Changes in the participation and expression of angiotensin II receptor At1 in heart and kidney of rats 6 weeks old with neonatal administration of de dexametasone and hyperbaric oxygen therapy

Abstract

One therapy that has demostrated that it normalize the cardiovascular responses of angiotensin receptor in one experimental model, is the hyperbaric oxygen therapy. It has been described the wide use of dexametasone during the neonatal period of time, having different and controversial responses. Dexametasone has been used commonly due to the improvement in the lung function into the respiratory difficulty syndrome. Some studies reports that the use of steroid during the neonatal period could have some beneficial effects but also it could induce cardiovascular and renal disorder during the development. As it has been described one of the main pathway involved is the renin‐aldosterone‐angiotensin system. Some researchers describe that steroids regulate the angiotensin II receptor and function.Objetivethe main idea is to analize the modification of the expression of angiotensin II receptor in rat with administration neonatal of dexametasone with/without hyperbaric oxygen therapy.Methodologyneonatal rat (2 days) were administrated with dexametasone and were divided in 2 groups one with hyperbaric oxygen therapy and the other without therapy. At the age of 6 weeks the animals were sacrificed, and the expression of the receptor At1 were measured in the heart and the kidney by PCR and inmunohistochemistry.ResultsThe group only with dexametasone showed has major expression of At1 receptor, however the group with dexametasone and hyperbaric oxygen therapy has a reduction in the expression of this receptor.ConclusionThis results could suggest that the hyperbaric oxygen therapy could normalize the expresion in this rats with dexametasone treatment, being beneficial because it could reduce the possibility of one cardiovascular pathology like and infarct.Support or Funding InformationSIP, COFAA, IPNThis abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.