Changes in the Serum Lipids and Apolipoproteins in the First Four Weeks of Life

Lane, Daniel; McConathy, Walter J.

doi:10.1203/00006450-198604000-00011

Cited by 60 publications

(34 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These data strongly support the lack of correlation between the levels of LCAT activity and apo-Al concentration in newborn infants. Previous studies have shown that cord plasma LCAT activity and apo-A, levels in full-term infants are much lower than those in adults (10,(13)(14)(15)(16). Inasmuch as apo-A, is the essential cofactor in the activation of LCAT it was hypothesized that the reduced levels of the former might account for the low levels of the latter (2).…”

Section: Resultsmentioning

confidence: 99%

“…Several investigators focused their attention on apo-Al, which is the essential cofactor of LCAT activity and the principal apolipoprotein of plasma HDL (1,2). Serum apo-Al levels, like LCAT activities, were found to be lower at birth than in adults (10,(13)(14)(15)(16). However, if the reduced enzyme activity is due to low levels of its cofactor remains unclear.…”

mentioning

confidence: 99%

“…Indeed, LCAT activity was found to be lower at birth than in adults (9)(10)(11)(12). Therefore, attempts to understand the mechanism(~) involved in lipid clearing and particularly the regulatory factors of LCAT activity, have been made (10,(13)(14)(15)(16). Several investigators focused their attention on apo-Al, which is the essential cofactor of LCAT activity and the principal apolipoprotein of plasma HDL (1,2).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Low Levels of Apolipoprotein A1 Are Not Contributors to the Low Lecithin-Cholesterol Acyl Transferase Activity in Premature Newborn Infants

et al. 1988

View full text Add to dashboard Cite

ABSTRACT. Umbilical cord sera were obtained from three groups of newborn infants; group I ((n = 8) and group I1 (n = 12) weighed less than 1500 g and between 1500 and 2500 g, respectively. Group 111 (n = 16) was full term and weighed more than 2500 g. Lecithin-cholesterol acyl transferase activities, determined as the rates of esterification of [3Hjcholesterol, were 0.13 f 0.01,0.17 f 0.01, and 0.26 f 0.01 (mean SEM) nmol/h/ml for groups I, 11, and 111, respectively. The adult value (n = 8) was 0.96 f 0.01 nmol/h/ml. The respective apolipoprotein A1 (apo-A,) levels were 52 2 6, 59 f 4, and 67 f 4 (mean f SEM) mg/ dl. Serum level of apo-Al in adults was 137 f 6 mg/dl. Plasma high-density lipoprotein cholesterol levels increased with gestational age. However, in newborn infants, high-density lipoprotein apo-lipoprotein B, total cholesterol, and triglyceride levels, were significantly lower than in adults. These data indicate that serum levels of lecithincholesterol acyl transferase activity significantly (p < 0.01) increase whereas the levels of apo-A, do not significantly change with the gestational age. Also, in full-term newborns, lecithin-cholesterol acyl transferase activity is only 27'70, whereas apo-A1 levels are 49% of adult values. Therefore, lower levels of apo-A1 do not account for the significantly lower activity of lecithin-cholesterol acyl transfierase in preterm as compared to full-term newborn infants. (Pediatr Res 24: 191-193, 1988) Abbreviations LCAT, lecithin-cholesterol acyl transferase Apo-A,, apolipoprotein Al HDL, high-density lipoprotein Apo-El, apolipoprotein B LCAT is an enzyme that converts plasma lecithin and unesterified cholesterol to lysolecithin and cholesteryl ester, and therefore, it plays a key role in the metabolism of phospholipids (1, 2). The latter, as one of the components of fat emulsions, is commonly administered to low birth weight premature infants, who are maintained on total parenteral nutrition. In these new-

show abstract

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Low Levels of Apolipoprotein A1 Are Not Contributors to the Low Lecithin-Cholesterol Acyl Transferase Activity in Premature Newborn Infants

et al. 1988

View full text Add to dashboard Cite

show abstract

“…The ratio measurements are obtained from the one dried blood spot extract so that possible errors in quantitation of the individual apolipoproteins ADO BIA-I TC TG HDL-C LDL-C (12,13). Greater variabilities in the dried blood spot assays for apo B and apo A-I measurements during first few days of life would also be attributable to the weak correlations in apo B and apo A-I levels at these two times.…”

Section: Discussionmentioning

confidence: 99%

Apolipoproteins A-I and B and the B/A-I Ratio in the First Year of Life

1991

View full text Add to dashboard Cite

ABSTRACT. To investigate early detection of young families with inherited dyslipidemia, we assessed changes in circulating apolipoprotein (apo) B and A-I levels and the apo B/A-I ratio during the 1st year of life and their relations to parental values. After measuring initial dried blood spot capillary blood levels in 919 babies when aged 4.25 f 0.98 d (mean 2 SD), we recalled at a mean age of 8.5 f 2.3 mo those with levels in one or more of the following categories: the top 5% of apo B values (group I), the top 5% of apo B/A-I ratios (group 2), the bottom 5% of apo A-I values (group 3), and a group of 18 infants (group 4) who were not in any of the above three categories. We thus obtained serum lipid measurements in 51 infants and their parents. Two of the 13 group 1 infants had persistent hyperapo B at 8.5 mo; there was an inverse relationship between apo B and apo A-I levels in this group ( p < 0.001). Two of 11 babies in group 2 had lipid profiles consistent with familial hypercholesterolemia. However, none of the infants in group 3 had evidence at 8.5 mo of abnormal apo A-I or HDL levels, nor did their parents. For groups 1, 2, and 3, there was at 8.5 mo a regression of apo B and A-I toward mean levels for the "normal" 18 babies of group 4. In contrast, the high apo B/A-I ratios in group 2 remained high ( p < 0.01) and showed evidence of tracking. Correlations between birth weight and apo B (positive) and apo A-I (negative) that were found previously at 1 wk were still evident at 8.5 mo. Thus, individual apo B/A-I ratio measurements during the'lst week of life are predictive of levels at 8.5 mo, and this finding may facilitate familial hypercholesterolemia detection. Persistence of significant correlations between birth weight and apolipoprotein levels suggests an ongoing relationship between birth weight and subsequent lipid metabolism. (Pediatr Res 30: 544-549, 1991) Abbreviations apo A-I, apolipoprotein A-I apo B, apolipoprotein B apo(a), apolipoprotein(a)In a recent study we measured apo A-I, the principal protein moiety of the antiatherogenic HDL cholesterol, and apo B, the carrier protein for the atherogenic LDL cholesterol, in 919 consecutively born neonates of birth weights 2 kg or greater when they were 2 to 5 d old (1). We wished to assess the variables affecting both of these apolipoproteins in the neonatal period Supported by the National Heart Foundation of Australia. 5and to explore the hypothesis that the ratio of apo B to A-I when measured in dried blood spots obtained during routine neonatal screening programs could identify families with genetically determined dyslipidemias associated with increased cardiovascular risk. Levels of these apolipoproteins may be better predictors of coronary risk than HDL and LDL cholesterol (2-4). Our ultimate aim is to facilitate family-based coronary prevention directed to young parents with dominantly inherited dyslipidemia in the expectation that this would also benefit the children themselves when older (5). Our studies showed that birth weight, day ...

show abstract

“…However, because the human lipid transport system has been shown to undergo several changes from its fetal to adult form (2,(12)(13)(14)(15), the purpose of this study was to provide information on the concentration and composition of these two major HDL families in plasma of normal, prepubertal children of both sexes and to compare them with those of adults.…”

mentioning

confidence: 99%