Changes in the Growth Hormone‐IGF‐I Axis in Non‐obese Diabetic Mice

Abstract

We investigated the changes in GH-IGF-I axis in non-obese diabetic

Inhibitory effects of octreotide on renal and glomerular growth in early experimental diabetes in mice

“…In contrast, human diabetes is characterised by GH hypersecretion positively correlated to the diabetic aberration (Yde 1969, Hansen & Johansen 1970, Hansen 1972. In concert with this we observed elevated barbital-stimulated GH levels in the present study, which have been demonstrated previously in the same model (Flyvbjerg et al 1999) and also in NOD mice (Landau et al 2000). It is therefore suggested that the diabetic mouse models, with respect to changes in GH, mimic human type 1 diabetes better than diabetic rats.…”

Cachexia in the non‐obese diabetic mouse is associated with CD4+ T‐cell lymphopenia

“…Although evidence of apoptosis has been described in cancer cachexia, 18,19,52 it has not been reported in chemically-induced diabetic rats. 53 Insulin-like growth factor-1 (IGF-1), a protein that is significantly reduced both in human TID 54 and in the diabetic NOD mouse, 55 inhibits caspase 3-mediated apoptosis. 56 Therefore, it is tempting to speculate that the mechanism for TID-induced cachexia involves apoptosis by a mechanism that involves a deficiency in IGF-1, and that the NOD model of cachexia provides a model to study mechanisms of apoptosis that are specific to TID cachexia.…”

Expression of liver insulin-like growth factor 1 gene and its serum level in rats with diabetes

“…Some studies showed that tissue IGF-1 gene expression might be affected by systemic or local factors or both in diabetes, i.e. decrease of GH receptors in target cells and its binding affinity [13] , and by reduced or absent pulsatile pattern secretion of GH, metabolic abnormality of insulin like growth factor binding proteins (IGFBPs) [6,14] , negative nitrogen balance [15,16] etc. All these may probably lead to a decline of IGF-1.…”