Changes in the retrobulbar arterial circulation after decrease of the elevated intraocular pressure in men and women with primary open angle glaucoma

Abstract

There was a difference of the retrobulbar arterial circulation between women and men with primary open angle glaucoma after decrease of the elevated intraocular pressure.The role of vascular factors in the supply of the optic disc neuroretinal rim is important.

Aqueous humor proteomic analysis of acute angle-closure glaucoma with visual field loss

“…Regarding ocular hemodynamics, increased IOP can lead to hemodynamic changes in the ocular blood vessels that supply the optic nerve (7). Alterations may cause ischemic death of RGCs by reducing the supply of oxygen and nutrients (34,35).…”

“…Taken together, we integrated the results of functional analysis and attempted to infer the connection between them. Other studies have reported that elevated IOP during AACG altered the function of blood vessels in the eye, causing ischemia, while other activities, such as neovascularization and vasoconstriction, also contributed to ischemia (3,7,34,35). Focal ischemia might induce an inflammatory response, and then immune cells might produce harmful ROS.…”

“…Glaucomatous optic nerve damage occurs due to RGC death (6). To date, many studies have pointed out that ocular hemodynamic changes and vascular pathological changes tend to cause optic nerve ischemic reperfusion injury, eventually resulting in RGC death (7,8). Some molecules injure RGCs in various ways, one being nitric oxide (NO), which induces apoptosis and aggravates retinal damage.…”

Effects of Sex Hormones on Ocular Blood Flow and Intraocular Pressure in Primary Open-angle Glaucoma: A Review

“…12 In another study, in response to therapeutically reduced IOP, peak systolic velocity (PSV) increased in women in the central retinal artery (CRA) and decreased in the ophthalmic artery (OA) and posterior ciliary arteries (PCAs). 13 In this same study, PSV and end diastolic velocity (EDV) decreased in all three vessels in men. These findings are not without controversy.…”

The Role of Plasma Lipid Profile in Patients with Type A Behavior Pattern with POAG

“…Moreover, Rader et al [12] and Kerr et al [13] have been able to show the presence in the retinal peripapillary vessels of patients with systemic arterial hypertension a reduction in flow consequent on an arteriolar spasm probably due to vaso-constrictive hypersensitivity. There would therefore seem to be, both in hypertensive and hypotensive peaks, with a different pathogenetic mechanism, a reduction in retinal perfusion.…”