Changes in the Etiology of Endophthalmitis from 2003 to 2010 in a Large Tertiary Medical Center

Kessner, Rivka; Golan, Shani; Barak, Adiel

doi:10.5301/ejo.5000473

Cited by 19 publications

(18 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The U.S. Food and Drug Administration (FDA) approved intravitreal anti-vascular endothelial growth factor (anti-VEGF) medications to treat neovascular age-related macular degeneration in 2004, and since then, there has been a rapid increase in the use of these and other intravitreal injections. Some centers report that postinjection endophthalmitis is now more common than postoperative endophthalmitis (3,10).…”

Section: Introductionmentioning

confidence: 99%

Bacterial and Fungal Endophthalmitis

2017

View full text Add to dashboard Cite

Endophthalmitis is a severe eye infection that may result in permanent loss of useful vision in the affected eye. Most cases are exogenous and occur as a complication of cataract surgery, an intravitreal injection, or penetrating ocular trauma. Endogenous endophthalmitis results from hematogenous seeding of the eye by bacteria or fungi, but bacteremia or fungemia may be transient and patients may present without symptoms of systemic infection. Nearly all endophthalmitis patients present with decreased vision, and some also have eye pain. Eye examination usually reveals a hypopyon and intraocular inflammation. Diagnosis is clinical, supported by cultures of the vitreous and/or aqueous or by blood cultures in some endogenous cases. Molecular diagnostic techniques have been used in research laboratories for pathogen identification in endophthalmitis and offer the possibility of rapid diagnosis, including in culture-negative cases. Intravitreal injection of antibiotics is the most important component of treatment; some cases also benefit from surgical debridement of the vitreous by a vitrectomy. The visual outcome depends partly on the pathogen: coagulase-negative staphylococcal endophthalmitis has a better prognosis than does streptococcal endophthalmitis, for example. Endophthalmitis is a medical emergency, and prompt diagnosis and treatment are essential for saving vision.

show abstract

Section: Introductionmentioning

confidence: 99%

Bacterial and Fungal Endophthalmitis

2017

View full text Add to dashboard Cite

show abstract

“…One 2014 single-center series reported that the primary cause of endophthalmitis in that institution changed from post-surgical in 2003 to post-injection in 2010 [4]. There is growing understanding of the additional risks posed by the use of off-label medications and surgical adjuncts prepared by compounding pharmacies, with several recent reported series, including Streptococcus mitis/oralis endophthalmitis following injection of bevacziumab (Avastin, Genentech, South San Francisco, CA) [5], Bipolaris hawaiiensis endophthalmitis following injection of triamcinolone [6], Bipolaris hawaiiensis endophthalmitis following injection of combined bevacizumab and triamcinolone [7], and Fusarium incarnatum-equiseti species complex endophthalmitis following the use of Brilliant Blue G dye during PPV [8].…”

Section: Endophthalmitis After Pars Plana Vitrectomy (Ppv) and Intravmentioning

confidence: 99%

Update on the prevention and treatment of endophthalmitis

Schwartz

Flynn

2014

Expert Review of Ophthalmology

View full text Add to dashboard Cite

SUMMARY Endophthalmitis remains a rare but serious cause of visual loss. Over time, changes have been noted in endophthalmitis in terms of predominant causes, infecting organisms, and antibiotic susceptibilities. There is controversy regarding the use of intracameral prophylactic antimicrobials during cataract surgery. Alternatively, there appears to be increasing evidence against using routine topical antibiotics for intravitreal injections. There are also increasing reports of multidrug-resistant organisms causing endophthalmitis, but the combination of vancomycin and ceftazidime appears effective for the vast majority of cases. Future trends may involve increasing utilization of polymerase chain reaction for diagnosis, and possibly office-based pars plana vitrectomy for treatment of endophthalmitis.

show abstract

“…A incidência média de endoftalmite pós-operatória (EPO) é de 0,13% 1,[8][9][10][11] . No entanto, a ocorrência em cenário de surto pode ser devastadora, devido ao grande número de cirurgias de catarata normalmente realizadas em um único dia, expondo os pacientes a fatores de risco similares [12][13][14] .…”

Section: Introductionunclassified

Seleção de marcadores para a busca ativa de endoftalmite após cirurgia de catarata

Luz

Cvintal²,

Silva³

et al. 2018

Rev SOBECC

View full text Add to dashboard Cite

Objetivo: Identificar marcadores potenciais para auxiliar na busca ativa de endoftalmite após cirurgia de catarata. Método: Estudo retrospectivo, descritivoe longitudinal, realizado por meio da revisão de prontuários de pacientes submetidos à cirurgia de catarata. Resultados: A amostra incluiu 20 pacientes(grupo de estudo — GE) que desenvolveram endoftalmite pós-operatória e 309 pacientes (grupo controle — GC) que não apresentaram endoftalmite. Os dadosforam analisados para identificar os marcadores clínicos e epidemiológicos com uma diferença percentual ≥30% entre os grupos. Em comparação com o GC,o GE teve frequência ≥30% em: sinais e sintomas pós-operatórios definidos (dor, reação da câmara anterior, hipópio, edema da córnea, hiperemia conjuntivale opacidade vítrea); mais de 4 retornos pós-operatórios; e realização de injeção de antibiótico intravítreo. Conclusão: Os indicadores selecionados são sugeridospara incorporação na busca ativa das infecções pós-operatórias de endoftalmite, visando à facilidade operacional do sistema de vigilância epidemiológica.

show abstract

Changes in the Etiology of Endophthalmitis from 2003 to 2010 in a Large Tertiary Medical Center

Abstract: The leading etiology of endophthalmitis changed from postoperative endophthalmitis to endophthalmitis after IVT injection from 2003 to 2010, and the incidence of the infection as a complication of those procedures decreased.

Cited by 19 publications

References 11 publications

Bacterial and Fungal Endophthalmitis

Bacterial and Fungal Endophthalmitis

Update on the prevention and treatment of endophthalmitis

Seleção de marcadores para a busca ativa de endoftalmite após cirurgia de catarata

Contact Info

Product

Resources

About