Changes in the Fatty Acid Composition of Plasma Lipoproteins during Administration of Intralipid to a Patient with Essential Fatty Acid Deficiency

Abstract

1. The fatty acid composition of the cholesterol esters, triglycerides and lecithin components of the major plasma lipoprotein classes was determined before and after the intravenous infusion of a linoleate preparation into a patient with essential fatty acid deficiency.2. Marked differences developed between the fatty acid composition of the cholesterol esters of very-low-density lipoprotein (VLDL) on the one hand and of low-and high-density lipoproteins (LDL and HDL) on the other hand.3. The data suggest that the infused linoleate was selectively incorporated into LDL and HDL cholesterol esters by the action of plasma lecithin4holesterol acyltransferase, after prior incorporation into lipoprotein lecithin. In contrast, there was no rise in the linoleate content of VLDL cholesterol esters, which probably originated in either the liver or the small intestine. 4. These findings support the concept that plasma cholesterol esters are heterogeneous.Key words : lipoprotein, cholesterol ester, linoleic acid, essential fatty acid deficiency.Recent results (Shimoyama, Kikuchi, Press & Thompson, 1973) confirm previously published data which show that the fatty acid composition of very-low-density lipoprotein (VLDL) cholesterol esters differs from that of low-or high-density lipoproteins (LDL and HDL)