Changes in the incidence of tuberculosis in a cohort of HIV-seroconverters before and after the introduction of HAART

Muga, Roberto; Ferreros, Inmaculada; Langohr, Klaus; Olalla, Patricia García de; Romero, Jorge del; Quintana, Manuel; Alastrué, Ignacio; Belda, J; Tor, Jordi; Pérez-Hoyos, Santiago; Amo, Julia del

doi:10.1097/qad.0b013e3282f1c933

Cited by 39 publications

(30 citation statements)

References 20 publications

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“…Thus, cumulative incidence of Tuberculosis (21.4%) reported in this study was lower than study done in former capital of Tanzania, Dares Salaam (27.1%) and study done in North west Ethiopia (Debre Markos hospital) (44%) [21]. But, the finding was higher than studies done in Spain and Brazil which were 7.7% [22], and 4.62% [23] respectively. Higher incidence rate could be explained by the fact that unlike these two countries, Ethiopia is one of the high TB burden countries in the world [24] besides advanced economic development compared to Ethiopia might improve HIV chronic care and reduce occurrence of TB.…”

Section: Discussioncontrasting

confidence: 68%

Incidence and Predictors of Tuberculosis among HIV/AIDS Infected Patients: A Five-Year Retrospective Follow-Up Study

Dalbo¹,

Tamiso²

2016

AID

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Background: Despite increased deliverance of antiretroviral therapy (ART), morbidity and mortality from TB are still predominant among HIV/AIDS infected patients in Ethiopia. Thus, current study aimed to determine magnitude and predictors of tuberculosis among cohort of HIV infected patients at Arba Minch General Hospital, Ethiopia, 2015. Methods: Hospital based retrospective follow-up study was conducted among study population which was HIV/AIDS infected individuals registered from September 2007 to 2013. The data were collected using structured data abstraction form and four ART trained nurses were used to abstract the data. The data were checked for completeness, cleaned and entered into Epi Info 7.0 and analyzed using SPSS version (IBM-21). Results were summarized by using table of frequency, graph, and measure of central tendency. Statistical significance was inferred at P-value ≤ 0.05. Adjusted odd ratio (AOR) with 95% confidence interval (CI) was used to determine predictors. Result: Four hundred ninety six patient's charts were abstracted. Cumulative and incidence density of tuberculosis were 21.4% (95% CI: 21.3, 21.44) and 5.36 per 100 person year respectively. Cigarette smokers (AOR: 2.82, 95% CI (1.27 -6.27)), household with family size of 3 -4 (AOR: 2.26, 95% CI (1.14 -4.50)), baseline WHO clinical stage III (AOR: 20.26, 95% CI (7.09 -57.6)) and IV (AOR: 22.9, 95% CI (6.91 -76.4)) and heamoglobin level of <10 (AOR: 2.56, 95% CI (1.22 -5.33)) were important predictors (risk factors) of tuberculosis among HIV infected patients. Conclusion and recommendation: Relatively high incident tuberculosis cases were established among HIV infected patients and history of cigarette smoking; family size; hemoglobin level and base line WHO clinical stage were responsible for this incidence. Therefore; early initiation of HAART as per current guideline should get stressed, and the finding that smoking was important predictors for TB in Ethiopia had obvious TB control implication which required high attention focused on fighting against cigarette smoking among HIV infected cohort.

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Section: Discussioncontrasting

confidence: 68%

Incidence and Predictors of Tuberculosis among HIV/AIDS Infected Patients: A Five-Year Retrospective Follow-Up Study

Dalbo¹,

Tamiso²

2016

AID

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“…16,20 It is important to identify undiagnosed HIV patients early as effective anti-retroviral treatment is currently available, and treatment has been shown to decrease the risk of developing TB subsequently. 21 End-stage renal failure significantly weakens the patient's immunity, and this increases their susceptibility to develop TB as well. 22,23 Diabetes mellitus is one of the most common chronic metabolic disorders in developed countries, and it can lead to end-stage renal failure.…”

Section: Discussionmentioning

confidence: 99%

The Spectrum of Abdominal Tuberculosis in a Developed Country: A Single Institution’s Experience Over 7 Years

Tan

Chen

Sim

2009

Journal of Gastrointestinal Surgery

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“…This reflects the more prominent transmission of HIV through males having sex with males and via injection of drugs, since a higher proportion of drug users is male [31,32]. Co-infection was more prevalent in the 15-45-yr age group in five studies, reflecting the higher proportion of HIV in this group, or more frequent HIV testing in young adult TB cases [21,29,30]. Five out of seven countries where the data were available showed a majority of the TB-HIV co-infected patients to be born abroad.…”

Section: Risk Factors/groups For Tb-hiv Co-infectionmentioning

confidence: 99%

Tuberculosis and HIV co-infection in European Union and European Economic Area countries

Pimpin

Drumright²,

Kruijshaar³

et al. 2011

Eur Respir J

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In order to ensure the availability of resources for tuberculosis (TB) and HIV management and control, it is imperative that countries monitor and plan for co-infection in order to identify, treat and prevent TB-HIV co-infection, thereby reducing TB burden and increasing the years of healthy life of people living with HIV.A systematic review was undertaken to determine the burden of TB-HIV infection in the European Union (EU) and European Economic Area (EEA). Data on the burden of HIV infection in TB patients and risk factors for TB-HIV co-infection in the EU/EEA were extracted from studies that collected information in 1996 and later, regardless of the year of initiation of data collection, and a narrative synthesis presented.The proportion of HIV-co-infected TB patients varied from 0 to 15%. Western and eastern countries had higher levels and increasing trends of infection over time compared with central EU/EEA countries. Groups at higher risk of TB-HIV co-infection were males, young adults, foreignborn persons, the homeless, injecting drug users and prisoners.Further research is needed into the burden and associated risk factors of co-infection in Europe, to help plan effective control measures. Increased HIV testing of TB patients and targeted and informed strategies for control and prevention could help curb the co-infection epidemic.

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Changes in the incidence of tuberculosis in a cohort of HIV-seroconverters before and after the introduction of HAART

Abstract: Since the mid-1990s important decreases in tuberculosis have been observed in HIV-seroconverters that probably reflect the impact of both HAART and tuberculosis control programmes.

Cited by 39 publications

References 20 publications

Incidence and Predictors of Tuberculosis among HIV/AIDS Infected Patients: A Five-Year Retrospective Follow-Up Study

Incidence and Predictors of Tuberculosis among HIV/AIDS Infected Patients: A Five-Year Retrospective Follow-Up Study

The Spectrum of Abdominal Tuberculosis in a Developed Country: A Single Institution’s Experience Over 7 Years

Tuberculosis and HIV co-infection in European Union and European Economic Area countries

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