Changes in the blood coagulation, fibrinolysis, and cytokine profile during laparoscopic and open cholecystectomy

Abstract

Only mild hypercoagulability was observed in patients who had undergone laparoscopic cholecystectomy. The cytokine surge was correlated with hypercoagulability. There was in fact a positive correlation between IL-6 level and hypercoagulability. The correlation between cytokine levels and coagulation activation may be related to the type of surgery performed. Further studies are required to investigate these issues.

The Effect of Carbon Dioxide Insufflation Applied at Different Pressures and Periods on Thrombotic Factors

“…While plasma ATIII, protein C and plasminogen values were found to be reduced in both groups; F1-F2, thrombin-antithrombin, fibrinogen, fibrin and D-Dimer values were increased in favor of open surgery. Consequently, although to a lesser extent than the open surgery, medium hypercoagulability was found to be more significant in open surgery as determined also in laparoscopic surgery [12]. Also in our study, ATIII and protein C values were decreased compared to the control group while fibrinogen value was increased.…”

“…Mild hypercoagulability was observed in patients who had undergone LC without thrombophilia. This informations may be evidence that at the subclinical level there is less intravascular clot formation with a laparoscopic than with a traditional surgical insult [12,14,21]. Protein S value was determined to be low in all groups except group D compared to the control group.…”

Saline-filled laparoscopic surgery: A basic study on partial hepatectomy in a rabbit model

“…IL-1 has been shown to induce procoagulant activity in endothelial cells, including increased release of tissue factor (TF) [44]. In a study comparing laparoscopic surgery with open surgery, the cytokine surge was correlated with hypercoagulability, and the correlation between cytokine and coagulation activation may be related to the type of surgery performed [1]. Thus, the present study seems to demonstrate the non-inferiority of SAFLS as compared to CO 2 pneumoperitoneum with respect to invasiveness.…”

“…In SAFLS, it appears that the warmed saline could prevent the occurrence of hypothermia. IL-1β and CRP levels, which were examined in the present study, were also examined in previous reports comparing laparoscopy with open laparotomy [1,41]. The cytokines IL-1, tumor necrosis factor (TNF), and interleukin-6 (IL-6) are known to be major mediators of the acute phase response [42].…”

“…In recent years, laparoscopic surgery has been performed in almost every field of surgery because it has been demonstrated to be less invasive [1]. In the past, materials such as helium, nitrous oxide, and argon have been discussed as candidates for use as insufflation agents to expand the intraluminal cavity and secure the operative field [2].…”