Changes in the Acetabular Fossa of the Hip: MR Arthrographic Findings Correlated With Anatomic and Histologic Analysis Using Cadaveric Specimens

Sampatchalit, Sudsriluk; Chen, Lina; Haghighi, Parviz; Trudell, Debra; Resnick, Donald

doi:10.2214/ajr.08.1913

Cited by 12 publications

(12 citation statements)

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“…At increased grades of cartilage degeneration, T2* may be increased due to the breakdown of the collagen fibril network and the introduction of more free water in the tissue [29-31]. Alternately, shortening of T2* due to increased calcium deposits and formation of fibrocartilage may also be seen [10, 32, 33]. Accumulation of the contrast agent in articular cartilage may also be dependent on other tissue properties such as reduction in proteoglycan content [14, 15, 28].…”

Section: Discussionmentioning

confidence: 99%

T2* Relaxation Time of Acetabular and Femoral Cartilage With and Without Intraarticular Gadopentetate Dimeglumine in Patients With Femoroacetabular Impingement

Nissi

Mortazavi

Hughes

et al. 2015

American Journal of Roentgenology

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Objective To assess if the presence of intra-articular Gd-DTPA2- during clinical MR arthrography significantly alters the T2* relaxation times of hip articular cartilage in patients with femoroacetabular impingement (FAI). Materials and Methods The institutional review board (IRB) approved this study, and informed consents were obtained in this HIPAA compliant study. T2* mapping of ten patient volunteers (F/M: 7/3, age range 14-49, mean±SD = 33.0 ± 12.2 years) with symptomatic FAI was performed before and after intra-articular Gd-DTPA2- administration. Overall 323 regions of interest (ROIs) were defined in acetabular and femoral cartilage each, pre- and post-Gd injection. Agreement of the relaxation times between pre- and post-Gd was assessed using Krippendorff's alpha coefficient and linear regression through the origin. Results Pre-Gd and post-Gd T2* relaxation times in both acetabular and femoral cartilage were found to agree strongly. Specifically, estimated Krippendorff's alphas were greater than 0.8 for both acetabular and femoral cartilage, and linear regressions through the origin yielded estimated slopes very close to 1 and R2 values greater than 0.98. Conclusions These results indicate that intra-articular injection of Gd-DTPA2-, along the protocol described in this study, has little effect on T2* values of femoral and acetabular cartilage. The results suggest that T2* mapping can be safely performed as an addition to standard clinical hip imaging protocol utilizing Gd-DTPA2-.

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Section: Discussionmentioning

confidence: 99%

T2* Relaxation Time of Acetabular and Femoral Cartilage With and Without Intraarticular Gadopentetate Dimeglumine in Patients With Femoroacetabular Impingement

Nissi

Mortazavi

Hughes

et al. 2015

American Journal of Roentgenology

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“…MR arthrography and histologic correlations in cadaveric specimens have revealed fibrocartilage transformation with superimposed deposition of calcium hydroxyapatite (53). Furthermore, fibrocartilagenous metaplasia undergoes mineralization by osteoblasts with penetration of capillaries at the osteochondral junction and subsequent deposition of osteoid matrix (54).…”

Section: Discussionmentioning

confidence: 99%

Acetabular Cartilage Assessment in Patients with Femoroacetabular Impingement by Using T2* Mapping with Arthroscopic Verification

Ellermann¹,

Ziegler²,

Nissi³

et al. 2014

Radiology

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“…[135][136][137] Hair follicle regeneration and dermal healing is disrupted when adipocyte differentiation is inhibited, [138] and the addition of adipocyte precursors can activate new hair growth. [138] Adipose tissue in the acetabular fossa of the hip and deep to the patellar tendon of the knee [139,140] serves biomechanical roles by dissipating stress and reducing friction [141] and may also play a role in adipokine and paracrine signaling during osteoarthritis and joint inflammation. [142,143] In mammary tissue, WAT and the mammary gland epithelium both remodel during pregnancy, lactation, and ovulation.…”

Section: Adipose Tissue Structure-function Relationshipsmentioning

confidence: 99%

Biomaterials to Mimic and Heal Connective Tissues

2019

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Connective tissue is one of the four major types of animal tissue and plays essential roles throughout the human body. Genetic factors, aging, and trauma all contribute to connective tissue dysfunction and motivate the need for strategies to promote healing and regeneration. The goal of this Review is to link a fundamental understanding of connective tissues and their multiscale properties to better inform the design and translation of novel biomaterials to promote their regeneration. We discuss major clinical problems in adipose tissue, cartilage, dermis, and tendon that inspire the need to replace native connective tissue with biomaterials. We then detail multiscale structure-function relationships in native soft connective tissues that may be used to guide material design. Several biomaterials strategies to improve healing of these tissues that incorporate biologics and are biologic-free are reviewed. Finally, we highlight important guidance documents and standards (ASTM, FDA, EMA) that are important to consider for translating new biomaterials into clinical practice.

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Changes in the Acetabular Fossa of the Hip: MR Arthrographic Findings Correlated With Anatomic and Histologic Analysis Using Cadaveric Specimens

Cited by 12 publications

References 11 publications

T2* Relaxation Time of Acetabular and Femoral Cartilage With and Without Intraarticular Gadopentetate Dimeglumine in Patients With Femoroacetabular Impingement

T2* Relaxation Time of Acetabular and Femoral Cartilage With and Without Intraarticular Gadopentetate Dimeglumine in Patients With Femoroacetabular Impingement

Acetabular Cartilage Assessment in Patients with Femoroacetabular Impingement by Using T2* Mapping with Arthroscopic Verification

Biomaterials to Mimic and Heal Connective Tissues

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