Changes in the elasticity of fibroadenoma during the menstrual cycle determined by real-time sonoelastography

Kılıç, Fahrettin; Kayadibi, Yasemin; Kocael, Pınar; Velidedeoğlu, Mehmet; Baş, Ahmet; Bakan, Selim; Aydoğan, Fatih; Karataş, Adem; Yılmaz, Mehmet

doi:10.1016/j.ejrad.2015.03.006

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…Because of the small sample size, we did not have the statistical power to examine possible differences in refractivity and attenuation between the two groups (with or without contraceptives). We note, however, that other studies found no significant difference between estrogen level and glandular tissue elasticity measurements using sonoelastography (6,15) or significant differences during the MC using diffusion-weighted imaging (16,17).…”

Section: Discussioncontrasting

confidence: 72%

“…For example, Kilic et al. were able to demonstrate significant changes of shear-wave elastography values within fibroadenoma (6). Also, mammography in premenopausal women had higher diagnostic accuracy when it was performed during the first week of their menstrual cycle (MC) (7), although the change of density between the luteal and follicular phases is low and was in the range of 7.1–9.2% (8).…”

Section: Introductionmentioning

confidence: 99%

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Does the menstrual cycle affect the multimodal ultrasound tomography?

et al. 2018

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Background Multimodal ultrasound tomography (MUT) is a promising new three-dimensional imaging technology for breast cancer detection without ionizing radiation or need for tissue compression. It offers an automatic scan of the pendulant whole breast. Purpose As breast tissue properties are affected by the menstrual cycle (MC), we examined whether there is an objective difference in the refractivity and attenuation images obtained via MUT at different phases of the menstrual cycle. Material and Methods Thirteen asymptomatic volunteers (age range = 27–44 years) with a regular MC were scanned once weekly for four weeks. Attenuation and refractivity images of the breast coronal slices obtained via MUT are calibrated against precisely controlled water-through values of the ultrasound waves. The average of attenuation and refractivity values measured in the MUT images were calculated for each volunteer every week. Results During the MC, the weekly averages of the refractivity images for all volunteers were −0.650% (week 1), −0.585% (week 2), −0.692% (week 3), and −0.628% (week 4), and the corresponding attenuation weekly averages were 1.712 dB/cm, 1.635 dB/cm, 1.673 dB/cm, and 1.653 dB/cm. There were no statistically significant changes during MC. Conclusion Although there are biological changes in breast tissue properties during the MC, we did not observe statistically significant changes in the average values of MUT refractivity and attenuation images in each breast for different weeks of the MC. This finding implies that the diagnostic accuracy of the MUT may not be affected by the timing of the scan during the MC.

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Section: Discussioncontrasting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Does the menstrual cycle affect the multimodal ultrasound tomography?

et al. 2018

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Evaluation of Multiparametric Shear Wave Elastography Indices in Malignant and Benign Breast Lesions

et al. 2022

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Breast Lesion Elastography Region of Interest Selection and Quantitative Heterogeneity: A Systematic Review and Meta-Analysis

Blank

Antaki

2017

Ultrasound in Medicine & Biology

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In this systematic review and meta-analysis, we report measured elasticities of benign and malignant breast pathologies from shear wave elastography (SWE), quantitatively confirm the effect of the selected region of interest (ROI) on these measures and test the hypothesis that a metric of heterogeneity based on the mean and maximum elasticity can improve specificity of diagnosis. The elasticities of benign, malignant and specific pathologic states are reported from 22 publications encompassing 2989 patients, identified from a structured search of the literature from May to September 2015. Twelve articles were included in a meta-analysis that grouped results by the method of ROI selection to discriminate between different pathologies. We observe a significant correlation between the method of selection of ROI for malignant mean (p < 0.001) and maximum (p = 0.027) elasticities, but no correlation with benign measures. We define a quantitative heterogeneity parameter, the "stiffness gradient," computed from the mean and maximum measured elasticities. The stiffness gradient out-performed the current standard maximum elasticity metric in stratifying malignancy risk by a margin of 15% for the partial ROI, and 42% for the maximized ROI. An anecdotal example of improved differentiation using the stiffness gradient on pathology-specific lesions is also provided. These results quantitatively indicate that the method of ROI selection in SWE not only has a significant impact on the resulting mean reported elasticity of a lesion, but may provide some insight into lesion heterogeneity. Our results suggest that further exploration of quantitative heterogeneity is warranted to improve the specificity of diagnosis.

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Changes in the elasticity of fibroadenoma during the menstrual cycle determined by real-time sonoelastography

Cited by 4 publications

References 31 publications

Does the menstrual cycle affect the multimodal ultrasound tomography?

Does the menstrual cycle affect the multimodal ultrasound tomography?

Evaluation of Multiparametric Shear Wave Elastography Indices in Malignant and Benign Breast Lesions

Breast Lesion Elastography Region of Interest Selection and Quantitative Heterogeneity: A Systematic Review and Meta-Analysis

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