Changes in the Rate of Lipid Peroxidation in Plasma and Selected Blood Antioxidants before and during Pregnancy in Ewes

Erişir, Mine; Benzer, Fulya; Kandemir, Fatih Mehmet

doi:10.2754/avb200978020237

Cited by 24 publications

(28 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Erisir et al (2009), similar to Oztabak et al (2005), did not find any significant differences between plasma concentrations of lipid peroxidation markers (TBARS, MDA) in pregnant and non-pregnant ewes. In contrast, Joshi et al (2013) found that serum biomarkers of oxidative stress were significantly higher in pregnant buffaloes than in non-pregnant animals.…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Assessment of lipid and protein peroxidation markers in non-pregnant and pregnant female dogs

Szczubiał¹,

Kankofer²,

Dąbrowski³

et al. 2015

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

The aim of the study was to investigate oxidative stress during normal pregnancy in female dogs based on an evaluation of plasma markers for lipid and protein peroxidation. Twenty clinically healthy female dogs (10 non-pregnant and 10 pregnant) were used in the study. Blood samples from the pregnant animals were collected at 19-21, 38-40, and 56-58 days of pregnancy. Blood samples from non-pregnant female dogs were obtained between 20 and 35 days after ineffective breeding. As indicators of oxidative stress, we measured the following using spectrophotometric and spectrofluorimetric methods: thiobarbituric acid reactive substances (TBARS), radical cations of N,N, diethylpara-phenylene diamine (RC-DEPPD), sulfhydryl groups (SH groups), bityrosine and formylkynurenine. The mean plasma TBARS concentration in the pregnant dogs (0.486 ± 0.071 -0.581 ± 0.191 μmol/g protein) was significantly higher (p<0.05) than that found in the non-pregnant animals (0.274 ± 0.111 μmol/g protein). A marked, although not significant, decrease in SH group content, as well as an increase in bityrosine and formylkynurenine concentration were concurrently observed in the pregnant dogs. No significant differences were found in terms of the studied markers in the pregnant animals when comparing the values obtained during the investigated periods of pregnancy, although there was a progressive decrease in TBARS concentration and a progressive increase in RC-DEPPD, bityrosine and formylkynurenine contents. Our findings suggest that normal pregnancy in female dogs is associated with oxidative stress. Further studies are necessary to establish the physiological ranges of antioxidative/oxidative profiles in pregnant dogs and to explain if and how the intensity of oxidative stress might contribute to the risk of the complications of pregnancy.

show abstract

Section: Discussionsupporting

confidence: 87%

“…Another cause of deficiency of these antioxidants during pregnancy could be placental transfer. Significant changes in the antioxidant enzyme activities have also been observed in pregnant females (Watson et al 1997, Djordjevic et al 2004, Jauniaux et al 2005, Oztabak et al 2005, Erisir et al 2009, Hung et al 2010.…”

Section: Discussionmentioning

confidence: 97%

Assessment of lipid and protein peroxidation markers in non-pregnant and pregnant female dogs

Szczubiał¹,

Kankofer²,

Dąbrowski³

et al. 2015

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…These observations suggest that up to this point the organism of the sheep was free of oxidative stress, and thus there was homeostasis in the redox status of the organism. Erisir et al (13) showed a predisposition to oxidative stress in pregnant sheep as early as the second to third months of pregnancy. The results of the study also show that the greatest changes in redox status indicators indicating increasing oxidative stress (reductions in FRAP, LOOH, and SOD, and increases in MDA and CAT) were noted 24 h before lambing.…”

Section: Discussionmentioning

confidence: 99%

“…Pregnancy is regarded as a physiological state of the organism, and changes in biochemical status and frequently observed complications, such as gestational diabetes, pre-eclampsia, eclampsia, abortions, premature births, or hypertension, are identified as the effect of lipid peroxidation processes which escalate during pregnancy (13,29).…”

Section: Introductionmentioning

confidence: 99%

Redox status in the blood of ewes in the perinatal period and during lactation

Ognik

Patkowski

Gruszecki

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

View full text Add to dashboard Cite

The aim of the study was to determine the effect of the perinatal period on redox status indicators in the blood of ewes before and after lambing and during lactation. The study was performed on 12 ewes of the synthetic SCP line. Blood for testing of redox parameters was collected seven times: before pregnancy, 1.5 months and 24 h before lambing, 2 and 24 h after lambing, and in the fourth and eighth weeks of lactation. The following blood indices were determined by spectrophotometry: lipid peroxides, malondialdehyde, superoxide dismutase, catalase, plasma total antioxidant capacity, uric acid, urea, bilirubin, and creatinine. The tests showed that during the perinatal period reactions are generated which lead to oxidative stress. Oxidative stress in pregnant ewes was found to increase during the period before lambing and may persist even up to weeks 4-8 of lactation.

show abstract

“…In the periparturient period the female is particularly exposed to disturbance of energy balance as well as disturbance of balance between the production of reactive oxygen species and the optimization of mechanisms protecting against the results of oxidative stress (Górecka et al2002;Toescu et al 2002;Wender-Ożegowska et al 2004;Upadhyaya et al 2005, Erisir et al 2009). …”

mentioning

confidence: 99%

Purine Turnover Metabolites and Selected Antioxidants in Blood of Goats during the Periparturient Period

et al. 2010

View full text Add to dashboard Cite

The aim of this study was to examine the relationships between the erythrocyte concentrations of ATP, ADP, AMP, NAD + , NADP + and adenylate energy charge (AEC) and their metabolites: inosine (Ino), hypoxanthine (Hyp), uric acid (UA), selected blood antioxidants: superoxide dismutase (SOD), glutathione reductase (GR) of goats during the periparturient period.The study was conducted on 12 clinically healthy pregnant goats (Capra hircus) -75% genotype of the Polish noble white aged between 2-3 years. Blood was taken from the external jugular vein early in the morning before feeding and obtained twice (4 weeks and 1 week) before delivery and twice (2 and 3 weeks) after delivery.The ATP concentration did not change significantly. One week before delivery ADP, AMP and Ino concentrations were significantly higher and AEC value significantly lower compared to values in the third week after delivery (p ≤ 0.02, p ≤ 0.05, p ≤ 0.03 and p ≤ 0.01, respectively). One week before and two weeks after delivery we observed a significant increase in SOD and GR activities and an increase in NAD + and NADP + concentrations but a significant decrease in Hyp and UA concentrations. Constant ATP concentration and the changes in the dynamics and tendency of Hyp and UA concentrations show that in the periparturient period in goats, purine metabolism undergoes adaptive changes. The balance between resynthetic processes and adenine nucleotide degradation is retained in order to level the oxygen and energy lacks. The results of our study show that the maintenance of prooxidative homeostasis in goats of peripartal period depends mainly on enzymatic mechanisms.

show abstract

Changes in the Rate of Lipid Peroxidation in Plasma and Selected Blood Antioxidants before and during Pregnancy in Ewes

Cited by 24 publications

References 30 publications

Assessment of lipid and protein peroxidation markers in non-pregnant and pregnant female dogs

Assessment of lipid and protein peroxidation markers in non-pregnant and pregnant female dogs

Redox status in the blood of ewes in the perinatal period and during lactation

Purine Turnover Metabolites and Selected Antioxidants in Blood of Goats during the Periparturient Period

Contact Info

Product

Resources

About