded from the maternal abdomen are affected by noise and interferences: the maternal electrocardiogram (mECG) being the dominant interference. In this paper a mECG removal technique is described, which is based on dynamic segmentation of the mECG and subsequent linear prediction of the mECG segments. Moreover, as the linear prediction is significantly affected by artifacts, a signal validation technique is presented to suppress the effect of artifacts on the mECG prediction. The performance of the presented technique is evaluated by comparison to the performance of three other mECG removal techniques: the presented technique outperforms the other techniques for all recordings.

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Changes in the ST waveform of the fetal lamb electrocardiogram with hypoxemia

Cited by 97 publications

References 17 publications

Heart rate variability and electrocardiogram changes in the fetal lamb during hypoxia and beta-adrenoceptor stimulation

Heart rate variability and electrocardiogram changes in the fetal lamb during hypoxia and beta-adrenoceptor stimulation

Fetal Heart Rate Monitoring Using Maternal Abdominal Surface Electrodes in Third Trimester: Can We Obtain Additional Information Other than CTG Trace?

Artifact reduction in maternal abdominal ECG recordings for fetal ECG estimation

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