Changes in the diagnosis of glomerular diseases in east China: a 15-year renal biopsy study

Abstract

Background: There have been some gradual changes in the distribution of renal biopsy pathological diagnoses during recent years. This study aimed to show changes in renal disease prevalence in China by investigating 10 patients diagnosed at our Kidney Disease Centre during the last 15 years.Methods and results: All patients aged 15-year-old or older who underwent renal biopsy at the First Affiliated Hospital, Zhejiang University, from 2001 to 2015 were enrolled. There were 5 common types of primary glomerulonephritis: IgA nephropathy (IgA N), membranous nephropathy (MN), mesangial progressive glomerulonephritis (MsPGN), minimal change disease (MCD), and focal segmental glomerulosclerosis (FSGS), which represented 50%, 16.8%, 15.9%, 8.1% and 2.5% of total cases, respectively. IgA nephropathy was the most common type of primary glomerulonephritis (PGN).Conclusions: Our results mostly showed a new trend that the diagnosis of IgA nephropathy was not increasing and the prevalence of membranous nephropathy had increased, becoming the second most common type of primary glomerulonephritis.Key POINTSDistinguished with other domestic studies, IgA nephropathy did not show a trend of continuous growth although it still had about the half proportion of PGN, whereas membranous nephropathy kept rising and became the second common PGN.Concerning SGN, LN peaked in the younger-age and middle-age groups with a significant female prevalence, DN, BANS and SV had a male predominance peaking in the middle-age and old-age groups.

Development and Validation of a Discrimination Model Between Primary PLA2R-Negative Membranous Nephropathy and Minimal Change Disease Confirmed by Renal Biopsy

“…Present evidences suggested that MN had the largest proportion of morbidity in elderly patients, while MCD accounts for the highest proportion of primary nephrotic syndrome in young patients [3,19,20]. Our experiments reached similar results that the age at biopsy had a certain in uence on the nomogram.…”

Chinese Herbal Injections for Primary Nephrotic Syndrome in Adults: A Systematic Review and Network Meta‐Analysis

“…In this context, the crucial TCM concept for treating PNS is to invigorate Qi, activate blood, and remove stasis, which might increase the rationality and applicability of our results. Idiopathic membranous nephropathy, which, besides IgA nephropathy, is a prevalent pathological type of PNS in China [23], has been shown to positively respond to the Qi-invigorating and stasis-removing method; moreover, the most frequently used Chinese medicines have been reported to be Astragali Radix, Angelicae Sinensis Radix, Chuanxiong Rhizoma, and Salvia Miltiorrhiza [24].…”

The spectrum of biopsy-proven renal diseases in Korea

“…Therefore, readers should keep these things in mind when they compare the results of studies. Table 1 summarizes the previous publications on frequencies of biopsy-proven renal diseases reported in China, Japan, and South Korea [1][2][3][4][5][6][7][8][9]. These data show major biopsy-proven glomerular diseases in East Asian countries.…”

“…According to the underlying etiology, MsPGN could be further classified as immunoglobulin A (IgA) nephropathy, lupus nephritis, C3 glomerulopathy, and so on. Therefore, analyses using the term MsPGN in previous studies [1,2] cannot be directly compared to other reports using refined terminologies. Secondly, indications for performing renal biopsy in patients suspected of kidney disease are quite different among countries, institutions, and even clinicians.…”