Changes in the peripheral vasculature of various organs in patients with sarcoidosis—Possible role of microangiopathy

Mikami, Riichirō; Sekiguchi, Morie; Ryuzin, Yoshitada; Kobayashi, Fumiko; Hiraga, Y; Shimada, Yasuyuki; Mochizuki, Ichiro; Kobayashi, Toshio; Tamura, Shizuo; Hosoda, Yutaka

doi:10.1007/bf02128138

Cited by 38 publications

(24 citation statements)

References 26 publications

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“…Because of its severity, the thickening differs clearly from that in other cardiomyo pathies. Thickening, either with or without multilayering, has been reported to occur in the basement membranes of myocardial cap illaries in diabetes mellitus [37], myocardial sarcoidosis [38,39] and myxedema [40], and in mice with a genetically transmitted cardio myopathy that is associated with diabetes mellitus (KK mice) [41], In all of these in stances, the affected basement membranes of ten tend to form multiple, concentrically ar ranged layers, which may be individually somewhat thicker than a single normal base ment membrane; however, thickening of basement membranes consisting of a single layer of material also occurs in diabetes melli tus and myxedema [37. 40], None of our patients had these diseases.…”

Section: Basement Membrane Thickeningmentioning

confidence: 99%

Endomyocardial Biopsies in Chronic Chagasic Cardiomyopathy

Milei

Storino²,

Alonso³

et al. 1992

Cardiology

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Mononuclear cellular infiltrates and extensive fibrosis, with or without apical ventricular aneurysms, are the usual morphological findings in chronic chagasic cardiomyopathy. These lesions are thought to be mediated by immune phenomena rather than by continuing parasitic invasion of the heart. In the present report, we correlated clinical, immunohistochemical and ultrastructural findings in 30 endomyocardial biopsies from patients with chronic chagasic cardiomyopathy. In 12 of these biopsies, immunocytochemical techniques were used to identify and count leukocytes (common leukocyte antigen, CLA), T lymphocytes (UCHL-1 antibody) and B lymphocytes (L-26 antibody). The biopsy specimens showed variable degrees of myocardial hypertrophy and mononuclear infiltrates. No tissue forms of trypanosomes were found. The endocardium averaged 24 ± 12.6 µm (mean ± SD) in thickness. The mean myocyte diameter was 20 ± 7.33 µm. The hearts were severely fibrotic containing a mean of 24.1 ± 12.8% of fibrous tissue (range 8.2-49%), mast cells were scarce. Mononuclear cell infiltrates were found in 25 of the 30 biopsies. In 12 biopsies, immunohistochemical studies showed that the majority of the lymphocytes were T lymphocytes and associated with necrotic or degenerating myocytes. 10 of the 12 biopsy samples showed 5 or more CLA-positive mononuclear cells/high power field. In these 10 patients, T and B lymphocytes represented 32 and 13% of the total mononuclear infiltrating cells, respectively. The remaining cells were monocytes and macrophages.

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Section: Basement Membrane Thickeningmentioning

confidence: 99%

Endomyocardial Biopsies in Chronic Chagasic Cardiomyopathy

Milei

Storino²,

Alonso³

et al. 1992

Cardiology

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“…Vracko reported that BLL was frequently observed in the skeletal muscle of patients with diabetes mellitus [6]. Mikami et al found BLL in the myocardium as well as skeletal muscle in patients with sarcoidosis [7]. Few studies have described BLL in the heart muscle of DCM [8].…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural features of the myocardium of children with dilated cardiomyopathy

et al. 1999

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We analyzed the electron-microscopic features of endomyocardial biopsy from pediatric patients with dilated cardiomyopathy (DCM). The specimens examined were taken from the right ventricle of ten patients aged from 2 to 15 years (mean 9.7 years). Biopsy specimens from eight patients with congenital heart disease (tetralogy of Fallot), aged from 3 to 12 (mean 7.3 years), and ten adult patients with DCM, aged from 32 to 60 (mean 45 years), were also examined. Patients considered to have endocardial fibroelastosis, arrhythmogenic right ventricular cardiomyopathy, specific cardiomyopathy, or coronary heart disease were excluded from this study. Specimens from pediatric patients with DCM showed various degrees of ultrastructural abnormalities of myocytes, including myofibrillar fragmentation, mitochondrial abnormalities, and intracellular edema. The ultrastructurally determined contractility failure index based on the severity of myocardial degeneration at the electronmicroscopic level was 4.9 +/- 1.1. This value was significantly higher than that in patients with tetralogy of Fallot (0.9 +/- 0.6, P < 0.001) but was not significantly different from that in adult patients with DCM (6.1 +/- 2.6). The index of pediatric patients with DCM who died within 3 years was high (6.0 +/- 0.8). Basal lamina layering of a capillary (BLL) in the myocardium was revealed in 1 of the 10 (10%) pediatric patients with DCM and in 6 of the 10 (60%) adult patients with DCM (P < 0.05). No BLL was noted in the patients with tetralogy of Fallot. These findings may be related to the pathogenesis of DCM in children and adults.

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“…30) It was reported by Mikami, et al that the electron microscopic study disclosed basal lamina layering (BLL) of the capillaries in the skeletal muscle of sarcoidosis patients. 31) Sekiguchi, et al found BLL in EMB specimens from 77.8% of patients with sarcoidosis. 28) They concluded that sarcoidosis with microangiopathic processes could exist and these were an important element of the disease.…”

Section: Sarcoidosismentioning

confidence: 99%

More than 50 Years after Konno's Development of the Endomyocardial Biopsy

Nishikawa

Sekiguchi²,

Ishibashi‐Ueda

2017

Int. Heart J.

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SummaryThe endomyocardial biopsy (EMB) method was first developed by Japan's Dr. Souji Konno in 1962. Since then, this technique has been used worldwide in clinical cardiology for the recognition and diagnosis of cardiomyopathies, arrhythmias, and other heart conditions. Many studies relating to the EMB have been published at the global level, including a large review by Cooper, et al.,1) wherein a limited selection of Japanese papers were cited despite considerable pioneering work on the EMB having been done in Japan. Following this, the Cardiac Biopsy Conference (CABIC) organization, which was founded in Japan in 1979, conducted a nationwide survey of the English language literature on the EMB. Among the collection of 500 studies compiled, approximately 40 abstracts have been selected by the co-editors in CABIC for further discussion. This report aims to supplement Cooper's work and bring to light other prominent contributions of Japanese researchers on the EMB.(Int Heart J 2017; 58: 840-846)

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Changes in the peripheral vasculature of various organs in patients with sarcoidosis—Possible role of microangiopathy

Cited by 38 publications

References 26 publications

Endomyocardial Biopsies in Chronic Chagasic Cardiomyopathy

Endomyocardial Biopsies in Chronic Chagasic Cardiomyopathy

Ultrastructural features of the myocardium of children with dilated cardiomyopathy

More than 50 Years after Konno's Development of the Endomyocardial Biopsy

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