Changes in the Dickkopf-1 and tartrate-resistant acid phosphatase 5b serum levels in preschool children with nephrotic syndrome

Abstract

The aim of the present study was to investigate the changes in the serum Dickkopf-1 (DKK-1) and tartrate-resistant acid phosphatase 5b (TRACP-5b) levels in preschoolers with nephrotic syndrome (NS). A total of 50 preschoolers (3-5 years old) with NS and 20 healthy preschoolers (control group) were enrolled in the prospective single-center study. The patients with NS received glucocorticoid treatment and the control group received no treatment. The levels of serum calcium, phosphorus, TRACP-5b, DKK-1 and 25-hydroxyvitamin D3 were measured at baseline and at 3 and 6 months in all the subjects. The levels of DKK-1 and TRACP-5b were significantly higher in the NS group prior to treatment when compared to the control group (P<0.05), but did not differ significantly between the two groups following treatment (P>0.05). Therefore, DKK-1 and TRACP-5b can be used as biomarkers of bone formation and bone resorption, respectively, in the early evaluation of bone metabolism.

Analysis of High Dose and Long-Term Prednisone Therapy on Trap 5B Level Change in Children with Steroid Sensitive Nephrotic Syndrome

“…We also classified the patients based on the duration of prednisone treatment and cumulative dosage of prednisone 6 months prior to the treatment. Based on the study by Zhang et al (2016) TRAP 5B serum in healthy children is not significantly different from that in patients with SN initial attack 3 and 6 months after induction. It is indicated that TRAP 5B serum level can turn back to normal level at the time of remission due to the reduction dosage of glucocorticoid and reduction of total protein leakage (Zhang et al 2016).…”

The Assessment of Bone Regulatory Pathways, Bone Turnover, and Bone Mineral Density in Vegetarian and Omnivorous Children

“…Sclerostin and Dkk-1 are powerful negative regulators of osteoblastogenesis. An increase in their levels results in reduced osteoblast differentiation and thus decreased bone formation [ 14 , 35 , 36 , 37 ]. Although the mean values of these markers were comparable in both groups of children, sclerostin concentrations were slightly lower in vegetarians.…”

Der Biomarker TRACP5b (tartratresistente saure Phosphatase 5b)

“…TRACP5b wird von Osteoklasten exprimiert und gilt als relevanter Biomarker bei metabolischen und pathologischen Erkrankungen des Knochens, aber auch bei malignen Erkrankungen mit Knochenmetastasen und der chronischen Niereninsuffizienz [3,11,18,23,25,32,36,39]. Zusätzlich wird das Enzym von aktivierten oder entzündungsfördernden Makrophagen und dendritischen Zellen exprimiert [3,7,11,18,21,23,25].…”

“…Osteosarkome), bei Haarzellleukämie (lysosomale Speicherkrankheit Morbus Gaucher), sekundärem Hyperparathyreoidismus, fortgeschrittener Niereninsuffizienz, nephrotischem Syndrom, rheumatoider Arthritis, Osteopetrose, ankylierender Spondylitis, koronarer Herzkrankheit und bei normal wachsenden Kindern auf [4,6,11,18,21,23,25,32,36,39].…”

“…B. mit Bisphosphonaten wird die Zahl der Osteoklasten und somit auch die TRACP-5b-Konzentration signifikant reduziert. Außerdem korreliert eine ansteigende Konzentration bei Mammakarzinompatientinnen unter Bisphosphonattherapie mit einem Krankheitsprogress [3,6,11,18,21,31,32,39].…”