Changes in the Levels of Progesterone, Corticosteroids, Estrone, Estradiol-17 β, Luteinizing Hormone, and Prolactin in the Peripheral Plasma of the Ewe During Late Pregnancy and at Parturition

Chamley, W. A.; Buckmaster, Joan M.; Cerini, Mildred; Cumming, I. A.; Goding, J. R.; Obst, JM; Williams, A.E.; Winfield, C.G.

doi:10.1093/biolreprod/9.1.30

Cited by 65 publications

(38 citation statements)

References 20 publications

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“…Concentrations of G in plasma during injections were within the prepartum range between 10 and 20 ng/ml (Chamley et al, 1973). Although variable, Prl concentrations were generally higher (> 100 ng/ml) throughout induced lactation than those observed during the last month of pregnancy.…”

Section: Introductionmentioning

confidence: 82%

“…Although variable, Prl concentrations were generally higher (> 100 ng/ml) throughout induced lactation than those observed during the last month of pregnancy. When milking was initiated, the concentrations were equivalent to those at parturition (100 to 640 ng/ml) (Chamley et al, 1973 ;Kann et al, 1978). This suggests that Prl was not limiting when milking was initiated in ewes induced into lactation.…”

Section: Introductionmentioning

confidence: 99%

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Hormone levels in plasma of ewes induced into lactation

Head¹,

Delouis²,

Fevre³

et al. 1982

Reprod. Nutr. Dévelop.

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Summary. A short-term treatment with estradiol-17(3 and progesterone induced mammary gland growth and lactogenesis in non-pregnant ewes. These events normally occur during the second half of pregnancy. In order to compare the hormonal environment during the treatment to that during pregnancy, the concentrations of total estrogens (TE), progesterone (P 4 ), glucocorticoids (G) and prolactin (Prl) Average pretreatment concentrations of plasma TE and P 4 were 3.1 + 0.8 and 2.1 ± 0.4 ng/ml, respectively ; these increased to 10.2 + 1.3 and 5.6 ± 0.6 ng/ml during the week of the E 2 -/3 and P 4 injections. Peak concentrations occurred on days 7 and 6, respectively, and the plasma levels had returned to pretreatment values by days 18 to 20. Concentrations of G in plasma were higher (13.0 ± 1.0 ng/ml) during E 2 -0 and P 4 injections than during pre-or post-injection (7.4 ± 1.4 and 8.2 ± 0.7 ng/ml, respectively). Plasma Prl showed biphasic two to six-fold increases on days 4 and 7 during E 2 -0 and P 4 injections and thereafter declined to lower average daily concentrations on days 10 to 13. Plasma Prl began to increase, and its average concentration was 579 + 56 ng/ml by days 18 to 20.These results suggest that the amount of the P 4 injections should be increased and that the treatment with E Z -[3 and P Q should last long enough to insure the induction of an endocrine balance which would correspond more accurately to the hormonal events occurring during the second half of pregnancy in the ewe.(1) Florida Agr.

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Section: Introductionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Hormone levels in plasma of ewes induced into lactation

Head¹,

Delouis²,

Fevre³

et al. 1982

Reprod. Nutr. Dévelop.

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“…A distinct increase in peripheral blood concentrations of prolactin has been reported in relation to parturition in large domestic animals such as the cow (Hoffmann et al, 1973;Karg and Schams, 1974), sheep (Chamley et al, 1973;Kann and Denamur, 1974) and goat (Hart, 1972).…”

Section: Introductionmentioning

confidence: 97%

Plasma prolactin, progesterone and oestradiol-17β concentrations around parturition in the pig

Taverne

Willemse

Dieleman

et al. 1979

Animal Reproduction Science

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Taverne, M., Willemse, A.H., Dieleman, S.J. and Bevers, M., 1978/1979. Plasma prolactin, progesterone and oestradiol-17~ concentrations around parturition in the pig. Anim. Reprod. Sci., 1: 257--263.Plasma concentrations of prolactin, progesterone and oestradiol-17~ were measured by radioimmunoassay in samples taken from 2--15 days before until 1--4 days after spontaneous parturition in four sows and in one sow around prostaglandin F2(~-induced parturition.Between Days --15 and --2 (Day 0 = parturition), prolactin concentrations in daily samples fluctuated somewhat, but exceeded 10 ng/ml only exceptionally. Plasma progesterone levels gradually declined or remained high until about 2 days before parturition. A final decrease of the progesterone concentrations coincided with distinct increases of the prolactin levels during the last 40 h of pregnancy.Maximal prolactin concentrations were measured before the onset of delivery of the piglets. Oestradiol-17~ reached peak values around delivery. Prostaglandin F2~ injection caused an immediate sharp increase of the prolactin concentration which lasted for about 6 h. During this period progesterone and oestradiol-17~ concentrations did not change. A second elevation of prolactin levels was measured when progesterone finally decreased.Changes of prolactin concentrations found in this study were compared with those found in other domestic animals at the same reproductive stage.

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“…The capacity of the uterus to grow and differentiate in response to circulating ovarian steroid hormones may be determined, in part, by the level of high-affinity E2 and P receptors in uterine cytoplasm (see Clark and Peck 1979 for a review). Except during the first and last 4-7 days of pregnancy, gestation in the ewe is characterized by (1) maternal peripheral serum P levels which are not less than those seen during the luteal phase of the oestrous cycle and which between days 50 and 120 increase to levels 2-5 times those seen during the luteal phase of the cycle; and (2) extremely low maternal peripheral serum levels of unconjugated oestrogens (Bassett et al 1969;Charnley et al 1973; Robertson and Smeaton 1973;Tsang 1978).…”

Section: Introductionmentioning

confidence: 99%

Uterine and Placental Growth: RNA and Protein Metabolism and Steroid Hormone Receptor Levels in the Endometrium, Whole Uterus and Cotyledons during Pregnancy in the Ewe

Miller¹,

Stone²

1981

Aust. Jnl. Of Bio. Sci.

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Some aspects of uterine and placental growth have been examined during pregnancy in the ewe. Changes in in vitro rates of protein synthesis, RNA:DNA and protein:DNA ratios and the tissue concentration of DNA in intercaruncular endometrium and caruncles/cotyledons between days 0 (oestrus) and 112 of pregnancy were compared with corresponding changes in the concentrations of high-affinity cytosol receptors for oestradiol and progesterone in whole uterus and caruncles/maternal cotyledons. Rapid growth of the intercaruncular endometrium between days 28 and 112 and of the developing cotyledons between days 28 and 84 occur in the presence of tissue levels of both steroid receptors that are extremely low in relation to the corresponding levels seen in the uterus at oestrus. If uterine responses to steroid hormones are regulated by the amounts of specific receptor present in the tissue, the results support the concept that uterine growth after day 28 of pregnancy results primarily from the physical stimulus of the growing conceptus rather than from the actions of endogenous steroid sex hormones.

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Changes in the Levels of Progesterone, Corticosteroids, Estrone, Estradiol-17 β, Luteinizing Hormone, and Prolactin in the Peripheral Plasma of the Ewe During Late Pregnancy and at Parturition

Cited by 65 publications

References 20 publications

Hormone levels in plasma of ewes induced into lactation

Hormone levels in plasma of ewes induced into lactation

Plasma prolactin, progesterone and oestradiol-17β concentrations around parturition in the pig

Uterine and Placental Growth: RNA and Protein Metabolism and Steroid Hormone Receptor Levels in the Endometrium, Whole Uterus and Cotyledons during Pregnancy in the Ewe

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