Changes in the Levels of Interleukins 6, 8, and 10, Tumor Necrosis Factor Alpha, and Granulocyte-colony Stimulating Factor in Korean Burn Patients: Relation to Burn Size and Postburn Time

Abstract

BackgroundMajor burn injury induces an inflammatory response that is accompanied by the release of various cytokines. We investigated the gradual changes in the levels of pro-inflammatory and anti-inflammatory cytokines following burn injury and determined the relationship between these levels and burn size in adult Korean patients with burn injury.MethodsBlood samples from 9 healthy controls and 60 Korean burn patients were collected on days 1, 3, 7, 14, and 21 after burn injury, and concentrations of interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor (TNF)-α, and granulocyte-colony stimulating factor (G-CSF) were measured. Burn patients were divided into 3 groups according to burn size (15-30%, 31-50%, >50% total body surface area), and the concentrations of the cytokines were compared between these groups and the control group over 3 weeks.ResultsCompared to their levels in controls, IL-6, IL-8, IL-10, TNF-α, and G-CSF levels in burn patients were significantly higher during the observation period. Median concentrations of IL-8, IL-10, and G-CSF at each time point increased with burn size, although peak levels and time to peak levels of these cytokines differed from patient to patient.ConclusionsThese findings indicate that IL-6, IL-8, IL-10, TNF-α, and G-CSF are important mediators in inflammatory changes after burn injury; however, various factors, including burn size, may influence the concentrations of these cytokines.

Melatonin attenuates oxidative stress and modulates inflammatory response after experimental burn trauma

“…A correlation exists between MDA and TNF-α in liver during burns (35) as well as between plasma TNF-α concentration and the degree of thermal damage (36). Similar data have been obtained in clinical and experimental investigations of thermal injury (37,38). But there are contradictory data about the changes of tissue and plasma TNF-α levels.…”

FXa inhibition by rivaroxaban modifies mechanisms associated with the pathogenesis of human abdominal aortic aneurysms

“…In this regard, other authors have also observed different levels of expression of IL-6 and IL-10 in inflammatory-related pathological situations. As example, Kim et al showed differences in IL-10 and IL-6 levels in the postburn time course [46]. Moreover, in human macrophages, different sensitivities of IL-6 and IL-10 signalling towards the feed-back inhibitor suppressor of cytokine signalling 3 (SOCS3) was reported, suggesting the possibility of different regulation of IL-6 and IL-10 production and, therefore, showing possible differences in the frame of the inflammatory response [47].…”

Anti-inflammatory effects of low-level laser in burn wound models in rats

“…Based on experimental models of inflammation, early expressions of TNF-α, IL-6, and IL-1β occur and play key roles. The release of pro-inflammatory mediators such as interferon-γ, TNF-α, IL-6, and IL-8 are increased in burn patients with major burn injury [27,28]. This study shows that low intensity laser therapy has a remarkable effect that inhibits TNF-α and IL-6 levels along with the reduction of edema and inflammatory responses.…”