Changes in Testis, Epididymis and Other Accessory Organs of Male Rats Treated with Anandron During Sexual Maturation

Dhar, J.D.; Setty, B.S.

doi:10.1080/07435809009033002

Cited by 8 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The functioning of the gonadal organ during the growing period is in direct proportion to the weight of the organ ( 13 ). Therefore, in this study, the weights of the gonadal organs were compared by absolute value, not by the value per 100 g body weight.…”

Section: Resultsmentioning

confidence: 99%

The Interactive Effect of Dietary Fat-Soluble Vitamin Levels on the Depression of Gonadal Development in Growing Male Rats Kept under Disturbed Daily Rhythm

Hanai

Esashi²

2011

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

SummaryThe purpose of this study was to clarify the effects of nutrients on the gonadal development of male rats kept under constant darkness as a model of disturbed daily rhythm. In the present study we examined fat-soluble vitamins and their interactions in this test population. Four fat-soluble vitamins (vitamin A (V.A), vitamin D (V.D), vitamin E (V.E) and vitamin K (V.K)) were selected as experimental factors, and the dietary content of these vitamins was normal (AIN-93G) or three times the normal content. Lighting conditions (constant darkness or normal lighting) were also added as a factor. Four-week-old rats (Fischer 344 strain) were kept under constant darkness or normal lighting (12-h light/dark cycle) for 4 wk. The lighting condition and V.E, and the interactions between the lighting condition and V.E and between V.A and V.D were observed to affect the testes and epididymides weights. There was an influence of the lighting condition only on the seminal vesicles and prostate weights and the serum testosterone concentration. Among the constant darkness groups (D-groups), the highest value for testes weight was observed under the normal-V.A, normal-V.D and high-V.E diet. The interaction between lighting condition and V.E showed the testes weight increased slightly in response to changing to a high-V.E diet from a normal-V.E diet under normal lighting (N-group) but was greatly increased in response to this change in the D-group. It became clear that the amount of dietary V.E necessary for the gonadal development of rats increases when rats are kept under constant darkness. Key Words constant darkness, disturbed daily rhythm, gonad, fat soluble vitamin, orthogonal arrayThe number of people who are living under disturbed daily rhythm has been increasing due to the globalization of business and social activities, and diversification of the forms of labor. Such irregularities in daily rhythm adversely affect bio-regulatory mechanisms, resulting in an abnormal diurnal rhythm that can impede biological activities structurally and functionally. The process by which such disorders are induced is, in theory, dependent upon the nutritional condition of the individual. However, there are no basic data on the nutritional aspects of maintaining or promoting health under the condition of disturbed daily rhythm. Metabolic function changes under a condition of disturbed daily rhythm such as constant darkness, and it can be presumed that nutritional requirements in such an environment change, as well. The perspective behind this research is as follows: as basic data on the relationship between nutritional status and gonadal development in rats with disturbed daily rhythm accumulate, these data can be used for human research, and finally, dietary reference intakes can be compiled for persons living under disturbed daily rhythm.Lighting is one of the key external factors for the formation of daily rhythm. Rats kept under constant darkness develop disturbances in their feeding and motoractivity rhythms, and suffer from alter...

show abstract

Section: Resultsmentioning

confidence: 99%

The Interactive Effect of Dietary Fat-Soluble Vitamin Levels on the Depression of Gonadal Development in Growing Male Rats Kept under Disturbed Daily Rhythm

Hanai

Esashi²

2011

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

show abstract

“…The functioning of the gonadal organ in the growing period is in direct proportion to the weight of the organ ( 14 ). Therefore, in this study, the weights of the gonadal organs were compared by absolute value, not by the value per 100 g body weight; and the high weight of the gonadal organ was evaluated as being suitable.…”

Section: Resultsmentioning

confidence: 99%

The Effects of Calcium, Phosphorus, Magnesium, Sodium, and Zinc in Improving the Depression of Gonadal Development in Growing Male Rats Kept under a Disturbed Daily Rhythm-Investigations Based on the L16(215)-Type Orthogonal Array

Hanai¹,

Esashi²

2006

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

SummaryThe purpose of this study was to clarify the effects of nutrients on the gonadal development of male rats kept under constant darkness as a model of disturbed daily rhythm. This experimental protocol was designed based on the L 16 ( 2 15 )-type orthogonal array, which can examine six factors. Five minerals (calcium (Ca), phosphorus (P), magnesium (Mg), sodium (Na), and zinc (Zn)) were selected as experimental factors, and the dietary content of these minerals was normal (AIN-76 diet) or 1/3.5 of the normal content. Lighting conditions (constant darkness or normal lighting) were also added as a factor. Four-week-old rats (Fischer 344 strain) were kept under constant darkness or normal lighting (12-h light/dark cycle) for 4 wk. After 4 wk, the gonadal weights and serum testosterone content were evaluated. The lighting condition, Ca, Mg, and Na, and the interactions between the lighting condition and Ca, and Mg and Na were observed to affect the testes weight. Among the constant darkness groups (D-groups), the highest value for testes weight was observed under the normal-Ca, normal-Mg, and normal-Na diet, and the lowest value was observed under the low-Ca, normal-Mg, and low-Na diet. Among the normal lighting groups (N-groups), the highest value for testes weight was observed under the low-Ca, normal-Mg, and normal-Na diet, and the lowest value was observed under the normal-Ca, normal-Mg, and low-Na diet. Among the D-groups, the highest value for serum testosterone was observed under the normal-Ca, normal-Mg, and low-Na diet. Among the N-groups, the highest value was observed under the low-Ca, normal-Mg, and low-Na diet. It became clear that the amount of dietary Ca necessary for the gonadal development of rats increases when rats are kept under constant darkness as a model of disturbed daily rhythm compared with the normal lighting condition.

show abstract

“…The functioning of the gonadal organ in the growing period is in direct proportion to the weight of organ (16). Therefore, in this study, the weights of the gonadal organs were compared by absolute value, not by the value per 100g body weight.…”

Section: Resultsmentioning

confidence: 99%

The Effects of Nutrients in Improving the Depression of Gonadal Development in Growing Male Rats Kept under Disturbed Daily Rhythm -Investigations Based on the L8(27) Type Orthogonal Array-

Hanai

Kubo

Esashi

2003

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

SummaryThe purpose of this experiment was to clarify the effects of nutrients on the gonadal development of male rats kept under constant darkness as a model of disturbed daily rhythm. Protein, methionine, vitamins, minerals and fat were selected as experimental factors, and eight kinds of diets were prepared based on the L8(27) type orthogonal array. Dietary contents of the nutrients were normal (AIN-76 diet) or 1/3 to 1/2 of the normal content. Four-week-old rats (Fischer 344 strain) were kept under constant darkness for 4 wk. Control groups were kept under 12-h light/dark cycle. After 4 wk, the gonadal weights and serum testosterone content were evaluated. The effects of nutrients on gonadal develop ment in rats differed between constant darkness groups (D-groups) and normal lighting groups (N-groups). Among the D-groups, the highest value for testes weight was observed under the normal protein, methionine added, low vitamin, low mineral and normal fat diet. The lowest value for testes weight was observed under the low protein, methionine added, normal vitamin, normal mineral and low fat diet. Among the N-groups, the highest value for testes weight was observed under the normal protein and no methionine diet, and the lowest value was observed under the low protein and no methionine diet. Among the D groups, the highest value for serum testosterone was observed under the normal protein and low mineral diet. In the N-groups, serum testosterone was not affected by nutritional factors. It became clear that the amounts of protein, methionine, vitamins, minerals, and oil which are necessary for the gonadal development of growing male rats change when kept in constant darkness.

show abstract

Changes in Testis, Epididymis and Other Accessory Organs of Male Rats Treated with Anandron During Sexual Maturation

Cited by 8 publications

References 13 publications

The Interactive Effect of Dietary Fat-Soluble Vitamin Levels on the Depression of Gonadal Development in Growing Male Rats Kept under Disturbed Daily Rhythm

The Interactive Effect of Dietary Fat-Soluble Vitamin Levels on the Depression of Gonadal Development in Growing Male Rats Kept under Disturbed Daily Rhythm

The Effects of Calcium, Phosphorus, Magnesium, Sodium, and Zinc in Improving the Depression of Gonadal Development in Growing Male Rats Kept under a Disturbed Daily Rhythm-Investigations Based on the L16(215)-Type Orthogonal Array

The Effects of Nutrients in Improving the Depression of Gonadal Development in Growing Male Rats Kept under Disturbed Daily Rhythm -Investigations Based on the L8(27) Type Orthogonal Array-

Contact Info

Product

Resources

About