Changes in the chemical composition of mineralised teeth in children after antineoplastic treatment

Krasuska-Sławińska, Ewa; Dembowska‐Bagińska, Bożenna; Brożyna, Agnieszka; Olczak‐Kowalczyk, Dorota; Czarnowska, E.; Sowińska, Agnieszka

doi:10.5114/wo.2018.74392

Cited by 5 publications

(5 citation statements)

References 16 publications

(23 reference statements)

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“…However, the presence of abnormal enamel areas has been noted in studies on children's teeth after cancer treatment (chemotherapy). In those patients, the enamel showed higher magnesium and zinc levels compared to the control group [34]. It can be concluded on this basis that the zinc content increases with the increasing magnesium content, and the enamel resistance to pathological factors is reduced.…”

Section: Discussionmentioning

confidence: 75%

Zinc Amount in Dental Enamel can be a Potential Factor of Severe Tooth Wear.

Klimuszko

Orywal

Mroczko

et al. 2021

Preprint

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Objective of the study was to assess the potential role of zinc and copper in the process of severe enamel wear. Methods: Three groups of dental enamel samples were analyzed: 50 from subjects with worn dentition, 20 from healthy volunteers in vivo and 15 healthy teeth cut longitudinally into seven layers in vitro. The amounts of Ca, Mg and Zn in the enamel bioptates were established using atomic absorption spectroscopy with an air/acetylene flame after acid biopsy technique had been applied. The concentration of Cu was established using an electrothermic method with argon gas on the AA spectrometer. Results : Mean values of calcium (Ca) and magnesium (Mg) did not differ between all the analyzed specimens. The mean value of zinc amount was very high in the samples obtained from worn teeth comparing to the healthy teeth. Statistically significant difference was confirmed between mean value of zinc amount in severe worn dentition and all the layers in vitro and in vivo. Strong positive relationships between magnesium and zinc contents have been shown at some depths. Significant difference was registered between the amount of copper in the severely worn dentitions compared to the superficial layer of the healthy teeth in vitro and in vivo. Conclusion: It was found that zinc amount was considerably different when comparing worn dentition and healthy teeth. It appears that zinc metabolism may play an important role in enamel formation and may influence the enamel resistance to wear after tooth eruption.

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Section: Discussionmentioning

confidence: 75%

Zinc Amount in Dental Enamel can be a Potential Factor of Severe Tooth Wear.

Klimuszko

Orywal

Mroczko

et al. 2021

Preprint

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“…Various analytical methods have been applied for the determination of trace elements in enamel and they are listed in Table 1. They include atomic absorption spectrophotometry (AAS) [16][17][18][19][20][21][22][23][24][25][26][27][28][29] and emission spectroscopy (AES), proton induced Xray emission (PIXE) [50][51][52][53] , inductively coupled plasma-mass spectrometry (ICP-MS) 13,14 , and laser ablation ICP-MS (LA-ICP-MS) 15,17,[31][32][33][34][35][36][37] . Another potential possibility is to use low sample consumption, micro flow nebulizer with ICP-MS, which would reduce the sample volume and may improve element spatial resolution information in successive enamel layers.…”

Section: Discussionmentioning

confidence: 99%

“…Concentration analysis of teeth has not been conducted to investigate the relationship between sample and environment only, but also for estimation of age and sex [13][14][15][16] . The investigations on the concentration of various chemical elements in teeth depending on age, the place of living, the environment, work conditions as well as diseases, pathological conditions, dietary habits and diseases causing dental caries have been carried out for a long time 8,[17][18][19][20][21][22][23][24][25][26][27][28][29][30] . Teeth can be an important deposit of exogenous substances accumulated both in the pulp and in the calcified tissues; they are an invaluable source of data from a toxicological point of view also.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity and Specificity of Various Techniques for the Trace Elemental Analysis on Teeth: A Critical Review

Singh¹,

Sehrawat²,

Sharma³

2018

BJFS

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Trace elements play an important and complex role in the human metabolism and, although present in only minute concentrations, can be either beneficial or detrimental to health. Qualitative and quantitative analyses of the trace elements from human teeth are performed using various methods. Atomic absorption spectroscopy (AAS) and Inductively coupled plasma atomic emission spectroscopy (or mass spectroscopy) (ICP-AES, MS) are the most popular methods for trace element analysis Previous studies have set the framework for developing methods aimed at elemental analysis from bones and teeth but there are areas in which the field still needs to progress. Research must be undertaken to expand the techniques to include more precision, non-destructiveness and accuracy and high detection limit, including additional human bones and teeth, non-human bones and teeth, non-skeletal materials, and to trace present and past life behaviours like migration pattern, nutrition status and occupational or environmental exposure, human provenance and reconstruction of migration pathways as well substance abuse in human skeletal remains and in living beings.

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“…Metabolic stresses/disorder ( 18 , 129 ) or hypocalcemia during enamel formation ( 130 ) may be associated with aDDE. More specifically, some pathologies identified in the scoping review may cause calcemia disorders and have a link with aDDE: chronic illness or malnutrition problems ( 131 ), vitamin D deficiency ( 16 , 132 ), phosphate deficiency ( 130 , 131 , 133 ), thyroid dysfunction ( 130 , 131 ), celiac disease (issue in calcium absorption) ( 134 ), diabetic disease ( 23 ), gestational diabetes ( 135 ), cancer ( 136 ) calcium metabolism ( 16 , 130 , 133 ), pediatric conditions ( 18 ), and antiretroviral therapy (HIV treatment) for children and adolescents because it leads to a reduced level of calcium ( 137 ).…”

Section: Methodsmentioning

confidence: 99%

Factors and Mechanisms Involved in Acquired Developmental Defects of Enamel: A Scoping Review

et al. 2022

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BackgroundDevelopmental Defects of Enamel (DDE) is a pathology of the teeth that can greatly alter the quality of life of patients (hypersensitivity, esthetic issues, loss of function, etc.). The acquired DDE may occur as a result of a wide range of acquired etiological factors and his prevalence of this pathology may reach up to 89.9%. The main objective of this research was to identify and analyze, in current literature, the factors related to acquired DDE, in order to propose a general theory about the mechanisms involved.MethodsThe search of the primary literature was conducted until [December 31, 2021]. Our search strategy uses the Pubmed/MEDLINE database and was structured around 3 terms [“Development,” “Defect,” and “Enamel”]. To be included, references had to be primary studies, written in English. Exclusion criteria were reviews, in vitro, animal, genetic or archeology studies, and studies focused on clinical management of DDE. One hundred and twenty three articles were included in this scoping review: 4 Randomized clinical trials, 1 letter, 5 cases reports, 2 fundamentals studies, and 111 observational studies (33 Cross-sectional studies, 68 Cohort study and 10 Case-control study). The quality of evidence was assessed using the PEDro scale for clinical trials, the Newcastle-Ottawa scale for observational studies, and a published tool to assess the quality of case reports and case series.ResultsA scoping review of the literature identified 114 factors potentially involved in acquired DDE. The most frequently encountered pathologies are those causing a disorder of calcium homeostasis or a perturbation of the ARNT pathway in mother or child. The link between the ARNT pathway and metabolism deficiency in uncertain and needs to be defined. Also, the implication of this mechanism in tissue impairment is still unclear and needs to be explored.ConclusionsBy identifying and grouping the risk factors cited in the literature, this taxonomy and the hypotheses related to the mechanism allow health practitioners to adopt behaviors that limit the risk of developing aDDE and to set up a prevention of dental pathology. In addition, by reviewing the current literature, this work provides guidance for basic research, clinical studies, and literature searches.

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Changes in the chemical composition of mineralised teeth in children after antineoplastic treatment

Cited by 5 publications

References 16 publications

Zinc Amount in Dental Enamel can be a Potential Factor of Severe Tooth Wear.

Zinc Amount in Dental Enamel can be a Potential Factor of Severe Tooth Wear.

Sensitivity and Specificity of Various Techniques for the Trace Elemental Analysis on Teeth: A Critical Review

Factors and Mechanisms Involved in Acquired Developmental Defects of Enamel: A Scoping Review

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