Changes in the proportions of an active pharmaceutical through cocrystals

Abstract

In this study, the modulation of amounts sulfathiazolium cations in different 2,6-pyridinedicarboxylates is demonstrated. An uncommon monoionic sulfathiazolium zinc 2,6-pyridinedicarboxylate (1:1 electrolyte) complex was characterized. Conventional sulfathiazolium zinc-bis-2,6-pyridinedicarboxylate dianionic complexes (2:1 electrolyte) were formed when hydroxyaromatic compounds such as 1,3-dihydroxybenzene or 3-nitrophenol were used as guest components. Thus, with the aid of the hydroxyaromatic molecules the zinc-bis-2,6-pyridinedicarboxylate complexes were stabilized with the relatively large sized sulfathiazolium cations. It was a consequence of domain expansion by the phenolic compounds. Sandwiched aromatic guests between the 2,6-pyridinedicarboxylates provided appropriate packing to accommodate the two large cations in the self-assemblies, which helped to modulate the amounts of sulfathiazole in different formulations. Antibacterial activities with E. coli DH5α have shown that the salt and the complexes have lower g/ml antibacterial activity than the parent drug.

Arrangements of fluorophores in the salts of imidazole tethered anthracene derivatives with pyridinedicarboxylic acids influencing photoluminescence

“…The literature suggests that such synthons are useful in generating extended assemblies and contribute to molecular recognition. 32 These synthons were connected to the N + -H bond of the imidazolium cationic part. One oxygen atom from each of the other carboxylate groups of two independent 35pdc ions acted as bridging atoms to two N + -H of the two independent di-cations.…”

Polymorphs, ionic cocrystal and inclusion complex of N-amino-1,8-naphthalimide

“…38 The stacking effect and the concomitant hydrogen bond donor/acceptor behavior of naphthalimide derivatives make them attractive to generate polymorphs. [39][40][41] On the other hand, the aggregates of naphthalimide derivatives 42,43 and metal complexes 44 provide interesting properties. The reported crystal structure of 2-amino-1Hbenzo[de]isoquinoline-1,3(2H)-dione, alternatively known as N-amino-1,8-naphthalimide (L), has two symmetry nonequivalent molecules present in the unit cell 45 and it is interesting that such a system may have a symmetric counterpart, as observed in limited examples in the literature in other systems.…”