Changes in the cellular localization of estrogen receptor alpha in the growing and regressing ovaries of Gallus domesticus during development

González-Morán, María Genoveva

doi:10.1016/j.bbrc.2014.03.122

Cited by 13 publications

(7 citation statements)

References 26 publications

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“…However, more candidate genes and single nucleotide polymorphisms (SNPs) are required for MAS in chicken breeding. Currently, accumulating evidence has confirmed that estrogen receptor 1 ( ESR1 ) and estrogen receptor 2 ( ESR2 ) genes are involved in ovarian follicular development, and ovulation in chicken and mice [13, 14, 18, 19], with a potential impact on egg production traits in laying hens.…”

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confidence: 99%

“…In quails, the marked expression of ERα mRNA in the granulosa layer of the largest follicle may be related to the role of estrogens in cell proliferation and protein synthesis in the oviduct [21]. The results of recent studies revealed that adult female mutant mice that lack ERα in the neurons during the neonatal period fail to exhibit estrous cycles or negative feedback [10], whereas the differential expression of the ESR1 gene in chicken is involved in asymmetric ovarian development [19]. In addition, a recent study demonstrated that variants in the ESR1 gene, revealed using SNP analysis, were associated with laying traits in quails [41].…”

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confidence: 99%

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Sequence variations in estrogen receptor 1 and 2 genes and their association with egg production traits in Chinese Dagu chickens

Niu

Tyasi

Qin

et al. 2017

The Journal of Veterinary Medical Science

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Estrogen receptors α (ESR1) and β (ESR2) play central roles in folliculogenesis and therefore in reproductive biology. In the present study, two single nucleotide polymorphisms (SNPs) were identified in the ESR1 and ESR2 genes using PCR-single strand conformation polymorphism (PCR-SSCP) and DNA sequencing. One of the identified SNPs, a T1101C transition located within exon 4 of the ESR1 gene, was significantly associated with hen-housed egg production (HHEP) at 30, 43, 57 and 66 weeks of age (P<0.05), and egg weight (EW) at 30 weeks (P<0.05). Another SNP, a G1755A transition leading to a non-synonymous substitution (valine 459-to-isoleucine) located within exon 8 of the ESR2 gene, was also markedly correlated with the HHEP at 30, 43, 57 and 66 weeks of age (P<0.05), and EW at 30 weeks (P<0.05). A greater proportion of the additive variance was explained by the SNPs for most of the associated egg production traits (>1%). Furthermore, the results of the combined genotype-based association analysis supported the finding that the two SNPs were associated with the traits under a study. Taken together, our findings suggest that the two sequence variations in the ESR1 and ESR2 genes may provide promising genetic markers for the early selection and prediction of advantageous phenotypes in chicken breeding.

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confidence: 99%

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confidence: 99%

Sequence variations in estrogen receptor 1 and 2 genes and their association with egg production traits in Chinese Dagu chickens

Niu

Tyasi

Qin

et al. 2017

The Journal of Veterinary Medical Science

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“…Correspondly, estrogen receptor a (ER-a), is expressed in both gonadal compartments in chicken embryos (Andrews et al, 1997, Gonzalez-Moran, 2014 Exogenous estrogens can induce cortical cell differentiation in embryonic male (ZZ) gonads (Guioli et al, 2020). While gonadal asymmetry in the chicken is driven by asymmetric expression of Pitx2 in the cortex (Rodriguez-Leon et al, 2008, Guioli and, cortical cell proliferation is related to estrogen action.…”

Section: Discussionmentioning

confidence: 99%

TGIF1is required for chicken ovarian cortical development and generation of the juxtacortical medulla

Estermann

Hirst

Major

et al. 2021

Preprint

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During early embryogenesis in amniotic vertebrates, the gonads differentiate into either ovaries or testes. The first cell lineage to differentiate gives rise to the supporting cells; Sertoli cells in males and pre-granulosa cells in females. These key cell types direct the differentiation of the other cell types in the gonad, including steroidogenic cells. The gonadal surface epithelium and the interstitial cell populations are less well studied, and little is known about their sexual differentiation programs. Here, we show the requirement of the transcription factor gene TGIF1 for ovarian development in the chicken embryo. TGIF1 is expressed in the two principal ovarian somatic cell populations, the cortex and the pre-granulosa cells of the medulla. TGIF1 expression is associated with an ovarian phenotype in sex reversal experiments. In addition, targeted over-expression and gene knockdown experiments indicate that TGIF1 is required for proper ovarian cortical formation. TGIF1 is identified as the first known regulator of juxtacortical medulla formation. These findings provide new insights into chicken ovarian differentiation and development, specifically in the process of cortical and juxtacortical medulla formation, a poorly understood area.

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“…In the literature, the effects of BPA and its estrogen‐like effects on reproductive organs and system were investigated in chicken and chicken embryos (González‐Morán, 2014, 2015; Mattsson, Olsson, & Brunström, 2011; Yu et al, 2018). In general terms, BPA appears to have negative effects on the reproductive organs and ovum development.…”

Section: Discussionmentioning

confidence: 99%

Impact of Bisphenol A on neural tube development in 48‐hr chicken embryos

Atay

Ertekin

Bozkurt

et al. 2020

Birth Defects Research

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Objectives: Bisphenol A (BPA) is one of the most heavily produced chemicals in the world. BPA is involved in the production of many substances such as cosmetics, various foodstuffs, toys, personal care products, detergents and plastic bottles all that are frequently used in daily life. Depending on BPA exposure, sexual maturation and reproductive function, and bone and brain development are adversely affected. The aim of this study is to investigate the possible effects of BPA on the development of the nervous system and neural tube in 48-hr chicken embryos. Methods: Thirty specific pathogen-free (SPF) fertilized eggs were used in the study. SPF eggs were placed in the incubator and divided into three groups at 28 hr of incubation; control, BPA 1 and BPA 2 (10 eggs in each group). At this stage of incubation, two different doses of BPA were injected subblastodermically with the Hamilton microinjector. At the end of 48 hr of incubation, all eggs were opened and embryos were dissected and separated from the embryonic membrane. All embryos were evaluated morphologically and histopathologically. Results: As the BPA dose increased, delays in the development of the nervous system and midline closure increased in the early period of chicken embryos. Depending on the dose, it was found that the embryo's crown-rump length and somite number decreased (p < .05). Conclusion: It was determined that BPA application on early chicken embryos adversely affected neural tube development. It was also found to delay midline closure.

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Changes in the cellular localization of estrogen receptor alpha in the growing and regressing ovaries of Gallus domesticus during development

Cited by 13 publications

References 26 publications

Sequence variations in estrogen receptor 1 and 2 genes and their association with egg production traits in Chinese Dagu chickens

Sequence variations in estrogen receptor 1 and 2 genes and their association with egg production traits in Chinese Dagu chickens

TGIF1is required for chicken ovarian cortical development and generation of the juxtacortical medulla

Impact of Bisphenol A on neural tube development in 48‐hr chicken embryos

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