Changes in the prevalence of HBV infection in pregnant women in Turkey between 1995 and 2015: a 20-year evaluation

Furuncuoglu, Yavuz; Bolukbas, Fusun F.; Bolukbas, Cengiz; Torun, Perihan; Öztürk, Recep

doi:10.1136/postgradmedj-2015-133876

Cited by 15 publications

(7 citation statements)

References 18 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Regarding the year of publication, recently published studies reported significantly lower pooled prevalence estimate of 2.252% compared to earlier studies with pooled prevalence of 6.386% ( P < 0.001). The decrease in HBsAg positivity rate among pregnant women on ANC observed in recent publications in our meta-analysis has also been reported in Turkey from a period of 2013 to 2016 [ 87 ] and from 1995 to 2015 [ 88 ]. This could be probably attributed to improved awareness of both viruses [ 68 ] as well as introduction of national immunization programs.…”

Section: Discussionsupporting

confidence: 85%

Sero-prevalence of human immunodeficiency virus–hepatitis B virus (HIV–HBV) co-infection among pregnant women attending antenatal care (ANC) in sub-Saharan Africa (SSA) and the associated risk factors: a systematic review and meta-analysis

Kafeero

Ndagire

Ocama

et al. 2020

Virol J

View full text Add to dashboard Cite

Background There is plenitude of information on HIV infection among pregnant mothers attending antenatal care (ANC) in sub-Saharan Africa. However, the epidemiology of HBV–HIV co-infections in the same cohort is not clear despite the common route of transmission of both viruses. The aim of our study was to synthesize data on the prevalence of HBV–HIV co-infection among pregnant women attending ANC in Sub-Saharan Africa to assist in the design of public health interventions to mitigate the challenge. Methods The study was done in tandem with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) standards and the Cochran’s Q test, I2 statistics for heterogeneity and the prevalence were calculated using commercially available software called MedCalcs (https://www.medcalc.org). A random effect model was used to pool the prevalence since all the heterogeneities were high (≥ 78%) and Phet < 0.05 indicated significant heterogeneities. The risk factors and risk differences for HBV–HIV co-infection were analyzed. Any likely sources of heterogeneity were analyzed through sensitivity analysis, meta-regression and sub-group analysis. All analyses were done at 95% level of significance and a P < 0.05 was considered significant. Results The overall pooled prevalence of HBV–HIV co-infection among pregnant mothers in sub-Saharan Africa was low 3.302% (95%CI = 2.285 to 4.4498%) with heterogeneities (I2) of 97.59% (P > 0.0001). Within regional sub group meta-analyses, West Africa had significantly higher prevalence of 5.155% (95% = 2.671 to 8.392%) with heterogeneity (I2) of 92.25% (P < 0.0001) than any other region (P < 0.001). Articles published from 2004–2010 had significantly higher prevalence of 6.356% (95% = 3.611 to 9.811%) with heterogeneity (I2) 91.15% (P < 0.0001) compared to those published from 2011 to 2019 (P < 0.001). The HIV positive cohort had significantly higher prevalence of HBV–HIV co-infection of 8.312% (95% CI = 5.806 to 11.22%) with heterogeneity (I2)94.90% (P < 0.0001) than the mothers sampled from the general population with a prevalence of 2.152% (95% CI = 1.358 to 3.125%) (P < 0.001). The overall and sub group analyses had high heterogeneities (I2 > 89%, P < 0.0001) but was reduced for South Africa (I2) = 78.4% (P = 0.0314). Age, marital status and employment were independent factors significantly associated with risk of HBV–HIV co-infection (P < 0.001) but not extent of gravidity and education level (P > 0.05). After meta-regression for year of publication and sample size for HBsAg positivity, the results were not significantly associated with HBV pooled prevalence for sample size (P = 0.146) and year of publication (P = 0.560). Following sensitivity analysis, the HBsAg pooled prevalence slightly increased to 3.429% (95% CI = 2.459 to 4.554%) with heterogeneity I2 = 96.59% (95% CI = 95.93 to 97.14%), P < 0.0001 Conclusion There is an urgent need for routine HBV screening among HIV positive pregnant mothers attending antenatal care in sub-Saharan Africa to establish the extent of HBV–HIV co-infection in this cohort. Future studies need to investigate the putative risk factors for HBV–HIV co-infection and prioritize plausible control strategies.

show abstract

Section: Discussionsupporting

confidence: 85%

Sero-prevalence of human immunodeficiency virus–hepatitis B virus (HIV–HBV) co-infection among pregnant women attending antenatal care (ANC) in sub-Saharan Africa (SSA) and the associated risk factors: a systematic review and meta-analysis

Kafeero

Ndagire

Ocama

et al. 2020

Virol J

View full text Add to dashboard Cite

show abstract

“…Furuncuoğlu et al (6) support the data of Şahin et al (5) in the study of hepatitis B seroprevalance of 7605 pregnant women in three different periods of 1995-2015. HBsAg positivity was found to decrease from 2.6% to 0.8% between 1995 and 2001, while anti-HBs positivity increased from 9.5% to 17.5%.…”

supporting

confidence: 59%

Epidemiology of Viral Hepatitis Changes in Our Country

Baykam¹,

Güner²

2018

vhd

View full text Add to dashboard Cite

“…From the same cohort of that study, we analyzed pregnant women in a separate study and found it to be 1.5% for HBsAg and 11.5% for anti-HBs. Totally, 7605 pregnant women were evaluated for the period of 20 years, from 1995 to 2015 (25). It can be seen that the HBV prevalence is lower in blood donors, probably because those who are aware of their HBV status do not apply for blood donation.…”

Section: Discussionmentioning

confidence: 99%

Seroepidemiology of Hepatitis B Virus Infection in İstanbul: A 20-year Survey

Furuncuoglu¹,

Saglam²,

Bolukbas³

et al. 2016

vhd

View full text Add to dashboard Cite

ÖZObjective: Turkey is an intermediate endemic country for hepatitis B virus (HBV) infection, with the prevalence rates showing regional differences. The aim of this study was to determine the recent prevalence of HBV infection among adults in İstanbul and to evaluate the impact of national vaccination program that started in 1998. Materials and Methods: Data of three healthcare centers from 3 different districts in İstanbul between 1995 and 2015 were obtained. HBV status of the participants was evaluated according to their hepatitis B surface antigen (HBsAg) and anti-HBs results. The change in HBV prevalence was evaluated by dividing the time included in the study into three periods: 1995-2002, 2003-2009 and 2010-2015. Statistical comparison between groups studied in each period was performed. To evaluate the impact of vaccination, the patients of 15-17 years of age were compared with the rest of the last study group. Results: Totally, 26001 adult patients were included in the study.HBsAg and anti-HBs tested positive in 4.24% and 16.81% of patients, respectively. When the 20 years included in the study were divided into three periods and each studied separately, the positive results for HBsAg decreased from 5.34% to 4.8% and 3.08%, and positive anti-HBs results increased from 14.24% to 15.45% and 19.57%, the difference between the groups being statistically significant (p<0.001). In vaccinated group (n=287), no one tested positive for HBsAg and 30.3% of patients tested positive for antiHBs, being statistically different from the rest of the group (p<0.001). Conclusion:Despite the positive effects of vaccination, chronic HB remains a serious health problem.

show abstract

Changes in the prevalence of HBV infection in pregnant women in Turkey between 1995 and 2015: a 20-year evaluation

Cited by 15 publications

References 18 publications

Sero-prevalence of human immunodeficiency virus–hepatitis B virus (HIV–HBV) co-infection among pregnant women attending antenatal care (ANC) in sub-Saharan Africa (SSA) and the associated risk factors: a systematic review and meta-analysis

Sero-prevalence of human immunodeficiency virus–hepatitis B virus (HIV–HBV) co-infection among pregnant women attending antenatal care (ANC) in sub-Saharan Africa (SSA) and the associated risk factors: a systematic review and meta-analysis

Epidemiology of Viral Hepatitis Changes in Our Country

Seroepidemiology of Hepatitis B Virus Infection in İstanbul: A 20-year Survey

Contact Info

Product

Resources

About