Changes in the baroreflex during pregnancy in conscious dogs: heart rate and hormonal responses.

Brooks, Virginia L.; Keil, L. C.

doi:10.1210/endo.135.5.7956910

Cited by 25 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This effect is consistent with previous work showing that NO feeds back during pregnancy to attenuate the pressor effects of angiotensin II (39,57). Angiotensin II, which is increased during pregnancy (9,11,53), stimulates NO production in vascular endothelial cells (46,47,50). Subsequently, NO counteracts the effects of angiotensin II; it limits the vasoconstrictive actions of angiotensin II by causing vasodilation (3,46).…”

Section: Receptors With and Without Nos Blockade In Nonpregnant Andsupporting

confidence: 91%

See 1 more Smart Citation

Roles of nitric oxide and angiotensin II in the impaired baroreflex gain of pregnancy

Daubert¹,

Li²,

Zucker

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

The present study tested the hypothesis that nitric oxide (NO) contributes to impaired baroreflex gain of pregnancy and that this action is enhanced by angiotensin II. To test these hypotheses, we quantified baroreflex control of heart rate in nonpregnant and pregnant conscious rabbits before and after: 1) blockade of NO synthase (NOS) with Nomega-nitro-L-arginine (20 mg/kg iv); 2) blockade of the angiotensin II AT1 receptor with L-158,809 (5 microg x kg(-1) x min(-1) iv); 3) infusion of angiotensin II (1 ng x kg(-1) x min(-1) nonpregnant, 1.6-4 ng x kg(-1) x min(-1) pregnant iv); 4) combined blockade of angiotensin II AT(1) receptors and NOS; and 5) combined infusion of angiotensin II and blockade of NOS. To determine the potential role of brain neuronal NOS (nNOS), mRNA and protein levels were measured in the paraventricular nucleus, nucleus of the solitary tract, caudal ventrolateral medulla, and rostral ventrolateral medulla in pregnant and nonpregnant rabbits. The decrease in baroreflex gain observed in pregnant rabbits (from 23.3 +/- 3.6 to 7.1 +/- 0.9 beats x min(-1) x mmHg(-1), P < 0.05) was not reversed by NOS blockade (to 8.3 +/- 2.5 beats x min(-1) x mmHg(-1)), angiotensin II blockade (to 5.0 +/- 1.1 beats x min(-1) x mmHg(-1)), or combined blockade (to 12.3 +/- 4.8 beats x min(-1) x mmHg(-1)). Angiotensin II infusion with (to 5.7 +/- 1.0 beats x min(-1) x mmHg(-1)) or without (to 8.4 +/- 2.4 beats x min(-1) x mmHg(-1)) NOS blockade also failed to improve baroreflex gain in pregnant or nonpregnant rabbits. In addition, nNOS mRNA and protein levels in cardiovascular brain regions were not different between nonpregnant and pregnant rabbits. Therefore, we conclude that NO, either alone or via an interaction with angiotensin II, is not responsible for decrease in baroreflex gain during pregnancy.

show abstract

Section: Receptors With and Without Nos Blockade In Nonpregnant Andsupporting

confidence: 91%

“…Pregnancy is also associated with elevated angiotensin II levels (9,11,53), but whether angiotensin II interacts with NO in the control of baroreflex gain during pregnancy is unknown. Therefore, a third aim of this study was to test the hypothesis that the ability of NO to decrease baroreflex gain during pregnancy is enhanced by angiotensin II.…”

mentioning

confidence: 99%

Roles of nitric oxide and angiotensin II in the impaired baroreflex gain of pregnancy

Daubert¹,

Li²,

Zucker

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…However, there is no information about these parameters throughout the complete gestation period, particularly in early and mid pregnancy. Reflex increase in heart rate (HR), plasma renin activity, concentrations of vasopressin, angiotensin-II, ACTH and cortisol have been shown to be attenuated during pregnancy (Brooks and Keil, 1994).…”

Section: Introductionmentioning

confidence: 99%

Ultrasonographic assessment of maternal cardiac function and peripheral circulation during normal gestation in dogs

Blanco

Tortora

Rodríguez

et al. 2011

The Veterinary Journal

View full text Add to dashboard Cite

“…The exact aetiology remains unknown; however, it was speculated to be related to different stresses acquired throughout life such as pregnancies and fluctuating levels of cardioprotective oestrogen (Youssef 2021). The role of oestrogen in the cardiovascular system of dogs however was unclear, while inconsistent findings on changes in the level of heart rate, cardiac output level, and echocardiographic findings during pregnancy made the exact role of hemodynamic stress on the risk of heart disease in dogs remains unclear (Brooks and Keil 1994;Olsson et al 2003;Abbott 2010;Blanco et al 2011;de Souza et al 2017;Ward et al 2020). However, in neutered dogs, although other cardiac parameters were indifferent, higher blood triglyceride (TG) and very-low-density lipoprotein (vLDL) was found compared to intact dogs, implying the lost role of oestrogen in the synthesis of antioxidant and atherosclerosis-preventing high-density lipoprotein (HDL) (Boonyapakorn et al 2020).…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Heart Disease in Pet Dogs Attended At a Veterinary Teaching Hospital in Malaysia

2022

Int J Vet Sci

View full text Add to dashboard Cite

The distribution and risk factors of canine heart disease in Malaysia are still not widely studied. This retrospective study examined the distribution of common canine heart diseases and the role of gender, age group, and breed size as risk factors of the dogs in a teaching hospital in Malaysia. Medical records of all dogs presented between 2013 and 2020 with a heart disease diagnosed were reviewed and analyzed. Univariate and multivariate logistic regression was carried out to identify the risk factors for canine heart diseases in general and based on specific disease. In a duration of 7 years, a total of 9255 dog cases were presented and 7.9% (n=734, 95% CI: 0.07-0.09) of the dogs were diagnosed with heart disease. Majority of heart disease cases were valvular disease (n=528, 95% CI: 0.05-0.06), followed by heartworm disease (n=113. 95% CI: 0.01-0.01), dilated cardiomyopathy (DCM) (n=90, 95% CI: 0.01-0.01). Senior (OR 3.54, 95% CI: 2.32-5.37) and small breed (OR 6.74, 95% CI: 4.51-10.1) dogs had higher risk for valvular disease, while large breed (OR 7.18, 95% CI: 4.00-13.01) dogs were at risk for heartworm disease. Male (OR 1.83, 95% CI:1.11-3.04) and large breed dogs (OR 3.12, 95% CI: 1.80-5.39) had greater risk for DCM, respectively. Gender, age group and breed size play important role in predicting the likelihood of heart diseases in dogs and are best to be applied in the context of specific heart diseases. Information obtained would assist clinicians with their clinical diagnosis of the heart disease.

show abstract

Changes in the baroreflex during pregnancy in conscious dogs: heart rate and hormonal responses.

Cited by 25 publications

References 28 publications

Roles of nitric oxide and angiotensin II in the impaired baroreflex gain of pregnancy

Roles of nitric oxide and angiotensin II in the impaired baroreflex gain of pregnancy

Ultrasonographic assessment of maternal cardiac function and peripheral circulation during normal gestation in dogs

Risk Factors for Heart Disease in Pet Dogs Attended At a Veterinary Teaching Hospital in Malaysia

Contact Info

Product

Resources

About