Changes in the Central Corneal Thickness in Diabetes Mellitus Patients with age and Gender Matched Healthy Controls in North Indian Population

Makkar, Bhavesh; Srivastav, Tanmay; Mishra, Deepak; Singh, Mamta

doi:10.21276/aimdr.2018.4.4.ot2

Cited by 3 publications

(5 citation statements)

References 10 publications

(19 reference statements)

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“…However, studies done by Roszkowska et al, Lee et all, Beata Urban et al and Stella Briggs supported our study with the fact that increased CCT is seen in diabetics. [17][18][19][20] This is explained by the fact that increased CCT is due to greater pleomorphism and polymegathism in their corneas as concluded by another study. But Mc Namara et al, Weston et al and Su et al suggested that the endothelial structure is altered in hyperglycemia leading to corneal hydration which increases corneal thickness.…”

Section: Discussionmentioning

confidence: 81%

“…also with the previous studies done bySiribunkum J et al 29 However, few studies such as Ozdamar Y et al and Stella Briggs et al rejected its correlation with duration of diabetes 15,20. Increased CCT in diabetics is explained by increased endothelial permeability and increased stromal swelling pressure because of accumulation of sorbitol or glycosylation of corneal collagen 13.…”

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confidence: 62%

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Central Corneal Thickness Changes in Diabetic Retinopathy. A Prospective Observational and Correlative Study

Keditso¹,

Srikanth²

2022

Int J Life Sci Pharm Res

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Generally, there is a delay of 4 to 7 years in the diagnosis of type 2 diabetes and about 20% of patients would have already developed some micro vascular complications at the time of diagnosis. To study the central corneal thickness (CCT) variation and correlate with grades of diabetic retinopathy in an adult South Indian population. The study was conducted on 184 eyes each of T2DM patients of duration more than 5 years. 98 males (53.26%) & 86 females (46.73%) were recruited. After recording age, sex and duration of diabetes, fundus examination was done. CCT measurements were determined using Ultrasonic Pachymetry. Diabetic retinopathy was classified based on ETDRS (Early diabetic retinopathy study) and mean CCT values of each group were correlated and statistically analysed using SPSS software Version 17. Out of 184 subjects recruited, 72 patients were with no diabetic retinopathy (NDR), 107 patients were with non-proliferative diabetic retinopathy (NPDR) and 5 patients were with proliferative diabetic retinopathy (PDR). The mean CCT of no diabetic retinopathy (NDR), non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) were found to be 526.14μm, 533.98μm and 555.20μm respectively. CCT was found to be thicker for diabetics with proliferative diabetic retinopathy compared to those with no retinopathy; the difference was not statistically significant (p=0.16). Uncontrolled diabetics (HbA1c >7%) had thicker corneas compared with diabetics with good control which was statistically significant (p=0.003). CCT was higher in diabetics having duration > 10 years than with duration <10 years but was not statistically significant (p=0.117).

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Section: Discussionmentioning

confidence: 81%

mentioning

confidence: 62%

Central Corneal Thickness Changes in Diabetic Retinopathy. A Prospective Observational and Correlative Study

Keditso¹,

Srikanth²

2022

Int J Life Sci Pharm Res

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“…The ocular manifestations of diabetes encompass a spectrum of conditions, including diabetic retinopathy, diabetic macular edema, extraocular muscle palsy, dry eye, diplopia, neovascular glaucoma, refractive changes, progression of cataract, and ischemic optic neuropathy [ 2 ]. Numerous studies have concluded that diabetic corneas often exhibit increased central corneal thickness (CCT) and decreased endothelial cell density (ECD), alongside evidence of polymegathism and polymorphism [ 3 ]. These changes impact ocular health and have implications for various procedures such as cataract surgery, refractive surgery, and keratoplasty, where the cornea's condition plays a crucial role [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Central Corneal Thickness and Endothelial Cell Changes in Diabetics and Age-Matched Non-diabetics in a Tertiary Care Hospital in Central India

Daigavane,

Mallareddy

2024

Cureus

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Background Diabetes has become an epidemic, significantly impacting ocular health as one of its end-organ responses. Among the various ocular complications, alterations in corneal morphology stand out. Central corneal thickness (CCT) and endothelial cell function are vital parameters in assessing intraocular pressure, conducting pre-refractive surgery evaluations, and maintaining corneal transparency. Understanding these changes in diabetic individuals compared to non-diabetics is crucial for managing ocular health in this population. Aim and objective This study evaluates and compares CCT and endothelial cell changes between diabetic individuals and age-matched non-diabetics. By analyzing these parameters, the study seeks to provide insights into the impact of diabetes on corneal morphology and its implications for ocular health. Methods The study recruited 124 patients from the Ophthalmology Outpatient Department (OPD) at Acharya Vinoba Bhave Rural Hospital (AVBRH), Sawangi. A cross-sectional research design was employed to collect data over six months. Patients were carefully selected, and informed consent was obtained from all participants. CCT and endothelial cell parameters were assessed using specular microscopy, a non-invasive imaging technique. Statistical analysis was done using the software Statistical Package for the Social Sciences (SPSS) for inferential statistics, such as t-tests and ANOVA, and comparing parameters between diabetic and non-diabetic groups. Findings were interpreted based on both statistical significance and clinical relevance. Results In diabetic patients, the mean CCT was 547.91 µm, while it was 523.62 µm in non-diabetic individuals. The T statistic for this variable was 5.14, indicating a 17 significant difference between the two groups. Similarly, significant differences were found between diabetics and non-diabetics for endothelial cell density, coefficient of variation, and hexagonality, as evidenced by their respective T statistics of 7.46, 5.17, and 4.91. Endothelial cell density averaged 2375 cells/mm 2 in diabetics and 2666.95 cells/mm 2 in non-diabetics. Additionally, the coefficient of variation was higher among people with diabetes (40.87%) compared to non-diabetics (35.09%). Hexagonality, a measure of endothelial cell shape, was lower in diabetic corneas (40.48%) than in non-diabetic corneas (46.46%). Conclusion The study observed significant differences in corneal morphology, including central thickness and endothelial cell changes, between diabetic and non-diabetic individuals. These findings underscore the impact of diabetes on ocular health and emphasize the importance of monitoring corneal parameters in diabetic patients. Understanding these changes can aid in better management and treatment strategies for ocular complications associated with diabetes.

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“…2 Ocular manifestations of diabetes include refractive changes, dry eye, extraocular muscle plasy, diplopia, diabetic macular edema, diabetic retinopathy and ischemic optic neuropathy. 3 Corneal complications caused by diabetes include delay in wound healing, loss of sensitivity of cornea, recurrent erosions and changes in tear film. 4 Diabetes mellitus affects metabolic, clinical, morphological, metabolic and physiological state of the cornea.…”

Section: Introductionmentioning

confidence: 99%

“…6 Several studies concluded that evidence of increased central corneal thickness, and decreased endothelial cell density,change in the size and shape of the endothelial cells is seen in diabetic cornea. 3 Hyperglycemia causes overexpression of inflammatory mediators and proinflammatory proteins and plays a role in the development of diabetic keratopathy. 7 Diabetic corneal neuropathy is caused due to damage to trigeminal nerve caused due to chronic hyperglycemia.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of corneal topographical and central corneal thickness changes in diabetics and non-diabetics before and after phacoemulsification: A study protocol

Mallareddy,

Daigavane

2023

F1000Res

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Diabetes is a chronic metabolic disorder and it has its effects in the eye causing various ocular complications. It is also found that diabetes causes changes in the corneal morphology. Corneal components such as epithelium, endothelium, nerves, and immune cells are affected by hyperglycemia. These changes cause a significant effect on vision in individuals with diabetes. Assessment of corneal parameters like central corneal thickness and corneal topography changes related to diabetes are essential in patients undergoing modern-day cataract surgery like phacoemulsification. Systemic condition like diabetes along with cataract surgery like phacoemulsification can influence corneal healing and fluid balance leading to changes in corneal thickness. Postoperative changes in the cornea are also important to assess the corneal health after the surgery. Comparison of preoperative and postoperative corneal measurements help in assessing the effect of phacoemulsification and health status of the cornea. Study of these changes help in preventing complications and effect on visual outcome and specialised management for individuals with diabetes undergoing cataract surgery. In diabetic patients the risk of intraoperative and postoperative complications in cataract surgery increases compared to non diabetic patients. The aim of the study is to compare corneal curvature and astigmatism by corneal topography and central corneal thickness in diabetic patients and controls before and after phacoemulsification. CTRI registration number: REF/2023/08/071341

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Changes in the Central Corneal Thickness in Diabetes Mellitus Patients with age and Gender Matched Healthy Controls in North Indian Population

Cited by 3 publications

References 10 publications

Central Corneal Thickness Changes in Diabetic Retinopathy. A Prospective Observational and Correlative Study

Central Corneal Thickness Changes in Diabetic Retinopathy. A Prospective Observational and Correlative Study

Central Corneal Thickness and Endothelial Cell Changes in Diabetics and Age-Matched Non-diabetics in a Tertiary Care Hospital in Central India

A comparative study of corneal topographical and central corneal thickness changes in diabetics and non-diabetics before and after phacoemulsification: A study protocol

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