Changes in the Endogenous Ouabain-like Substance in the Brain and Cerebrospinal Fluid after Cold-induced Vasogenic Brain Edema

Rap, Z. M.; Schoner, Wilhelm; Czernicki, Z; Hildebrandt, Gerhard; Mueller, W.A.; Hoffmann, Oskar

doi:10.1007/978-3-642-72511-1_141

Cited by 2 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pituitary ouabain is considered to be released into the circulation but paracrine secretion may occur. Cold‐induced brain edema in cats leads to a significant increase in ouabain‐like activity in the cerebrospinal fluid and the edematous brain hemisphere [68]. In conscious rats, acute intracerebroventricular injection of ouabain or crude hypothalamic or pituitary extracts containing ouabain‐like activity causes similar increases in sympathetic activity, blood pressure, and heart rate.…”

Section: Physiology and Pathophysiology Of Endogenous Ouabainmentioning

confidence: 99%

Endogenous cardiac glycosides, a new class of steroid hormones

Schoner

2002

European Journal of Biochemistry

315

274

View full text Add to dashboard Cite

The search for endogenous digitalis has led to the isolation of ouabain as well as several additional cardiotonic steroids of the cardenolide and bufadienolide type from blood, adrenals, and hypothalamus. The concentration of endogenous ouabain is elevated in blood upon increased Na + uptake, hypoxia, and physical exercise. Changes in blood levels of ouabain upon physical exercise occur rapidly. Adrenal cortical cells in tissue culture release ouabain upon addition of angiotensin II and epinephrine, and it is thought that ouabain is released from adrenal cortex in vivo. Ouabain levels in blood are elevated in 50% of Caucasians with low-renin hypertension. Infusion over several weeks of low concentrations of ouabain, but not of digoxin, induces hypertension in rats. A digoxin-like compound, which has been isolated from human urine and adrenals, as well various other endogenous cardiac glycosides may counterbalance their actions within a regulatory framework of water and salt metabolism. Marinobufagenin, for instance, whose concentration is increased after cardiac infarction, may show natriuretic properties because it inhibits the a1 isoform of Na + /K + -ATPase, the main sodium pump isoform of the kidney, much better than other sodium pump isoforms. In analogy to other steroid hormones, cardiotonic steroid hormones in blood are bound to a specific cardiac glycoside binding globulin. The discovery of ouabain as a new adrenal hormone affecting Na + metabolism and the development of the new ouabain antagonist PST 2238 allows for new possibilities for the therapy of hypertension and congestive heart failure. This will lead in turn to a better understanding of the disease on a physiological and endocrinological level and of the action of ouabain on the cellular level as a signal that is transduced to the plasma membrane as well as to the cell nucleus.

show abstract

Section: Physiology and Pathophysiology Of Endogenous Ouabainmentioning

confidence: 99%

Endogenous cardiac glycosides, a new class of steroid hormones

Schoner

2002

European Journal of Biochemistry

315

274

View full text Add to dashboard Cite

show abstract

“…The pituitary ouabain is thought to be released into the circulation from the pituitary but paracrine secretion from other nuclei is possible. Cold-induced brain edema in cats leads to a significant increase in of ouabain-like activity in the cerebrospinal fluid and the edematous brain hemisphere (Rap et al, 1994). In conscious rats, acute intracerebroventricular injection of ouabain causes increased sympathetic activity, blood pressure, and heart rate.…”

Section: Physiology and Pathophysiology Of Endogenous Ouabainmentioning

confidence: 99%

Ouabain, a new steroid hormone of adrenal gland and hypothalamus

Schoner

2000

Exp Clin Endocrinol Diabetes

Self Cite

View full text Add to dashboard Cite

Ouabain has been isolated and identified as a constituent of human blood, bovine adrenal glands and hypothalamus. This water soluble inhibitor of the sodium pump (Na+/K+-ATPase) circulates in elevated concentrations in blood plasma of 50% of Caucasians with elevated blood pressure. It is released from adrenal cortical cells in tissue culture by angiotensin II. A ouabain antagonist, PST2238, lowers blood pressure in hypertensive rats. Hence, ouabain is most probably a new steroid hormone formed in adrenal glands and hypothalamus. Consistent therewith is the demonstration of a specific binding globulin for cardiac glycosides in blood plasma.

show abstract

Changes in the Endogenous Ouabain-like Substance in the Brain and Cerebrospinal Fluid after Cold-induced Vasogenic Brain Edema

Cited by 2 publications

References 11 publications

Endogenous cardiac glycosides, a new class of steroid hormones

Endogenous cardiac glycosides, a new class of steroid hormones

Ouabain, a new steroid hormone of adrenal gland and hypothalamus

Contact Info

Product

Resources

About