Changes in the lymphocyte count and lymphocyte subsets after splenectomy in human immunodeficiency virus infection

A case-control study was conducted at two institutions to determine whether the absolute CD4 lymphocyte count or the percentage of lymphocytes bearing the CD4 marker (i.e., the CD4 percentage) is a more accurate indicator of underlying immune status in splenectomized patients infected with human immunodeficiency virus (HIV). Each of nine splenectomized HIV-infected cases was matched with six nonsplenectomized HIV-infected controls--three matched for CD4 lymphocyte count and three for CD4 percentage. In analyses including the eight cases with an initial CD4 lymphocyte count of > 200/mm3, controlling for the CD4 count revealed differences between cases and controls in terms of CD4 percentage (range, 10%-41% and 17%-54%, respectively; P < .01) and Centers for Disease Control and Prevention (CDC) clinical stage (P = .06). Controlling for the CD4 percentage revealed a significant difference between cases and controls in terms of CD4 count (range, 396-1,040 and 55-784 cells/mm3, respectively; P < .01) but not CDC clinical stage (P > .7). These data suggest that the numerical relationship between the CD4 lymphocyte count and the CD4 percentage among splenectomized HIV-infected patients with more than 200 CD4 cells/mm3 differs from that among nonsplenectomized patients. The CD4 percentage appears to be a more accurate indicator of the underlying level of immune function in the former group of patients.

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Changes in the lymphocyte count and lymphocyte subsets after splenectomy in human immunodeficiency virus infection

Cited by 6 publications

References 8 publications

Hematologic Complications of Human Immunodeficiency Virus Infection and the Acquired Immunodeficiency Syndrome

Hematologic Complications of Human Immunodeficiency Virus Infection and the Acquired Immunodeficiency Syndrome

Cytomegalovirus retinitis, human immunodeficiency virus antibody positivity and normal T helper cell numbers

Effect of Splenectomy on T Lymphocyte Subsets in Patients Infected with the Human Immunodeficiency Virus

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