Changes in the before and after thyroxine treatment levels of adipose tissue, leptin, and resistin in subclinical hypothyroid patients

Akbaba, Gülhan; Berker, Dilek; Işık, Serhat; Tuna, Mazhar Müslüm; Koparal, Süha; Vural, Murat; Yılmaz, Fatma Meriç; Topçuoğlu, Canan; Güler, Serdar

doi:10.1007/s00508-015-0865-9

Cited by 15 publications

(14 citation statements)

References 52 publications

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“…TSH stimulates the production of adipokines in human abdominal adipose tissue and preadipocytes by affecting the function of the TSH receptor (TSHR) protein ( 7 ). Visceral adipose tissue (VAT) is the main adipose tissue that produces diverse adipokines, and VAT volume is increased in patients with sHT compared with VAT volume in normal controls ( 8 ). However, the morphological changes of adipocytes in sHT have not been studied.…”

Section: Introductionmentioning

confidence: 99%

Adipokine expression and endothelial function in subclinical hypothyroidism rats

Gong

Gao

Chen

et al. 2018

Endocrine Connections

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The purpose of our study was to observe adipokine expression and endothelial function in subclinical hypothyroidism (sHT) rats and to determine whether levothyroxine (LT4) treatment affects these changes. Sixty-five male Wistar rats were randomly divided into five groups: the control group; sHT A, B and C groups and the sHT + T4 group. The sHT rats were induced by methimazole (MMI) and the sHT + T4 rats were administered LT4 treatment after 8 weeks of MMI administration. Thyroid function and lipid levels were measured using radioimmunoassays and enzymatic colorimetric methods, respectively. Serum adiponectin (APN), chemerin, TNF-α, endothelin (ET-1) and nitric oxide (NO) levels were measured using ELISA kits and a nitric-reductive assay. The expression of APN, chemerin and TNF-α in visceral adipose tissue (VAT) was measured in experimental rats using RT-PCR and Western blotting. Hematoxylin–eosin (HE) staining was used to observe changes in adipose tissue. The sHT rats had significantly higher levels of thyroid-stimulating hormone (TSH), TNF-α, chemerin, ET-1, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) and lower levels of APN and NO than those in control and sHT + T4 rats. Based on Pearson correlation analysis, the levels of chemerin, TNF-α, ET-1, LDL-C, TC and triglyceride (TG) were positively correlated with TSH, but APN and NO levels were negatively correlated with TSH. These findings demonstrated that high TSH levels contribute to the changes of adipokines and endothelial dysfunction in sHT, but LT4 treatment ameliorates those changes.

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Section: Introductionmentioning

confidence: 99%

Adipokine expression and endothelial function in subclinical hypothyroidism rats

Gong

Gao

Chen

et al. 2018

Endocrine Connections

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“…Thus, 27 studies (on 1065 SCH cases and 866 subjects) were included in the final analysis 28 – 54 (Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…The number of patients varied from 10 to 67, the mean age ranged from 8.1 to 65.2 years. Smoking habit was reported by 4 studies 28 , 36 , 41 , 52 , obesity by 4 studies 28 , 32 , 40 , 52 , hypertensive by only 1 study 36 and hyperlipidaemia by 4 studies 30 , 41 , 42 , 52 .…”

Section: Resultsmentioning

confidence: 99%

Non-invasive markers of cardiovascular risk in patients with subclinical hypothyroidism: A systematic review and meta-analysis of 27 case control studies

Yao

Zhao

Zeng

et al. 2018

Sci Rep

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It has been reported that subclinical hypothyroidism (SCH) is closely related to subclinical atherosclerosis. According to the impact of SCH on noninvasive markers of cardiovascular risk, we fulfilled a meta-analysis of included studies to provide an integrated overview. We searched electronic databases and included all relevant studies involving SCH and epicardial adipose tissue (EAT), carotid intima-media thickness (CIMT), pulse wave velocity (PWV), flow-mediated dilation (FMD) and glyceryl trinitrate-induced dilation (GNT- induced dilation). The result was calculated in a meta-analysis to assess the impact of SCH on these markers. A total of 27 studies were entered in the final analysis. Compared with euthyroid subjects, SCH patients exhibited a significantly increased CIMT (SMD: 0.369 mm; 95%CI: 0.038, 0.700; P = 0.029) and EAT (SMD: 1.167 mm; 95%CI: 0.869, 1.466; P = 0.000) and increased PWV (SMD: 3.574 m/s; 95%CI: 0.935, 6.213, P = 0.008). We also found significantly lower FMD (SMD: −1.525%, 95%CI: −2.156, −0.894, P = 0.000) and lower GNT-induced dilation (SMD: −0.384%, 95%CI: −0.625, −0.142, P = 0.002). Sensitivity analysis and subgroup analysis confirmed the above results. Our meta-analysis confirmed a significant association of SCH and cardiovascular risk with arterial wall thickening and stiffening and endothelial dysfunction. These findings will help to establish detailed cardiovascular prevention strategies for SCH patients.

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“…As is known, visceral adipose tissue is the main adipose tissue producing various adipokines. Numerous evidences have shown that cytokines secreted from adipose tissue lead to endothelial dysfunction and cause atherosclerosis with dyslipidemic effects [18][19][20][21]. In a study, visceral adipose tissue volume was increased in patients with hypothyroidism [22].…”

Section: Discussionmentioning

confidence: 99%

The effects of overt hypothyroidism on adipose tissue and serum betatrophin levels

Akarsu¹,

Yoldemir²,

Altun³

et al. 2019

Journal of Surgery and Medicine

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Aim: Betatrophin, also known as angiopoietin-like peptide-8, is an adipokine in glycoprotein structure synthesized from adipose tissue and liver. Betatrophin plays a role in fat and energy metabolism by inhibiting lipoprotein lipase, the key enzyme in the hydrolysis of plasma lipoproteins. Although thyroid hormones have an active role in energy metabolism, their relationship with cholesterol and lipid metabolism is not clear. In our study, we aimed to investigate the relationship of serum betatrophin levels with energy and lipid metabolism in patients with overt hypothyroidism. Methods: This is a case-control study. The mean age of 44 patients (20 males, 24 females) with hypothyroidism was 44.7 (13.8). A total of 40 healthy volunteers, including 19 males and 21 females, were included in the study as a control group. The mean age of healthy volunteers was 44.6 (14.4) years. Fasting blood glucose, AST, ALT, urea, creatinine, TSH, free T3, free T4, HDL-cholesterol, LDLcholesterol, triglyceride (TG), total cholesterol, anti-TPO, anti-TG, insulin, HOMA-IR levels and serum betatrophin levels were measured by ELISA and compared in both groups. Results: Serum betatrophin levels were significantly higher in patients diagnosed with hypothyroidism compared to the control group (P=0.001). Serum betatrophin levels were positively correlated with TSH, TG and total cholesterol, and negatively correlated with HDL, free T3 and free T4 levels. There was no significant difference in the comparison of patients regarding anti-TPO levels in the hypothyroidism group (P=0.78). Conclusion: In our study, we found that serum betatrophin levels were high in hypothyroid patients. This study may be useful in the development of treatments targeting betatrophin in clinical practice.

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Changes in the before and after thyroxine treatment levels of adipose tissue, leptin, and resistin in subclinical hypothyroid patients

Cited by 15 publications

References 52 publications

Adipokine expression and endothelial function in subclinical hypothyroidism rats

Adipokine expression and endothelial function in subclinical hypothyroidism rats

Non-invasive markers of cardiovascular risk in patients with subclinical hypothyroidism: A systematic review and meta-analysis of 27 case control studies

The effects of overt hypothyroidism on adipose tissue and serum betatrophin levels

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