Changes in the activity of antioxidant system in patients with influenza

Abstract

N THE STUDY THE ANALYSIS OF INDICATORS OF ANTIOXIDANT DEFENSE IN INFLUENZA HAS BEEN PERFORMED. THE REGULARY INHIBITION OF CERULOPLASMIN WITH A MAXIMUM REDUCTION IN THE ERUPTIVE PHASE OF CLINICAL MANIFESTATION OF INFLUENZA AND REGULAR SIGNIFICANT INCREASE IN ERYTHROCYTE CATALASE ACTIVITY WITH A MAXIMUM VALUE AT THE HEIGHT OF THE DISEASE HAS BEEN ESTABLISHED. DURING EXTINCTION OF CLINICAL SYMPTOMS, THE GRADUAL INCREASE IN THE ACTIVITY OF CERULOPLASMIN IN THE BLOOD PLASMA WITH A SIGNIFICANT DECLINE IN CATALASE ACTIVITY OF ERYTHROCYTES TOOK PLACE. AT THE EARLY CONVALESCENCE STAGE CERULOPLASMIN ACTIVITY IN PLASMA CONTINUED TO INCREASE, AND THE LEVEL OF ERYTHROCYTE CATALASE ACTIVITY REMAINED SIGNIFICANTLY ELEVATED. NORMALIZATION OF ERYTHROCYTE CATALASE ACTIVITY IN RED BLOOD CELLS OCCURRED IN THE EARLY PERIOD OF CONVALESCENCE. CHANGES IN INDICATORS OF THE ANTIOXIDANT DEFENSE IN THE DYNAMICS OF INFLUENZA DEPENDED ON THE STAGE, SEVERITY AND CHARACTER OF COMPLICATIONS AND CONCOMITANT DISEASES.