Changes in the Immune Components of Preterm Human Milk and Associations With Maternal and Infant Characteristics

Groër, Maureen; Ashmeade, Terri; Duffy, Allyson; Morse, Shannon; Zaritt, Judy

doi:10.1016/j.jogn.2016.04.009

Cited by 14 publications

(21 citation statements)

References 32 publications

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“…As stated above, several factors have been suggested to affect the immune composition of human milk, including the health status of the mother-infant dyad (18, 20, 79–81). Increased exposure to pathogens, as those occurring in clinical and subclinical mastitis (82, 83) and during infectious disease of the breastfed infant (84–86), might relate to increased pro-inflammatory factors in human milk.…”

Section: Discussionmentioning

confidence: 99%

What’s Normal? Immune Profiling of Human Milk from Healthy Women Living in Different Geographical and Socioeconomic Settings

et al. 2017

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Human milk provides a very wide range of nutrients and bioactive components, including immune factors, human milk oligosaccharides, and a commensal microbiota. These factors are essential for interconnected processes including immunity programming and the development of a normal infant gastrointestinal microbiome. Newborn immune protection mostly relies on maternal immune factors provided through milk. However, studies dealing with an in-depth profiling of the different immune compounds present in human milk and with the assessment of their natural variation in healthy women from different populations are scarce. In this context, the objective of this work was the detection and quantification of a wide array of immune compounds, including innate immunity factors (IL1β, IL6, IL12, INFγ, TNFα), acquired immunity factors (IL2, IL4, IL10, IL13, IL17), chemokines (IL8, Groα, MCP1, MIP1β), growth factors [IL5, IL7, epidermal growth factor (EGF), granulocyte colony-stimulating factor, granulocyte–macrophage colony-stimulating factor, TGFβ2], and immunoglobulins (IgA, IgG, IgM), in milk produced by healthy women of different ethnicities living in different geographic, dietary, socioeconomic, and environmental settings. Among the analyzed factors, IgA, IgG, IgM, EGF, TGFβ2, IL7, IL8, Groα, and MIP1β were detected in all or most of the samples collected in each population and, therefore, this specific set of compounds might be considered as the “core” soluble immune factors in milk produced by healthy women worldwide. This approach may help define which immune factors are (or are not) common in milk produced by women living in various conditions, and to identify host, lifestyle, and environmental factors that affect the immunological composition of this complex biological fluid.Clinical Trial Registration: , identifier NCT02670278.

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Section: Discussionmentioning

confidence: 99%

What’s Normal? Immune Profiling of Human Milk from Healthy Women Living in Different Geographical and Socioeconomic Settings

et al. 2017

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“…This study was conducted using secondary data. VLBW infant participants were part of a larger longitudinal study of long-term growth, health, and neurodevelopmental effects (Groer, Ashmeade, Duffy, Morse, & Zaritt, 2016;Groer, Ashmeade, Louis-Jacques, Beckstead, & Ji, 2016;Ho et al, 2018). Infants were admitted to the neonatal intensive care unit at Tampa General Hospital in Tampa, Florida between 2011 and 2015.…”

Section: Participantsmentioning

confidence: 99%

Effects of early life NICU stress on the developing gut microbiome

D'Agata

Welandawe

et al. 2019

Developmental Psychobiology

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Succession of gut microbial community structure for newborns is highly influenced by early life factors. Many preterm infants cared for in the NICU are exposed to parent–infant separation, stress, and pain from medical care procedures. The purpose of the study was to investigate the impact of early life stress on the trajectory of gut microbial structure. Stool samples from very preterm infants were collected weekly for 6 weeks. NICU stress exposure data were collected daily for 6 weeks. V4 region of the 16S rRNA gene was amplified by PCR and sequenced. Zero‐inflated beta regression model with random effects was used to assess the impact of stress on gut microbiome trajectories. Week of sampling was significant for Escherichia, Staphylococcus, Enterococcus, Bifidobacterium, Proteus, Streptococcus, Clostridium butyricum, and Clostridium perfringens. Antibiotic usage was significant for Proteus, Citrobacter, and C. perfringens. Gender was significant for Proteus. Stress exposure occurring 1 and 2 weeks prior to sampling had a significant effect on Proteus and Veillonella. NICU stress exposure had a significant effect on Proteus and Veillonella. An overall dominance of Gammaproteobacteria was found. Findings suggest early life NICU stress may significantly influence the developing gut microbiome, which is important to NICU practice and future microbiome research.

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“…Молозиво является первым секретом, который синтезируется молочными железами в первые дни после родов [5,6,7,8]. Ряд зарубежных исследований свидетельствует о том, что грудное молоко, у женщин родивших раньше срока, содержит более высокую концентрацию иммунологических компонентов, в частности sIgA, чем у женщин, родивших в срок [9,10]. Данный факт и определил цель настоящего исследования.…”

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Concentration of secretory IgA in colostrum and breast milk of women who gave birth ahead of time

SHakirova¹,

Chistyakova²,

Ремизова³

et al. 2020

TDSE

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Changes in the Immune Components of Preterm Human Milk and Associations With Maternal and Infant Characteristics

Cited by 14 publications

References 32 publications

What’s Normal? Immune Profiling of Human Milk from Healthy Women Living in Different Geographical and Socioeconomic Settings

What’s Normal? Immune Profiling of Human Milk from Healthy Women Living in Different Geographical and Socioeconomic Settings

Effects of early life NICU stress on the developing gut microbiome

Concentration of secretory IgA in colostrum and breast milk of women who gave birth ahead of time

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