Changes in the Composition of the Rat Uterus Following a Single Injection of Relaxin

Steinetz, Bernard G.; Beach, V. L.; Blye, Richard P.; Kroc, Robert L.

doi:10.1210/endo-61-3-287

Cited by 41 publications

(19 citation statements)

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“…This conclusion is based on theoretical (Coren & Csapo, 1963) and experimental (Csapo & Takeda, 1965) evidence that the rate of development of pressure within a uterus is determined by the degree of electrical synchronization within the myometrium. The finding that rat relaxin has this property is consistent with similar findings reported for porcine relaxin (Downing, Bradshaw & Porter, 1980), and lends additional support to the contention that relaxin may mediate some of the actions of oestrogens on the uterus (Steinetz, Beach, Blye & Kroc, 1957) because oestradiol is also known to enhance the rate of rise of intrauterine pressure (Downing, Lye, Bradshaw & Porter, 1978), amongst other actions resembling those of relaxin (Steinetz et ai, 1957).…”

Section: Discussionsupporting

confidence: 76%

Demonstration of some of the physiological properties of rat relaxin

Bradshaw¹,

Downing²,

Moffatt³

et al. 1981

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Summary. Relaxin was extracted from the ovaries of pregnant rats. Material possessing uterine relaxing activity in vitro was eluted in three peaks from Sephadex G.50 columns. The 'G3 peak' material eluting in a position comparable to that of porcine relaxin inhibited myometrial activity of rats in vivo, improved the rate of rise of pressure of intrauterine pressure cycles in vivo, and, when administered to rats following progesterone and oestrogen priming, increased the distensibility of the cervix in vitro. This material also stimulated inter-pubic ligament formation in the mouse. This rat relaxin material therefore exhibits biological actions in the rat similar to those previously assigned to porcine relaxin.

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Section: Discussionsupporting

confidence: 76%

Demonstration of some of the physiological properties of rat relaxin

Bradshaw¹,

Downing²,

Moffatt³

et al. 1981

Reproduction

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“…Previous work indicated that there was a rapid water inhibition in the uterus of ovariectomized estrogentreated rats in response to relaxin (117). In addition, glycogen synthesis was also augmented by relaxin (117). Relaxin appears to possess intrinsic growth factor properties with respect to the uterus (26,83).…”

Section: The Effect Of Relaxin On the Uterusmentioning

confidence: 93%

“…Further work needs to be carried out in order to demonstrate the mechanisms by which relaxin can alter the structural composition of the uterus during pregnancy and over the postpartum period. Previous work indicated that there was a rapid water inhibition in the uterus of ovariectomized estrogentreated rats in response to relaxin (117). In addition, glycogen synthesis was also augmented by relaxin (117).…”

Section: The Effect Of Relaxin On the Uterusmentioning

confidence: 94%

Relaxin as a New Hormone*

Bryant‐Greenwood

1982

Endocrine Reviews

137

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“…Relaxin reduces uterine contractility (Krantz et al, 1950) and increases uterine growth (Steinetz et al, 1957) in rat, mouse, guinea pig, hamster, and pig (Bathgate et al, 2006c) but in humans, has little effect on uterine tone (MacLennan et al, 1986a(MacLennan et al, , 1995. In humans, relaxin is probably important for implantation rather than the later stages of pregnancy.…”

Section: Physiologic Roles Of Relaxin Family Peptide Receptors Andmentioning

confidence: 99%