Changes in the Human Gut Microbiome Caused by the Short-Term Impact of Lactic Acid Bacteria Consumption in Healthy People

Gryaznova, Mariya; Smirnova, Yuliya; Burakova, Inna; Syromyatnikov, Mikhail; Chizhkov, Pavel; Попов, Е. С.; Popov, Vasily N.

doi:10.1007/s12602-023-10111-4

Cited by 7 publications

(3 citation statements)

References 82 publications

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“…Fusicatenibacter on the other hand, plays a beneficial role. Known for producing short-chain fatty acids (Gryaznova et al, 2023) and degrading inulin polysaccharides, it also secretes interleukin-10 (IL-10), an antiinflammatory cytokine (Takada et al, 2013;Takeshita et al, 2016). IL-10, a negative-feedback regulator cytokine, inhibits production of inflammatory cytokines like interleukin-1 (IL-1), TNF-a, and interleukin-12 (IL-12) from macrophages and suppresses T cell activation by inhibiting the expression of costimulators and MHCII on macrophages and dendritic cells (DCs) (Sziksz et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota influence acute pancreatitis through inflammatory proteins: a Mendelian randomization analysis

Huang,

Liu,

Zhang

et al. 2024

Front. Cell. Infect. Microbiol.

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Background/AimWe employed Mendelian randomization (MR) analysis to investigate the causal relationship between the gut microbiota, acute pancreatitis, and potential inflammatory proteins.MethodsThe data for gut microbiota, acute pancreatitis, and inflammatory proteins are sourced from public databases. We conducted a bidirectional MR analysis to explore the causal relationship between gut microbiota and acute pancreatitis, and employed a two-step MR analysis to identify potential mediating inflammatory proteins. IVW is the primary analysis method, heterogeneity, pleiotropy, and sensitivity analyses were also conducted simultaneously.ResultsWe identified five bacterial genera associated with the risk of acute pancreatitis, namely genus.Coprococcus3, genus.Eubacterium fissicatena group, genus.Erysipelotrichaceae UCG-003, genus.Fusicatenibacter, and genus.Ruminiclostridium6. Additionally, we have discovered three inflammatory proteins that are also associated with the occurrence of acute pancreatitis, namely interleukin-15 receptor subunit alpha (IL-15RA), monocyte chemoattractant protein-4 (CCL13), and tumor necrosis factor receptor superfamily member 9 (TNFRSF9). Following a two-step MR analysis, we ultimately identified IL-15RA as a potential intermediate factor, with a mediated effect of 0.018 (95% CI: 0.005 - 0.032).ConclusionOur results support the idea that genus.Coprococcus3 promotes the occurrence of acute pancreatitis through IL-15RA. Furthermore, there is a potential causal relationship between the gut microbiota, inflammatory proteins, and acute pancreatitis. These findings provide new insights for subsequent acute pancreatitis prevention.

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Section: Discussionmentioning

confidence: 99%

Gut microbiota influence acute pancreatitis through inflammatory proteins: a Mendelian randomization analysis

Huang,

Liu,

Zhang

et al. 2024

Front. Cell. Infect. Microbiol.

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“…Lactic acid bacteria comprise the main microorganisms used in the production of fermented foods, and they play key roles in the fermentation of dairy products, meat, fruits, and vegetables. Lactic acid bacteria are major probiotics within the human intestinal ecosystem, where they mainly colonize the duodenum through to the terminal ileum [ 6 ]. Empirical insights derived from a study conducted by Dimidi et al [ 4 ] suggest that the ingestion of lactic acid bacteria and their metabolites can potentially elicit immune system stimulation, augment gastrointestinal function, and have favorable impacts on the blood glucose levels and cholesterol.…”

Section: Introductionmentioning

confidence: 99%

“…Empirical insights derived from a study conducted by Dimidi et al [ 4 ] suggest that the ingestion of lactic acid bacteria and their metabolites can potentially elicit immune system stimulation, augment gastrointestinal function, and have favorable impacts on the blood glucose levels and cholesterol. Furthermore, Gryaznova et al [ 6 ] showed that specific strains of lactic acid bacteria present in sauerkraut produce conjugated linoleic acid, which may have anti-cancer and anti-atherosclerotic properties. Yeasts comprise another category of microorganism with extensive applications in the fermentation of foods, where they impart distinctive organoleptic properties and enhance the nutritional contents [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Impact of Pineapple–Whey Protein Fermentation Products on Cefixime-Induced Intestinal Flora Dysbiosis in Mice Using 16S Sequencing and Untargeted Metabolomics Techniques

Luo,

Xiao,

et al. 2024

Foods

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In our previous study, a new fermented food (PWF) created by utilizing pineapple by-products and whey proteins as a matrix via co-fermentation with lactic acid bacteria and yeast was developed, and, in the current study, we examined the impact of a pineapple–whey protein fermentation product on a cefixime-induced dysbiosis model in mice using 16S sequencing and untargeted metabolomics techniques. The results indicated that the pineapple–whey protein fermentation product played a positive role in restoring the intestinal flora. In this study, cefixime reduced the overall abundance of intestinal flora and decreased the relative abundance of probiotics in the gut, while also inhibiting amino acid metabolism. The addition of PWF normalized the intestinal flora to a steady state, significantly increasing the populations of Weissella, Lactococcus, Faecalibaculum, and Bacteroides acidophilus, while decreasing the numbers of Akkermansia and Escherichia-Shigella. Additionally, PWF modulated microbial metabolites, such as L-glutamate and L-threonine, and upregulated amino-acid-related metabolic pathways, including those involving glycine, serine, and threonine. In conclusion, PWF can alleviate intestinal flora dysbiosis and metabolic disturbances induced by antibiotic interventions. It is suggested that PWF could be a potential dietary strategy for patients with antibiotic-associated diarrhea.

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Effects of gut bacteria and their metabolites on gut health of animals

Hao,

Ding,

Wang

2024

Advances in Applied Microbiology

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Changes in the Human Gut Microbiome Caused by the Short-Term Impact of Lactic Acid Bacteria Consumption in Healthy People

Cited by 7 publications

References 82 publications

Gut microbiota influence acute pancreatitis through inflammatory proteins: a Mendelian randomization analysis

Gut microbiota influence acute pancreatitis through inflammatory proteins: a Mendelian randomization analysis

Investigating the Impact of Pineapple–Whey Protein Fermentation Products on Cefixime-Induced Intestinal Flora Dysbiosis in Mice Using 16S Sequencing and Untargeted Metabolomics Techniques

Effects of gut bacteria and their metabolites on gut health of animals

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