Changes in the Leukocyte Distribution and Surface Expression of Adhesion Molecules Induced by Hypothalamic Stimulation in the Cat

Kaname, Hitoshi; Mori, Yoshinobu; Sumida, Yasuhisa; Kunihiro, Kazuaki; Kubo, Chiharu; Tashiro, Nobutada

doi:10.1006/brbi.2001.0635

Cited by 19 publications

(9 citation statements)

References 38 publications

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“…The blood adrenaline and cortisol dynamics established in previous studies, largely explain the leukopenia occurring in the three groups at various time intervals, corresponding to hormonal changes (9,15). Contrary to this, other authors did not observe changes in granulocytes and lymphocytes count in cats,…”

Section: Discussionmentioning

confidence: 65%

“…The application of α2-agonists suppresses the circulating catecholamines by exerting a modulating effect on leukocyte subpopulations (15). Dissociation agents also reduce leukocyte counts (16).…”

Section: S S U E 2 2 0 1mentioning

confidence: 99%

“…One of the possible reasons is that lymphocyte counts are mediated via β-adrenoceptor activation, while the increase in granulocytes results from α-adrenoceptor stimulation (20). Postoperative granulocytosis and lymphopenia could result from a non-specific stress response associated with postoperative and postanesthetic sympathetic and adrenocortical stimulation (15). Another probable cause with particular influence on lymphocyte counts is apoptosis.…”

Section: S S U E 2 2 0 1mentioning

confidence: 99%

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Effect Of Three Anesthetic Protocols On The Haematological Indices In Cats During Ovariohysterectomy

Zlateva¹,

Marinov²

2015

MedInform

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The investigation was performed on 21 healthy adult cats in order to evaluate the effects of three anesthetic protocols on haematological indices during the anesthesia, surgery and for a 24-hour post-surgery period. The animals were divided in to three experimental groups (n=7 in each). The first group (Х/К group) was premedicated with 2 mg/kg xylazine i.m., the second group (In group) -with 0.025 mg/kg acepromazine i.m., and the third group (ММ group) -with 0.025 mg/kg acepromazine i.m., 0.4 mg/kg butorphanol i.m. and 0.3 mg/kg metacam s.c. The induction and maintenance of anesthesia in group Х/К was done with 10 mg/kg ketamine i.v., while in the other two groups, induction with done with 5 mg/kg propofol i.v. After intubation, anesthesia was maintained with isoflurane 2.5 vol% in group In and 1.8 vol% in group ММ in oxygen flow 2.0 l/min. Blood samples were collected prior to anesthesia -0 min and at min 30, 60, 120 and hour 24 after the inception of anesthesia. A statistically significant reduction in erythrocyte counts, haemoglobin and haematocrit was observed in the three experimental groups immediately after the beginning of anesthesia. Total white blood cells count was also substantially changed, but marked decrease in leukocyte, granulocyte and lymphocyte counts in groups In and X/K were established on min 120, while in group MM -by the 60th min. The three tested anesthetic protocols decreased the studied blood parameters after the beginning of anesthesia, most probably as a result of neuro-hormonal interactions of the anesthetic drugs and the related blood volume redistribution.

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Section: Discussionmentioning

confidence: 65%

Section: S S U E 2 2 0 1mentioning

confidence: 99%

Section: S S U E 2 2 0 1mentioning

confidence: 99%

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Effect Of Three Anesthetic Protocols On The Haematological Indices In Cats During Ovariohysterectomy

Zlateva¹,

Marinov²

2015

MedInform

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“…Control samples for each antibody, prepared with subclass matched irrelevant mAbs, were run in parallel to identify non-specific background fluorescence. The mAbs with human or dog as target species either reacted with cat according to the manufacturer (CD11b, CD18, and CD21) or had previously been shown to cross-react with feline leukocytes (CD11a and CD49d) (Kaname et al, 2002). For mAbs raised against human antigens with unknown feline cross-reactivity (CD15s and CD54), the tissue distribution and fluorescence patterns of the antigens recognized by these mAbs were determined in cat and were almost identical to those of humans indicating that the mAbs recognized the cat homologues of the human antigens.…”

Section: Cell Labelingmentioning

confidence: 99%

Altered expression of adhesion molecules on peripheral blood leukocytes in feline infectious peritonitis

Olyslaegers

Dedeurwaerder

Desmarets

et al. 2013

Veterinary Microbiology

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Feline infectious peritonitis (FIP) is a fatal, coronavirus-induced systemic disease in domestic and wild felids. The pathology associated with FIP (multifocal granulomatous vasculitis) is considered to be elicited by exaggerated activation and subsequent extravasation of leukocytes. As changes in the expression of adhesion molecules on circulating leukocytes precede their margination and emigration, we reasoned that the expression of leukocyte adhesion molecules may be altered in FIP. In present study, the expression of principal adhesion molecules involved in leukocyte transmigration (CD15s, CD11a, CD11b, CD18, CD49d, and CD54) on peripheral blood leukocytes from cats with naturally occurring FIP (n=15) and controls (n=12) was quantified by flow cytometry using a formaldehyde-based rapid leukocyte preparation technique. T- and B-lymphocytes from FIP patients exhibit higher expression of both subunits (CD11a and CD18) composing the β2 integrin lymphocyte function-associated antigen (LFA)-1. In addition, the expression of the α4 subunit (CD49d) of the β1 integrin very late antigen (VLA)-4 was elevated on B-lymphocytes from FIP patients. The expression of CD11b and CD18, that combine to form the β2 integrin macrophage-1 antigen (Mac-1), was elevated on monocytes, whereas the density of CD49d was reduced on this population in FIP. Granulocytes of FIP cats displayed an increased expression of the α chain of Mac-1 (CD11b). These observations suggest that leukocytes from FIP patients show signs of systemic activation causing them to extravasate into surrounding tissues and ultimately contribute to pyogranuloma formation seen in FIP.

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“…Unfortunately, when stressful events persist, the immune system can become compromised. Various studies have shown that stimulation of targeted areas in the feline brain that are associated with emotions such as fear, anxiety, and restlessness can alter cell-mediated immunity [ 9 , 10 , 11 , 12 ]. These stressful events can also cause immunosuppression through inhibition of mucosal antibodies [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Frequency and Duration of Handling on the Development of Feline Upper Respiratory Infections in a Shelter Setting

Burns¹,

Redding

Watson

2020

Animals

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Reducing stress is important to maintaining the health of shelter cats and decreasing the risk of upper respiratory disease (URD). The aim of this study was to determine if the frequency and/or duration of daily routine handling of shelter cats affects the likelihood of URD development. At a closed admission shelter, each cat free of URD on intake was given a cage card for recording handling data. These data included: date and times when the cat was handled, duration of handling, if and when the cat developed signs of URD, and the handler identity. Cox regression was used to determine the relationship between these factors and URD development. We found cats that did not develop URD were handled significantly more than cats that did (1.1 times per day vs. 0.7 times per day, p < 0.001). Increased frequency of handling had a borderline significant effect on the hazard of developing URD (HR 0.37; CI: 0.13–1.1; p = 0.066). No other parameters were significantly associated with the development of URD; however, small sample size may be responsible for this finding. A larger study is needed to elucidate the relationship between handling and URD development.

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Changes in the Leukocyte Distribution and Surface Expression of Adhesion Molecules Induced by Hypothalamic Stimulation in the Cat

Cited by 19 publications

References 38 publications

Effect Of Three Anesthetic Protocols On The Haematological Indices In Cats During Ovariohysterectomy

Effect Of Three Anesthetic Protocols On The Haematological Indices In Cats During Ovariohysterectomy

Altered expression of adhesion molecules on peripheral blood leukocytes in feline infectious peritonitis

The Effects of Frequency and Duration of Handling on the Development of Feline Upper Respiratory Infections in a Shelter Setting

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