Changes in the societal burden caused by sleep apnoea in Finland from 1996 to 2018: A national registry study

Mattila, Tiina; Hasala, Hannele; Kreivi, Hanna-Riikka; Avellan-Hietanen, Heidi; Bachour, Adel; Herse, Fredrik; Leskelä, Riikka‐Leena; Toppila‐Salmi, Sanna; Erhola, Marina; Haahtela, Tari; Vasankari, Tuula

doi:10.1016/j.lanepe.2022.100338

Cited by 17 publications

(12 citation statements)

References 23 publications

(53 reference statements)

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“…analysed how the health and economic burden associated with sleep apnoea evolved over the time period from 1996 to 2018. 4 The number of sleep apnoea patients in secondary health care increased more than seven-fold during the study period, from 8600 to 61,000. A probable reason is the increased awareness thanks to the National Programme for Sleep Apnoea implemented by the Finnish Ministry of Social Affairs and Health from 2002 to 2010.…”

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confidence: 94%

“…thus demonstrate how better awareness and knowledge of sleep apnoea, both among the public and healthcare workers, can effectively optimize the uptake of healthcare services and ultimately lead to better outcomes, both for the patient and the society. 4 …”

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confidence: 99%

“…The growing number of healthcare visits due to sleep apnoea led to an even more dramatic increase in the related absences from work, from 1100 absence days in 1996 to 46,000 in 2018. 4 A narrow perspective focusing on this number alone could easily lead to a misinterpretation of the situation as “health versus economy” - an argument that was also often heard during the COVID-19 pandemic. 6 Taking into account the entire societal context however changes the picture.…”

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confidence: 99%

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Knowledge is the key to prevention: Managing the silent epidemic of sleep apnoea

Estill

2022

The Lancet Regional Health - Europe

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confidence: 94%

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confidence: 99%

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confidence: 99%

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Knowledge is the key to prevention: Managing the silent epidemic of sleep apnoea

Estill

2022

The Lancet Regional Health - Europe

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“…The increasing evidence of negative health consequences (Jose et al, 2005; Luyster et al, 2014; Zinchuk et al, 2018) and economic burden (AASM, 2016; Benjafield et al, 2019; Hillman et al, 2018; Mattila et al, 2022) originating from sleep‐disordered breathing (SDB), including obstructive sleep apnea (OSA), is globally acknowledged. This epidemiological pressure has set the need for cost‐effective and patient‐centric technological solutions to be adopted into practices of diagnostics and therapeutics of SDB (Arnardottir et al, 2022; Cooksey & Balachandran, 2016).…”

Section: Introductionmentioning

confidence: 99%

Self‐applied somnography: technical feasibility of electroencephalography and electro‐oculography signal characteristics in sleep staging of suspected sleep‐disordered adults

Rusanen,

Korkalainen,

Gretarsdottir

et al. 2023

Journal of Sleep Research

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SummarySleep recordings are increasingly being conducted in patients’ homes where patients apply the sensors themselves according to instructions. However, certain sensor types such as cup electrodes used in conventional polysomnography are unfeasible for self‐application. To overcome this, self‐applied forehead montages with electroencephalography and electro‐oculography sensors have been developed. We evaluated the technical feasibility of a self‐applied electrode set from Nox Medical (Reykjavik, Iceland) through home sleep recordings of healthy and suspected sleep‐disordered adults (n = 174) in the context of sleep staging. Subjects slept with a double setup of conventional type II polysomnography sensors and self‐applied forehead sensors. We found that the self‐applied electroencephalography and electro‐oculography electrodes had acceptable impedance levels but were more prone to losing proper skin–electrode contact than the conventional cup electrodes. Moreover, the forehead electroencephalography signals recorded using the self‐applied electrodes expressed lower amplitudes (difference 25.3%–43.9%, p < 0.001) and less absolute power (at 1–40 Hz, p < 0.001) than the polysomnography electroencephalography signals in all sleep stages. However, the signals recorded with the self‐applied electroencephalography electrodes expressed more relative power (p < 0.001) at very low frequencies (0.3–1.0 Hz) in all sleep stages. The electro‐oculography signals recorded with the self‐applied electrodes expressed comparable characteristics with standard electro‐oculography. In conclusion, the results support the technical feasibility of the self‐applied electroencephalography and electro‐oculography for sleep staging in home sleep recordings, after adjustment for amplitude differences, especially for scoring Stage N3 sleep.

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“…The consequences of insomnia, such as depression and impaired work performance and decision-making, are substantial and lead to overall poor quality of life. Therefore, sleep disorders significantly impair social and occupational function, thereby increasing socioeconomic burden [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Therapeutics for Treating Sleep Disorders: New Perspectives on Maydis stigma

Kim

Mabunga

Kim

et al. 2022

IJMS

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Sleep is a restorative period that plays a crucial role in the physiological functioning of the body, including that of the immune system, memory processing, and cognition. Sleep disturbances can be caused by various physical, mental, and social problems. Recently, there has been growing interest in sleep. Maydis stigma (MS, corn silk) is a female maize flower that is traditionally used as a medicinal plant to treat many diseases, including hypertension, edema, and diabetes. It is also used as a functional food in tea and other supplements. β-Sitosterol (BS) is a phytosterol and a natural micronutrient in higher plants, and it has a similar structure to cholesterol. It is a major component of MS and has anti-inflammatory, antidepressive, and sedative effects. However, the potential effects of MS on sleep regulation remain unclear. Here, we investigated the effects of MS on sleep in mice. The effects of MS on sleep induction were determined using pentobarbital-induced sleep and caffeine-induced sleep disruption mouse models. MS extracts decreased sleep latency and increased sleep duration in both the pentobarbital-induced sleep induction and caffeine-induced sleep disruption models compared to the positive control, valerian root extract. The butanol fraction of MS extracts decreased sleep latency time and increased sleep duration. In addition, β-sitosterol enhances sleep latency and sleep duration. Both MS extract and β-sitosterol increased alpha activity in the EEG analysis. We measured the mRNA expression of melatonin receptors 1 and 2 (MT1/2) using qRT-PCR. The mRNA expression of melatonin receptors 1 and 2 was increased by MS extract and β-sitosterol treatment in rat primary cultured neurons and the brain. In addition, MS extract increased the expression of clock genes including per1/2, cry1/2, and Bmal1 in the brain. MS extract and β-sitosterol increased the phosphorylation of ERK1/2 and αCaMKII. Our results demonstrate for the first time that MS has a sleep-promoting effect via melatonin receptor expression, which may provide new scientific evidence for its use as a potential therapeutic agent for the treatment and prevention of sleep disturbance.

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Changes in the societal burden caused by sleep apnoea in Finland from 1996 to 2018: A national registry study

Cited by 17 publications

References 23 publications

Knowledge is the key to prevention: Managing the silent epidemic of sleep apnoea

Knowledge is the key to prevention: Managing the silent epidemic of sleep apnoea

Self‐applied somnography: technical feasibility of electroencephalography and electro‐oculography signal characteristics in sleep staging of suspected sleep‐disordered adults

Novel Therapeutics for Treating Sleep Disorders: New Perspectives on Maydis stigma

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